Brown Recluse Spider Bite Resulting in Coombs Negative Hemolytic Anemia in a Young Male Requiring Blood Transfusion

Rare Loxoscelism-Associated IgG Coombs-Positive Hemolytic Anemia Treated Successfully With Systemic Corticosteroids

“…These conditions can include various infections (such as hepatitis C, HIV, Epstein-Barr virus, and babesiosis), lymphoproliferative disorders (like chronic lymphocytic leukemia and multiple myeloma), autoimmune disorders (such as systemic lupus erythematosus, rheumatoid arthritis), and immunodeficiencies (like hematopoietic stem cell transplantation, inherited disorders, solid organ transplant, hypogammaglobulinemia), while the remainder is classified as idiopathic [9][10][11]. Although rare, there have been reports of both Coombs-positive and Coombs-negative hemolytic anemia in patients due to insect bites, including spider bites [12,13]. In a study by Nguyen N et al it was observed that out of nine patients who developed moderate to severe loxoscelism, all of them exhibited hemolytic anemia [14].…”

Natural toxins and One Health: a review

“…Clinicians in Michigan, USA observed pruritus, redness, swelling, severe pain, fever, nausea and diarrhea in a fifty-nine year old woman who was bitten by a brown recluse spider, pointing to morbidities that could be caused by spider venom [ 133 ]. A nineteen-year old man bitten by brown recluse spider presented with fever, nausea, pain and dehydration to the extent that required intravenous fluid administration [ 134 ]. A retrospective study carried out on 59 patients showed elevated white blood cell count and impaired hepatic and renal function in addition to severe pain, inflammation and redness at the site bitten by black widow spiders [ 135 ].…”