Brown tumors developing in renal transplant recipients with persistent hyperparathyroidism: 2 case reports and review of literature

Lee, S; Lerer, Daniel; Dorfman, Howard D.; Coco, Maria

doi:10.5414/cnp61289

Cited by 8 publications

(5 citation statements)

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“…Brown tumors, a late manifestation of secondary hyperparathyroidism, are due to bone microfractures with subsequent bleeding causing localized osteoclast influx, osteolysis, and subsequent reactional medullar fibrosis and leading to the constitution of tumoral brown masses because of haemosiderin deposits [9]. In our patient, total body bone scintigraphy did not show increased uptake by the mandibular OF, an argument against a brown tumor.…”

Section: Discussionmentioning

confidence: 53%

A Swelling in the Mouth in a Chronic Hemodialysis Patient

Devresse

Raptis

Claes

et al. 2016

Case Reports in Nephrology

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Oral manifestations of severe secondary hyperparathyroidism include maxillary and mandibular deformities, brown tumors, dental abnormalities, and metastatic calcification of soft tissues. We report on a chronic hemodialysis (HD) woman with severe, uncontrolled secondary hyperparathyroidism and a painful, nontender mass in the floor of her mouth. The most likely clinical diagnosis was a bone tumoral lesion of the oral cavity, secondary to renal osteodystrophy. Unexpectedly, pathological examination showed characteristic features of ossifying fibroma (OF) of the jaw, a rare, benign fibroosseous lesion characterized by the replacement of normal bone by collagen and fibroblasts containing varying amounts of mineralized substance. The occurrence of an OF in chronic HD patients is exceptional. Differential diagnosis must be made with bone tumoral lesions secondary to renal osteodystrophy. Surgical removal is the treatment of choice. The pathogenesis of OF in the setting of secondary hyperparathyroidism remains unknown. Parathyroidectomy may not be necessary to avoid OF recurrence after surgical removal.

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Section: Discussionmentioning

confidence: 53%

A Swelling in the Mouth in a Chronic Hemodialysis Patient

Devresse

Raptis

Claes

et al. 2016

Case Reports in Nephrology

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“…Medical intervention of normalizing blood calcium and phosphate levels should stop the progression of a BT. If unsuccessful, a total or subtotal parathyroidectomy is recommended [7]. Our patient was initially managed pharmacologically with cinacalcet, but responded insufficiently.…”

Section: Discussionmentioning

confidence: 92%

A Rare Presentation of a Brown Tumor on the Spinal Column Secondary to Chronic Renal Failure Managed by Dialysis

et al. 2020

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A brown tumor (BT) is a rare tumor composed of giant cells, and is a complication seen in secondary hyperparathyroidism related to chronic renal failure. Mediated by osteoclastic bone resorption, increasing bone turnover leads to the formation of a multinucleated giant cell tumor, also known as osteitis fibrosa cystica or BT. A BT is usually located at, but not limited to, the mandible, long bones, pelvis, and ribs. We present a case of a 40-year-old female with a BT and a history of chronic renal failure managed by dialysis. A concurrent parathyroid adenoma was also found on imaging. A laminectomy of T8 and partial T7 -T9 fusion was completed, followed by a complete parathyroidectomy 10 days later.

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“…Therefore, hypersecretion of PTH can be inhibited by eliminating phosphate excess. It can be achieved by oral antacids, dietetic restrictions and peritoneal dialysis or haemodialysis [4,10,11,12]. However, after a certain period of time, the enlarged parathyroid gland might not react to the fluctuant serum calcium level, therefore some degree of autonomous glandular function develops [5,13].…”

Section: Discussionmentioning

confidence: 99%

Vertebral Brown Tumor in Childhood (Case Report)

Szeverényi¹,

Dezső²,

Deményi³

et al. 2011

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One form of renal osteodystrophy secondary to chronic renal failure is the osteitis fibrosa cystica, which is the complication of secondary hyperparathyroidism. Osteitis fibrosa cystica is a histologically benign, tumor-like lesion of bones. Since early diagnosis and treatment of hyperparathyroidism is available nowadays, the development of osteitis fibrosa cystica has become rare. It can only be found in neglected cases and in those where the treatment of chronic renal failure is unsuccessful. We present the case of a boy, who developed osteitis fibrosa cystica as a complication of secondary hyperparathyroidism. Our article is the first to report a case about an osteitis fibrosa cystica found in a child’s vertebra and this tumor was the only one, which reached a size of approximately 10 × 15 × 15 cm. We present the CT films and X-ray pictures, the surgical solution and the results of the histological examination

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Brown tumors developing in renal transplant recipients with persistent hyperparathyroidism: 2 case reports and review of literature

Cited by 8 publications

References 0 publications

A Swelling in the Mouth in a Chronic Hemodialysis Patient

A Swelling in the Mouth in a Chronic Hemodialysis Patient

A Rare Presentation of a Brown Tumor on the Spinal Column Secondary to Chronic Renal Failure Managed by Dialysis

Vertebral Brown Tumor in Childhood (Case Report)

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