Brownian diffusion of gold nanoparticles in an optical trap studied by fluorescence correlation spectroscopy

Wang, J.; Li, Z.; Yao, Cuiping; Xue, Fei; Zhang, Z. X.; Hüttmann, Gereon

doi:10.1134/s1054660x1101021x

Cited by 10 publications

(9 citation statements)

References 31 publications

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“…The highest pulse energy fluence we use in this work is 14.1 J/m 2 , virtually ensuring that water vapor bubbles are not forming around the AuNPs in our system. Additionally, Wang et al found that, when 50 nm AuNPs are irradiated with pulse energy fluences below ∼41 J/m 2 using a pulse width of 75 fs and repetition rate of 80 MHz, the Brownian motion of the AuNPs is stronger than the trapping potential, allowing us to conclude that optical forces do not play a significant role in our system. Figure B,C displays a transmission electron microscopy (TEM) image and the corresponding extinction spectra of the 55 nm AuNPs used in this work.…”

Section: Resultsmentioning

confidence: 85%

Femtosecond Laser Pulse Excitation of DNA-Labeled Gold Nanoparticles: Establishing a Quantitative Local Nanothermometer for Biological Applications

Hastman

Melinger²,

Lasarte‐Aragonés³

et al. 2020

ACS Nano

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Femtosecond (fs) laser pulsed excitation of plasmonic nanoparticle (NP)−biomolecule conjugates is a promising method to locally heat biological materials. Studies have demonstrated that fs pulses of light can modulate the activity of DNA or proteins when attached to plasmonic NPs; however, the precision over subsequent biological function remains largely undetermined. Specifically, the temperature the localized biomolecules "experience" remains unknown. We used 55 nm gold nanoparticles (AuNPs) displaying double-stranded (ds) DNA to examine how, for dsDNA with different melting temperatures, the laser pulse energy fluence and bulk solution temperature affect the rate of local DNA denaturation. A universal "template" single-stranded DNA was attached to the AuNP surface, and three dye-labeled probe strands, distinct in length and melting temperature, were hybridized to it creating three individual dsDNA-AuNP bioconjugates. The dye-labeled probe strands were used to quantify the rate and amount of DNA release after a given number of light pulses, which was then correlated to the dsDNA denaturation temperature, resulting in a quantitative nanothermometer. The localized DNA denaturation rate could be modulated by more than threefold over the biologically relevant range of 8−53 °C by varying pulse energy fluence, DNA melting temperature, and surrounding bath temperature. With a modified dissociation equation tailored for this system, a "sensed" temperature parameter was extracted and compared to simulated AuNP temperature profiles. Determining actual biological responses in such systems can allow researchers to design precision nanoscale photothermal heating sources.

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Section: Resultsmentioning

confidence: 85%

Femtosecond Laser Pulse Excitation of DNA-Labeled Gold Nanoparticles: Establishing a Quantitative Local Nanothermometer for Biological Applications

Hastman

Melinger²,

Lasarte‐Aragonés³

et al. 2020

ACS Nano

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“…However, the values of trapping stiffness obtained with nanoholes (k ¼ 0.2 pN/nm W) 64 are lower than the performance of plasmonic nanoantennas, due to the absence of a resonant behavior, which makes more difficult the attraction of the target object close to the trapping site. Higher values of input power of several milliwatts should be applied to enhance the trapping stiffness, because k increases linearly with the power of the laser, but at the expense of thermal effects that would affect the Brownian motion of the nanoparticles around the nanohole.…”

Section: Plasmonic Resonatorsmentioning

confidence: 90%

“…The Langevin equation takes the effect of Brownian motion into account for a rigorous description of forces affecting the velocity and trajectory of the particle’s motion. The Brownian motion is a diffusion process that is governed by the Stokes–Einstein’s diffusion coefficient D , given by 64 …”

Section: Main Parameters Of Optical Trappingmentioning

confidence: 99%

Photonic and Plasmonic Nanotweezing of Nano- and Microscale Particles

et al. 2017

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The ability to manipulate and sense biological molecules is important in many life science domains, such as single-molecule biophysics, the development of new drugs and cancer detection. Although the manipulation of biological matter at the nanoscale continues to be a challenge, several types of nanotweezers based on different technologies have recently been demonstrated to address this challenge. In particular, photonic and plasmonic nanotweezers are attracting a strong research effort especially because they are efficient and stable, they offer fast response time, and avoid any direct physical contact with the target object to be trapped, thus preventing its disruption or damage. In this paper, we critically review photonic and plasmonic resonant technologies for biomolecule trapping, manipulation, and sensing at the nanoscale, with a special emphasis on hybrid photonic/plasmonic nanodevices allowing a very strong light-matter interaction. The state-of-the-art of competing technologies, e.g., electronic, magnetic, acoustic and carbon nanotube-based nanotweezers, and a description of their applications are also included.

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“…Optical tweezers (OTs) have been successfully used for the study of the random motion of single colloidal microparticles and NPs. − OTs have made it possible to determine the instantaneous velocity of microparticles at room temperature that, at short time scales, is described by the equipartition theorem . Furthermore, the transition from ballistic to diffusive Brownian motion of an individual NP at thermal equilibrium has been also successfully observed using OTs .…”

mentioning

confidence: 99%

Exploring Single-Nanoparticle Dynamics at High Temperature by Optical Tweezers

Labrador‐Páez

Ortiz‐Rivero

et al. 2020

Nano Lett.

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The experimental determination of the velocity of a colloidal nanoparticle (v NP ) has recently became a hot topic. The thermal dependence of v NP is still left to be explored although it is a valuable source of information allowing, for instance, the discernment between ballistic and diffusive regimes. Optical tweezers (OTs) constitute a tool especially useful for the experimental determination of v NP although they have only been capable of determining it at room temperature. In this work, we demonstrate that it is possible to determine the temperature dependence of the diffusive velocity of a single colloidal nanoparticle by analyzing the temperature dependence of optical forces. The comparison between experimental results and theoretical predictions allowed us to discover the impact that the anomalous temperature dependence of water properties has on the dynamics of colloidal nanoparticles in this temperature range.

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Brownian diffusion of gold nanoparticles in an optical trap studied by fluorescence correlation spectroscopy

Cited by 10 publications

References 31 publications

Femtosecond Laser Pulse Excitation of DNA-Labeled Gold Nanoparticles: Establishing a Quantitative Local Nanothermometer for Biological Applications

Femtosecond Laser Pulse Excitation of DNA-Labeled Gold Nanoparticles: Establishing a Quantitative Local Nanothermometer for Biological Applications

Photonic and Plasmonic Nanotweezing of Nano- and Microscale Particles

Exploring Single-Nanoparticle Dynamics at High Temperature by Optical Tweezers

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