Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways

Cheng, Ziying; Xing, Yuan; Qu, Yi; Li, Xia; Wu, Guozhen; Li, Chenwei; Zu, Xianpeng; Yang, Niao; Ke, Xisong; Zhou, Juan; Xie, Ning; Xu, Xiuru; Liu, Shanrong; Shen, Yun-Heng; Li, Hui‐Liang; Zhang, Guoqing

doi:10.1016/j.canlet.2017.06.014

Cited by 38 publications

(42 citation statements)

References 34 publications

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“…In addition, p38-MAPK pathway activation and NF-kappaB inhibition were crucial for BD-mediated pancreatic cell death 9 . Furthermore, BD suppressed hepatocellular carcinoma growth in vivo and in vitro by diminishing Wnt translation activity 10 . Although the antitumor activity of BD has been reported in many studies, the exact mechanisms have not yet been demonstrated, particularly the mechanisms involved in BD-induced lung cancer cell proliferation inhibition.…”

Section: Introductionmentioning

confidence: 99%

Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo

et al. 2020

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Worldwide, lung cancer remains a leading cause of cancer mortality. Bruceine D (BD) has been shown to induce pancreatic cancer cell death via several different mechanisms. In this study, we demonstrated that BD inhibited lung cancer cell proliferation. Apoptosis and autophagy were the most important mechanisms involved in BD-induced lung cancer cell death, and complete autophagic flux was observed in A549 and NCI-H292 cells. In addition, BD significantly improved intracellular reactive oxygen species (ROS) levels. BD-mediated cell apoptosis and autophagy were almost inhibited in cells pretreated with N-acetylcysteine (NAC), an ROS scavenger. Furthermore, MAPK signaling pathway activation contributed to BD-induced cell proliferation inhibition and NAC could eliminate p-ERK and p-JNK upregulation. Finally, an in vivo study indicated that BD inhibited the growth of lung cancer xenografts. Overall, BD is a promising candidate for the treatment of lung cancer owing to its multiple mechanisms and low toxicity.

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Section: Introductionmentioning

confidence: 99%

Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo

et al. 2020

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“…Several studies have shown that BD exhibits numerous pharmacological traits including anti‐inflammatory, anti‐parasitic, and hypoglycemic activities . Furthermore, BD exhibits significant anti‐tumor activity in pancreatic cancer, human chronic myeloid leukemia, and hepatocellular carcinoma . However, the underlying mechanism of action of BD on osteosarcoma remains unclear.…”

Section: Introductionmentioning

confidence: 99%

“…17 Furthermore, BD exhibits significant anti-tumor activity in pancreatic cancer, 18 human chronic myeloid leukemia, 19 and hepatocellular carcinoma. 20 However, the underlying mechanism of action of BD on osteosarcoma remains unclear. Therefore, this study was designed to explore the role of BD on osteosarcoma in vitro and in vivo, to evaluate the underlying mechanism, and demonstrate its potential as a therapeutic candidate for osteosarcoma treatment.…”

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confidence: 99%

Bruceine D inhibits tumor growth and stem cell‐like traits of osteosarcoma through inhibition of STAT3 signaling pathway

Wang

Zhong

et al. 2019

Cancer Medicine

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Patients with osteosarcoma exhibiting resistance to chemotherapy or presenting with metastasis usually have a poor prognosis. Osteosarcoma stem cells (OSCs) are a potential cause of tumor metastasis, relapse, and chemotherapy resistance. Therefore, it is necessary to develop novel therapeutic drugs, which not only kill osteosarcoma cells but also target OSCs. This study aims to explore the anti‐osteosarcoma effects of Bruceine D (BD), a natural compound derived from Brucea javanica, and investigate its underlying mechanisms. Results demonstrated that BD could significantly inhibit cell proliferation and migration, induce cell cycle arrest, and promote apoptosis in osteosarcoma cells. Besides, BD could also suppress the sphere‐forming and self‐renewal ability of OSCs. Mechanistically, the inhibitory role of BD on osteosarcoma cell growth and migration including OSC stemness was partially executed through the inhibition of STAT3 signaling pathway. More importantly, BD showed significant anti‐osteosarcoma activity without obvious side effects in vivo. Collectively, the results of this study demonstrated that BD exerts a strong inhibitory effect on tumor growth and stem cell like traits of osteosarcoma which may be partially due to STAT3 inhibition, suggesting that BD maybe a promising therapeutic candidate against osteosarcoma.

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“…It is known that dysregulation of cell cycle leading to uncontrolled cell proliferation and apoptosis evasion are hallmarks of all cancer cell types [29,[38][39][40][41]. Indeed, through various cell proliferation assays like Sulforhodamine B assay, MTT assay, and Cell Counting Kit 8 assay, BD has been established to exhibit anti-proliferative properties against pancreatic cancer cells (PANC-1, SW1990, CAPAN-1) [29,37], lung cancer cells [A549, NCI-H292, non-small cell lung cancer (NSCLC) H460] [28,42,43], chronic myeloid leukemia (K562) [44], breast cancer cells (MDA-MB-231) [30], hepatocellular carcinoma cells (Bel7404, HepG2, Hep3B, Huh7, PLC) [45,46], and osteosarcoma cells (MNNG/HOS, U-2OS, MG-63, Saos-2) [47]. In all of the investigated cancer cell lines, there was increased activation of pro-apoptotic proteins like B-cell lymphoma 2 (Bcl-2) associated protein (Bax) and Bak and downregulation of anti-apoptotic proteins like Bcl-2 and myeloid cell leukemia 1 (Mcl-1) [48], all of which are tightly linked to cellular proliferation and apoptotic pathways like phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of Rapamycin (mTOR), c-Jun N-terminal kinase (JNK), mitogen-activated protein kinases (MAPK), and canonical Wnt signaling pathways ( Figure 1) [49][50][51][52].…”

Section: Anti-proliferative and Pro-apoptotic Effects Of Bdmentioning

confidence: 99%

A brief overview of antitumoral actions of bruceine D

Sin

Bhardwaj

Pandey

et al. 2020

Exploration of Targeted Anti-Tumor Therapy

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Cancer remains the second leading cause of mortality globally. In combating cancer, conventional chemotherapy and/or radiotherapy are administered as first-line therapy. However, these are usually accompanied with adverse side effects that decrease the quality of patient’s lives. As such, natural bioactive compounds have gained an attraction in the scientific and medical community as evidence of their anticancer properties and attenuation of side effects mounted. In particular, quassinoids have been found to exhibit a plethora of inhibitory activities such as anti-proliferative effects on tumor development and metastasis. Recently, bruceine D, a quassinoid isolated from the shrub Brucea javanica (L.) Merr. (Simaroubaceae), has come under immense investigation on its antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. In this review, we have highlighted the antineoplastic effects of bruceine D and its mode of actions in different tumor models.

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Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways

Cited by 38 publications

References 34 publications

Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo

Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo

Bruceine D inhibits tumor growth and stem cell‐like traits of osteosarcoma through inhibition of STAT3 signaling pathway

A brief overview of antitumoral actions of bruceine D

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