Brucellosis and the Respiratory System

Pappas, Georgios; Bosilkovski, Mile; Akritidis, Nikolaos; Mastora, Maria; L, Krteva; Tsianos, E.V.

doi:10.1086/378125

Cited by 99 publications

(99 citation statements)

References 17 publications

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“…[41][42][43]49,50 Several studies have identified patients with pulmonary brucellosis and pleural effusions. [51][52][53][54][55] Although we identified 1 (11.1%) patient with brucellosis and pleural effusion, it was not a consistent finding in our cohort.…”

Section: Discussionmentioning

confidence: 75%

Brucellosis among Hospitalized Febrile Patients in Northern Tanzania

Bouley

Biggs²,

Stoddard³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Abstract. Acute and convalescent serum samples were collected from febrile inpatients identified at two hospitals in Moshi, Tanzania. Confirmed brucellosis was defined as a positive blood culture or a 4-fold increase in microagglutination test titer, and probable brucellosis was defined as a single reciprocal titer 160. Among 870 participants enrolled in the study, 455 (52.3%) had paired sera available. Of these, 16 (3.5%) met criteria for confirmed brucellosis. Of 830 participants with 1 serum sample, 4 (0.5%) met criteria for probable brucellosis. Brucellosis was associated with increased median age (P = 0.024), leukopenia (odds ratio [OR] 7.8, P = 0.005), thrombocytopenia (OR 3.9, P = 0.018), and evidence of other zoonoses (OR 3.2, P = 0.026). Brucellosis was never diagnosed clinically, and although all participants with brucellosis received antibacterials or antimalarials in the hospital, no participant received standard brucellosis treatment. Brucellosis is an underdiagnosed and untreated cause of febrile disease among hospitalized adult and pediatric patients in northern Tanzania.

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Section: Discussionmentioning

confidence: 75%

Brucellosis among Hospitalized Febrile Patients in Northern Tanzania

Bouley

Biggs²,

Stoddard³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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“…Endocarditis was confirmed by auscultation of a cardiac murmur and detection of valvular vegetations using trans-thoracic echocardiography (15). Respiratory complications were defined by the protocol described by Pappas et al (16).…”

Section: Methodsmentioning

confidence: 99%

Human Brucellosis in Macedonia – 10 Years of Clinical Experience in Endemic Region

Bosilkovski¹,

Krteva²,

Dimzova³

et al. 2010

Croat Med J

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Aim To present our 10-year clinical experience with brucellosis patients at the University Clinic for Infectious Diseases and Febrile Conditions in Skopje, Republic of Macedonia.Methods A total of 550 patients with brucellosis treated between 1998 and 2007 were retrospectively assessed for their demographic, epidemiological, and clinical characteristics and outcomes.Results Of the 550 patients, 395 (72%) were male. The median age was 34.5 years (range, 1-82). Direct contact with infected animals was recorded in 333 (61%) patients and positive family history in 310 (56%). The most frequently seen symptoms were arthralgia (438, 80%), fever (419, 76%), and sweating (394, 72%). The most common signs were fever and hepatomegaly, which were verified in 357 (65%) and 273 (50%) patients, respectively. Focal brucellosis was found in 362 patients (66%) and osteoarticular in 299 (54%). Therapeutic failures were registered in 37 (6.7%) patients. Of the 453 (82%) patients who completed a follow-up period of at least 6 months, relapses occurred in 60 (13%). ConclusionDue to non-specific clinical manifestation and laboratory parameters, brucellosis should be considered one of the differential diagnoses of any patient suffering from obscure involvement of various organs in a brucellosis-endemic region. High percentage of relapses and therapeutic failures in spite of the use of currently recommended therapeutic regimens indicates the seriousness of this zoonosis and the need to control it.

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“…Brucellosis can lead to the compromise of the peripheral nervous system, leading to radiculopathy 14 . Lung diseases are common after inhalation of aerosols with Brucella 15 . The inhalation occurs during manipulation of cultures or clinical samples containing bacteria.…”

Section: Clinical Findingsmentioning

confidence: 99%

“…The inhalation occurs during manipulation of cultures or clinical samples containing bacteria. Interstitial pneumonitis, pneumonia, bronchopneumonia, pleural effusion, and lung nodules are conditions related to Brucella infection 15 .…”

Section: Clinical Findingsmentioning

confidence: 99%