Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement

Gürsoy, Mustafa Ozan; Tursun, İrfan; Alpua, Mehmet; Solay, Aslı Haykir; Çobanlı, Müge Tokat; Demirtaş, Hale; Ercan, Gülten; Gürsoy, Semra; Kalçık, Macit; Karakoyun, Süleyman; Özkan, Mehmet

doi:10.5543/tkda.2015.72025

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…In other case studies, it has been reported that mycotic pseudoaneurysm usually is due to trauma to the arterial wall with subsequent contamination [6, 16–21]. The arterial segment might be disrupted when an invasive infection is able to directly lodge in the artery or the vasa vasorum, especially with an intimal defect in the arterial wall such as an arteriosclerotic plaque [6, 19, 20]. In our case, the arteriosclerotic plaques were on CTA imaging.…”

Section: Discussionmentioning

confidence: 65%

Endovascular treatment of thoracic aortic pseudoaneurysm due to brucellosis: a rare case report

Wang

Liu

et al. 2017

BMC Infect Dis

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BackgroundArterial damage is a known complication of brucellosis, but the occurrence of a thoracic aortic pseudoaneurysm secondary to brucellosis has not been previously reported.Case presentationA 65-year-old Chinese man presented with a pseudoaneurysm in the descending segment of the thoracic aorta that caused symptoms of chest pain and intermittent fever. He was diagnosed with a thoracic aortic pseudoaneurysm secondary to brucellosis based on a positive brucella serology test (standard-tube agglutination test) and imaging examination (computed tomography angiography). Anti-brucellosis treatment and covered stent graft implantation were attempted to eliminate the brucellosis and pseudoaneurysm, respectively, and were ultimately successful, with no symptoms after 6 months of follow-up.ConclusionEndovascular repair may be effective and safe for treating a thoracic aortic pseudoaneurysm resulting from brucellosis.

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Section: Discussionmentioning

confidence: 65%

Endovascular treatment of thoracic aortic pseudoaneurysm due to brucellosis: a rare case report

Wang

Liu

et al. 2017

BMC Infect Dis

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“…It has been shown that infections constitute a risk factor for atherosclerosis and contribute to the chronic inflammatory process through direct or indirect effects [ 13 , 14 , 26 – 30 ]. In addition, in the study of Gursoy et al [ 35 ], it was shown that endothelial functions are impaired in patients with Brucellosis.…”

Section: Discussionmentioning

confidence: 99%

The relationship between Brucella infection and aortic stiffness in children

Uygun

2024

North Clin Istanbul

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OBJECTIVE In this study, it was aimed to show whether Brucella infection, which causes various cardiovascular complications in children, can lead to an increase in aortic stiffness with a noninvasive method, echocardiography. METHODS Children who were diagnosed with Brucella infection and who had tachycardia, chest pain and murmur that were not related to body temperature increase during the treatment were evaluated cardiologically and had echocardiographic examination, were included in the study. Aortic strain, aortic distensibility measurement results and aortic stiffness index of the patients in the patient and control groups were calculated. RESULTS Our study included 53 cases with a mean age of 11.43±4.13 years in the patient group and 68 cases with a mean age of 10.16±3.61 years in the control group. We found that systolic blood pressure was lower in the patient group than in the control group (p=0.014). In the analysis of laboratory parameters, blood glucose level was found to be significantly higher in the patient group (p=0.001). In the statistical evaluation of aortic strain, aortic stiffness index and aortic distensibility measurement results between the patient and control groups, no statistically significant difference was found between the groups (p=0.287, p=0.784, p=0.208). CONCLUSION In our study, where we tried to show a new parameter that could contribute to the increase in aortic stiffness, the results showed that Brucella infection was not a factor that increased aortic stiffness in the pediatric age group.

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“…For this reason, it has been suggested that the indirect effect of cytokines or toxins may cause an immune reaction to brucella antigen on the vascular walls, as well as direct endothelial damage and damage to the vascular endothelium [ 18 , 19 ]. Gürsoy et al [ 20 ] stated that it can disrupt endothelial functions in patients with brucella infection without causing chronic symptoms. It has been reported that some microorganisms such as Chlamydia pneumoniae and Human cytomegalovirus can cause endothelial dysfunction by affecting the artery walls [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Investigation of serum ischemic-modified albumin, galectin-3, paraoxonase-1, and myeloperoxidase activity levels in patients with acute brucellosis

Dündar

2023

Redox Report

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Objectives: Infection remains current as an important discussion topic in the etiological factors of atherosclerosis. Ischemic-modified albumin (IMA), galectin-3 (gal-3), paraoxonase-1 (PON-1), and myeloperoxidase (MPO) are biomolecules that play an important role in the pathogenesis of atherosclerosis. Our aim is to investigate serum IMA, gal-3, PON-1, and MPO activity in acute brucellosis infection. Materials and Methods: Forty patients with acute brucellosis and 40 healthy individuals were included in the study. Serum IMA, gal-3, PON-1, and MPO activity were analyzed by the ELISA method. Results: In acute brucellosis infection, serum gal-3, IMA, and MPO activities were found to be significantly increased compared to the control group, and PON-1 activity was found to be significantly decreased compared to the control group ( p < 0.001). There was a positive correlation between serum IMA, and MPO activity ( r = 0.707 p = 0.000) and a negative correlation ( r = −0.943, p = 0.000) between PON-1 activity. There was a positive correlation between serum gal-3 and MPO activity ( r = 0.683, p = 0.000) and IMA level ( r = 0.927, p = 0.000) and a negative correlation between PON-1 activity ( r = −0.951, p = 0.000). Conclusion, it was found that serum gal-3, IMA levels and MPO activity increased, while PON-1 activity decreased. These results showed that the oxidant-anti-oxidant balance is impaired in acute brucellosis infection. In addition, these results indicate that brucella infection may be increase the risk of atherosclerosis. Further studies are needed to support our findings.

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Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement

Abstract: Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement.

Cited by 3 publications

References 28 publications

Endovascular treatment of thoracic aortic pseudoaneurysm due to brucellosis: a rare case report

Endovascular treatment of thoracic aortic pseudoaneurysm due to brucellosis: a rare case report

The relationship between Brucella infection and aortic stiffness in children

Investigation of serum ischemic-modified albumin, galectin-3, paraoxonase-1, and myeloperoxidase activity levels in patients with acute brucellosis

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