Brucellosis in human and domestic animals in Bangladesh: A review

Rahman, Md. Siddiqur; Sarker, Roma Rani; Melzer, Falk; Sprague, Lisa D.; Neubauer, Heinrich

doi:10.5897/ajmr2014.7074

Cited by 8 publications

(3 citation statements)

References 18 publications

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“…Additionally, Brucellosis is capable of being transmitted by fomites. The Brucella organism can survive for several months in water, aborted fetuses, manure, hay, contaminated equipment and clothes, and especially in conditions with high humidity, low temperature, and no sunlight [72]. Similar environmental impacts have been revealed by a macro-level study, where lower temperature and less sunshine in winter and spring, and a 1-2-month incubation period have been associated with epidemic peaks from March to August, especially in May [60].…”

Section: Discussionmentioning

confidence: 65%

Modeling the current and future distribution of Brucellosis under climate change scenarios in Qinghai Lake basin, China

Arotolu,

Wang,

et al. 2023

Acta Veterinaria

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Bruce llosis is a bacterial disease caused by various Brucella species, which infect primarily cattle, swine, goats, sheep, and dogs. The disease is typically transmitted to humans through direct contact with diseased animals, consumption of contaminated animal products, or inhalation of airborne pollutants. The majority of cases are caused by consuming unpasteurized goat or sheep milk or cheese. Based on observed Brucellosis occurrence data and ecogeographic variables, a MaxEnt algorithm was used to model the current and future distribution of Brucellosis in Qinghai Lake basin, P.R. China. Our model showed the Brucellosis current distribution and predicts suitable habitat shifts under future climate scenarios. In the new representatives; SSP 2.6 and SSP 4.5 for the year 2050s and 2070s, our model predicts an expansion in the current suitable areas. This indicates that under the possible climate changes in the future, the living space of Brucellosis in Qinghai Lake basin China will expand significantly. Ecogeographic variables that contributed significantly to the distribution of Brucellosis in Qinghai Lake basin are revealed by our model. The results of our study will promote comparisons with future research and provide a new perspective to inform decision-making in the field of public health in Qinghai province.

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Section: Discussionmentioning

confidence: 65%

Modeling the current and future distribution of Brucellosis under climate change scenarios in Qinghai Lake basin, China

Arotolu,

Wang,

et al. 2023

Acta Veterinaria

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“…29,39 This disease has been controlled and eradicated in some developed countries in their cattle herd but it is still widespread endemic disease in most of the developing countries including Bangladesh. 20,21 Bovine brucellosis has become a serious problem in Indian dairy cattle due to band of slaughtering cattle because of religion ground, social system and animal husband practices. 40 It has been estimated to be BDT 60 million economic losses due to brucellosis in 1983 41 and more recently it has been estimated as BDT 48.4364 million (US $ 0.61million) annually only from Mymensingh district in Bangladesh.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Haemato-Biochemical and Therapeutic Responses of Chronic Brucellosis in Crossbred Dairy Cows in Bangladesh

Maruf¹,

Yasmin²,

Yeasmin³

et al. 2019

JVMOHR

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Background: Sero-molecular methods have been used for the study on the prevalence and economic impact of brucellosis in Bangladesh. The physio-pathological effects and therapeutic trials against brucellosis in animals or humans could not be traced in the available inland literature. Objectives: This study was conducted to determine the sero-prevalence and haemato-biochemical and therapeutic responses in Brucella-infected dairy crossbred cows. Materials and Methods: Sera samples of 552 cross-bred dairy cows of Military Dairy Farm, Jessore and smallholder dairy farms of Sirajgonj and Dhaka were initially screened for Brucella infection with Rapid kit test (RKT) and Rose Bengal test (RBT) and positive samples were tested further with ELISA and PCR for confirmatory diagnosis during the period from January 2018 to June 2019. Out of 11 all tests positive cows, of which four had history of abortion were selected for therapeutic trials with combined long acting oxytetracycline @ 25 mg/kg BW 16 doses at 72 hours intervals and streptomycin @ 25 mg / kg BW 10 doses at 24 hours interval injections. Blood samples of all the Brucella negative control and pre- and post-treatment stages of all the Brucella-infected cows were tested for haemato-biochemical changes and Brucella antibody responses by using ELISA and PCR. Results: Of the 552 sera screened for Brucella infection, of which 18 (3.26%) cows were found positive with the RKT, RBPT and ELISA, whereas only 11 (1.99%) samples showed positive with PCR. The haemato-biochemical values between Brucella-negative and positive cows and antibiotic pre-treated and post-treated values of Brucella-infected cows were compared and discussed. The antibody titer decreased with antibiotic treatment and increased on with-drawl of the antibiotic at 180 days which indicates that antibiotics only effective against bacteremic form not intracellular stage that caused to relapse. However, of the four treated cows, one became pregnant on artificial insemination with normal reproductive cycle which needs to explore its status in further research. Conclusions: The haemato-biochemical values in cows affected with sub-clinical brucellosis can determine the extent of harmful effects on the health of cows. Therapy with multiple antibiotics for long period, absence of effective vaccines and the most expensive quarantine and ‘test and slaughter’ methods, brucellosis remains as a challenge for its control and eradication in developing world. Human patients affected with brucellosis is treated with antibiotics with overall neglecting the animal reservoir of Brucella infection, therefore ‘One Health’ approach would be required to control this disease.

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“…2 There are several reports on seroprevalence, sero-epidemiology, sero-molecular epidemiology, risk factors, zoonotic importance and review of brucellosis in human and animals have been published from Bangladesh. [19][20][21][22] In addition, molecular detection of Brucella sp. from milk of sero-negative cattle, 23 isolation and genetic characterization of B. abortus biovar 3 from dairy cattle, 24,25 haemato-biochemical and therapeutic responses of chronic brucellosis in crossbred dairy cows, 26 comparison of humoral immune response (HIR) in indigenous cattle immunized with heat inactivated B. abortus biovar 3 and RB 51 vaccines 27,28 and HIR between indigenous cattle and indigenous buffaloes immunized with RB 51 vaccine 29 have been reported from Bangladesh.Report on the immunization and immunological response with B. abortus RB51 strain vaccine in cross-bred heifers is lacking in inland literature.…”

Section: Introductionmentioning

confidence: 99%

Humoral Immune Response in Cross-Bred Heifers Immunized With Brucella Abortus Strain Rb51 Vaccine in Military Dairy Farm of Bangladesh

Rahman¹,

Rahman²,

Rahman³

et al. 2020

JVMOHR

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Background: Brucellosis is a chronic zoonotic disease with negligible mortality rate that might be the reason not to attract the concerned authority to prevent and eradicate it in low income endemic countries. Recently, it has been recognized as a re-emerging zoonotic disease not only in low income countries but also its eradicated developed world. Objective: The main objective was to determine the humoral immune response (HIR) in crossbred dairy heifers immunized with Brucella abortus strain RB51 vaccine by using indirect ELISA Materials and Methods: Each of the 20 randomly selected B. abortus sero-negative crossbred (Holstein-Friesian  Local) dairy heifers aged between 4 to 8 months old at the Military Dairy Farm received 2.0 ml imported commercial B. abortus SRB51 strain vaccine subcutaneously in the neck region at day 0 and then booster dose at 60 days after first vaccination with similar dose and route during the period from June to October 2020. Each of the collected serum samples of 20 heifers at day 0, 7, 14, 21, 28, 60, 90, 120 and 150 was tested to detect the antibody status by using commercial indirect ELISA kit. Results: The humoral immune response (HIR) in terms of antibody levels detected by OD values in the serum of immunized cross-bred dairy heifers by using B. abortus strain RB51 commercial vaccine resulted 0.097  0.0032 (mean  SE) OD value at 0 day (i.e. pre-immunization) and 0.108 ± 0.0032 at 7th day. After that, the OD value started to rise from day 14 (OD value 0.124 ± 0.0032) and reached to a peak level at 60 days (OD value 0.223  0.0032) with the initial vaccination. Booster vaccination inoculated at 60 days resulted peak antibody level in terms of OD value (0.313  0.0032) at the day 90 and then the antibody level started to decline from 120 days (OD value 0.242  0.0032) to 150 days (OD value 0.199 0.0032) in cross-bred dairy heifers. Conclusions: This study suggests that the commercial B. abortus RB51 strain vaccine has induced satisfactory HIR with initial inoculation and significantly higher HIR produced with a booster dose in crossbred heifers by using commercial I-ELISA. The presence of Brucella antibodies have importance on sero-diagnosis whereas the cell mediated immunity (CMI) plays major role in protection against brucellosis which needs further investigation in cross-bred heifers in Bangladesh. Keywords: Brucellosis, SRB51 vaccine, Humoral immune response, I-ELISA, Cross-bred heifers, Bangladesh

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Brucellosis in human and domestic animals in Bangladesh: A review

Cited by 8 publications

References 18 publications

Modeling the current and future distribution of Brucellosis under climate change scenarios in Qinghai Lake basin, China

Modeling the current and future distribution of Brucellosis under climate change scenarios in Qinghai Lake basin, China

Assessment of Haemato-Biochemical and Therapeutic Responses of Chronic Brucellosis in Crossbred Dairy Cows in Bangladesh

Humoral Immune Response in Cross-Bred Heifers Immunized With Brucella Abortus Strain Rb51 Vaccine in Military Dairy Farm of Bangladesh

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