Brucellosis in pregnancy: results of multicenter ID-IRI study

İnan, Asuman; Erdem, Hakan; Elaldı, Nazif; Gülsün, Serda; Karahocagil, Mustafa Kasım; Pekok, Abdullah Umut; Ulug, Mehmet; Tekin, Recep; Bosilkovski, Mile; Kaya, Şafak; Haykir-Solay, Asli; Demırdal, Tuna; Kaya, Selçuk; Sünnetçioğlu, Mahmut; Şener, Alper; Tosun, Selma; Aydin, Emsal; Ural, Serap; Yamazhan, Tansu; Muhçu, Murat; Ayaslioglu, Ergin; Bilgic-Atli, Seval; Erbay, Ayşe; Ergen, Pınar; Kadanalı, Ayten; Şahin, Suzan; Şahin-Horasan, Elif; Avcı, Ali; Çağ, Yakup; Beeching, Nicholas J.

doi:10.1007/s10096-019-03540-z

Cited by 16 publications

(30 citation statements)

References 21 publications

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“…Obstetric outcomes are manifested as favorable (full-term delivery) and unfavorable (abortion, IUFD, and preterm delivery). Unfavorable obstetric outcomes were found in 34 out of 242 (14%) pregnant women suffering from brucellosis [23]. In the same study, splenomegaly, vomiting, vaginal bleeding, anemia, elevated serum aspartate aminotransferase, oligohydramnios, history of taking medication other than brucellosis treatment during pregnancy, and Brucella bacteremia were the significant potential risk factors for unfavorable outcome [23].…”

Section: Obstetric Outcomementioning

confidence: 69%

“…Contrary to these findings, some contemporary data suggest that brucellosis has a significant role in adverse obstetric outcomes in humans, and they imply that Brucella species may indeed produce human abortions more frequently than other bacterial pathogens [25]. With the rate of adverse obstetric outcomes from 14% to 46%, brucellosis exceeds the rate that can be seen in the general population of pregnant women [13,21,23]. In the context of such assertions are positive culture isolates of Brucella spp.…”

Section: The Influence Of Human Brucellosis On Obstetric Outcomesmentioning

confidence: 97%

“…According to various reports, a seroprevalence of brucellosis during pregnancy varied between 1.5% (13 seropositive out of 890 pregnant women) [18], 3.5% (18 out of 513) in rural areas of Saudi Arabia [19], 5.8% (25 out of 429) in Pakistan [20], and 12.2% (55 out of 450) in another study from Saudi Arabia [21]. The cumulative incidence of brucellosis cases in pregnancy per 1000 delivered obstetrical discharges was estimated to be from 0.42 [22] to 3.3 [23].…”

Section: Historymentioning

confidence: 99%

“…In addition, Buzgan et al reported 17 pregnant women among 1028 patients with brucellosis (1.7%) [26], Kurdoglu et al reported 21 pregnant women out of 342 patients with brucellosis (6.1%) [22], Madkour' s study reported 30 pregnancies among 500 patients with brucellosis (6%) [27], while in the study of Glick et al 11 out of 114 patients (9.6%) were pregnant [28]. The largest recently published multicenter study found 242 (2.1%) pregnant women among 11,602 adult brucellosis patients [23].…”

Section: Historymentioning

confidence: 99%

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Human brucellosis in pregnancy – an overview

Bosilkovski

Arapović

Keramat

2019

Bosn J of Basic Med Sci

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Human brucellosis during pregnancy is characterized by significantly less pronounced adverse obstetric outcomes than in animals, but with remarkably more adverse obstetric outcomes when compared to healthy pregnant women. Seroprevalence of brucellosis in pregnancy and cumulative incidence of brucellosis cases per 1000 delivered obstetrical discharges in endemic regions were reported to be 1.5–12.2% and 0.42–3.3, respectively. Depending on the region, frequency of pregnant women in the cohorts of patients with brucellosis was from 1.5% to 16.9%. The most common and the most dramatic unfavorable outcomes during brucellosis in pregnancy are the obstetric ones, manifested as abortions (2.5–54.5%), intrauterine fetal death (0–20.6%) or preterm deliveries (1.2–28.6%), depending on the stage of pregnancy. Other unfavorable outcomes due to brucellosis are addressed to infant (congenital/neonatal brucellosis, low birth weight, development delay or even death), the clinical course of disease in mother and delivery team exposure. When diagnosed in pregnant women, brucellosis should be treated as soon as possible. Early administration of adequate therapy significantly reduces the frequency of adverse outcomes. Rifampicin in combination with trimethoprim-sulfamethoxazole for 6 weeks is the most commonly used and recommended regimen, although monotherapies with each of these two drugs are also widely used while waiting for the results from prospective randomized therapeutic trials. As no effective human vaccine exists, screening of pregnant women and education of all women of childbearing age about brucellosis should be compulsory preventive measures in endemic regions.

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Section: Obstetric Outcomementioning

confidence: 69%

Section: The Influence Of Human Brucellosis On Obstetric Outcomesmentioning

confidence: 97%

Section: Historymentioning

confidence: 99%

Section: Historymentioning

confidence: 99%

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Human brucellosis in pregnancy – an overview

Bosilkovski

Arapović

Keramat

2019

Bosn J of Basic Med Sci

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“…(2011) 20 Vilchez G (2015) 12 Ali S (2016) 50 Inan A (2019) 51 Country, time of study Notes: A, consumption of unpasteurized or infected dairy products or meat; B, stockbreeding or contact with animals; C, previous diagnosis in family members; D, previous diagnosis in neighbors; E, low socioeconomic class or rural areas; F, not literate. † Detailed in Table 2 high risk of being encountered with brucellosis in these areas.…”

Section: Discussionmentioning

confidence: 99%

<p>Different Clinical Manifestations of Human Brucellosis in Pregnant Women: A Systematic Scoping Review of 521 Cases from 10 Countries</p>

Liu¹,

Wei²,

Li³

et al. 2020

IDR

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Introduction: This systematic scoping review aims to assess the frequency and severity of clinical manifestations of pregnant women with brucellosis. Methods: Three literature databases, PubMed, Web of Science and China National Knowledge Infrastructure (CNKI), and two search engines (Google and Yahoo) were adopted to identify the relevant articles that published until 31 December 2019. Two investigators independently screened the publications and extracted the data; the case reports and case series which described at least two symptoms or clinical manifestations of pregnant women with brucellosis were included. Results: A total of 27 articles describing the information of 521 pregnant women with brucellosis were included. Serum agglutination test was the most common laboratory test in the diagnosis of brucellosis. A total of 36 clinical manifestations were extracted from the included articles, and the most common clinical manifestations were fever (400, 76.8%), joint pain/swelling/arthralgia (389, 74.7%), sweats (382, 73.3%), fatigue/asthenia/weakness (262, 50.3%) and back pain (189, 36.3%). Among the 32 included individual cases that with available obstetric outcome information, 10 (31.3%) suffered preterm delivery, 12 (37.5%) had an abortion and 3 (9.8%) had intrauterine fetal death. Conclusion: Brucellosis is popular and threatening for pregnant women. Regarding the localized body system complications, osteoarticular system was mostly involved, the obstetrics outcomes were severe among pregnant women with brucellosis. The detailed clinical and epidemiological characteristics in this scoping review may add a better and more complete understanding of the disease for both physicians and policy-makers, and provide evidence for timely diagnosis, adequate therapy and better prevention.

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