Brucellosis of the lung: case report and review of the literature

Theegarten, Dirk; Albrecht, Susanne; Tötsch, Martin; Teschler, Helmut; Neubauer, Heinrich; Dahouk, Sascha Al

doi:10.1007/s00428-007-0518-0

Cited by 21 publications

(10 citation statements)

References 21 publications

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“…Histological findings in pulmonary brucellosis cases vary, and the vast majority of information available in the literature is associated with chronic cases, but our data are consistent with the limited amount available, i.e. that inflammation is often lymphohistiocytic and/or neutrophilic (Theegarten et al , 2008). We did not observe progression to granulomatous inflammation, presumably because of the short duration of the study.…”

Section: Resultssupporting

confidence: 87%

A rhesus macaque (Macaca mulatta) model of aerosol-exposure brucellosis (Brucella suis): pathology and diagnostic implications

Yingst

Huzella

Chuvala

et al. 2010

Journal of Medical Microbiology

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The US Centers for Disease Control and Prevention lists Brucella as a potential bioterrorism threat requiring enhanced diagnostic capacity and surveillance (http://emergency.cdc.gov/bioterrorism/). Successful treatment and management of patients after exposure to biological threat agents depends on accurate and timely diagnosis, but many biothreat agents present with similar, vague clinical signs – commonly referred to as ‘flu-like illness’. Diagnosis of brucellosis is notoriously challenging, especially early in infection, and definitive diagnosis may require invasive methods, e.g. bone marrow biopsy. We studied the pathogenesis of Brucella suis aerosol infection in rhesus macaques in an effort to guide the diagnostic algorithm in case of possible intentional exposure of humans. Rhesus proved to be an excellent model for human brucellosis; the data showed that PCR DNA amplification testing of non-invasive diagnostic samples has the potential to definitively detect a point-source outbreak immediately and for several days after exposure.

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Section: Resultssupporting

confidence: 87%

A rhesus macaque (Macaca mulatta) model of aerosol-exposure brucellosis (Brucella suis): pathology and diagnostic implications

Yingst

Huzella

Chuvala

et al. 2010

Journal of Medical Microbiology

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“…Histological findings of brucellosis in chronic cases includes abscesses, granulomatous lesions (caseating or non-caseating) and non-specific inflammation (Ahmed et al, 2012). Grossly, granulomatous lesions and edema were observed in lungs in the present study, these types of lesions have been reported in humans (Theegarten et al, 2008). Clinical signs and macroscopic lesions are contrary to those reported earlier by Nasruddin et al (2014) in experimentally infected bucks with Br.…”

Section: Discussioncontrasting

confidence: 90%

“…In humans, respiratory impediments are mostly mild flu-like with sore throat and mild dry cough. May cause pneumonia and lung abscess whereas serious manifestations are rare (Theegarten et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Patho-Morphological Valuation of Acute Infection of Brucella melitensis in Goats

Shahzad

2018

PVJ

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Brucellosis caused by Brucella melitensis is an important zoonotic disease in the world. Brucella melitensis is the causative organism of caprine and ovine brucellosis characterized by abortion, retained placenta, orchitis which may induce infertility, epididymitis and rarely, arthritis in small ruminants. However, these lesions were regarded as chronic while acute patho-morphological lesions had not been described in goats earlier. This study investigates the histopathological lesions in organs of native goats of Pakistan acutely infected by Brucella melitensis. Grossly, granulomatous lesions and edema were observed in the lungs of the infected animals. Other organs including liver, spleen, heart and spleen showed no gross lesions during necropsy. Severe histological lesions were observed in the lungs and uterus of acutely infected goats. The organism was detected by PCR from liver, lungs, spleen, uterus, sub mandibular lymph nodes and bronchial lymph nodes. The organism was not detected by PCR from the kidneys, ovaries, mammary glands, supra mammary lymph nodes, internal ileac lymph nodes and scapular lymph nodes. It was concluded that Br. melitensis acute infection did not lead to clinical presentation, although the organism was well distributed in various organs of goats. The lesions were generalized, not limited to reproductive organs.

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“…Brucellosis is the most prevalent zoonotic disease worldwide, causing spontaneous abortion and fetal death in animals and severe flu-like symptoms, focal complications, and often, chronic disease in humans (7,11,22,27,40,41,49,50). Brucella species are typically transmitted to humans through consumption of unpasteurized dairy products or exposure to fluids or tissues from infected animals (45,49).…”

mentioning

confidence: 99%

Characterization of Novel Brucella Strains Originating from Wild Native Rodent Species in North Queensland, Australia

Tiller

Gee

Frace

et al. 2010

Appl Environ Microbiol

101

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We report on the characterization of a group of seven novel Brucella strains isolated in 1964 from three native rodent species in North Queensland, Australia, during a survey of wild animals. The strains were initially reported to be Brucella suis biovar 3 on the basis of microbiological test results. Our results indicated that the rodent strains had microbiological traits distinct from those of B. suis biovar 3 and all other Brucella spp. To reinvestigate these rodent strains, we sequenced the 16S rRNA, recA, and rpoB genes and nine housekeeping genes and also performed multiple-locus variable-number tandem-repeat (VNTR) analysis (MLVA). The rodent strains have a unique 16S rRNA gene sequence compared to the sequences of the classical Brucella spp. Sequence analysis of the recA, rpoB, and nine housekeeping genes reveals that the rodent strains are genetically identical to each other at these loci and divergent from any of the currently described Brucella sequence types. However, all seven of the rodent strains do exhibit distinctive allelic MLVA profiles, although none demonstrated an amplicon for VNTR 07, whereas the other Brucella spp. did. Phylogenetic analysis of the MLVA data reveals that the rodent strains form a distinct clade separate from the classical Brucella spp. Furthermore, whole-genome sequence comparison using the maximal unique exact matches index (MUMi) demonstrated a high degree of relatedness of one of the seven rodent Brucella strains (strain NF 2653) to another Australian rodent Brucella strain (strain 83-13). Our findings strongly suggest that this group of Brucella strains isolated from wild Australian rodents defines a new species in the Brucella genus.Brucella species are facultative intracellular Gram-negative members of the Alphaproteobacteria class capable of causing brucellosis in a range of animal hosts, including domesticated livestock, wildlife, marine mammals, and humans (1,5,7,29,32,33,36,47). Brucellosis is the most prevalent zoonotic disease worldwide, causing spontaneous abortion and fetal death in animals and severe flu-like symptoms, focal complications, and often, chronic disease in humans (7,11,22,27,40,41,49,50). Brucella species are typically transmitted to humans through consumption of unpasteurized dairy products or exposure to fluids or tissues from infected animals (45, 49). Animals are primary hosts of all Brucella spp., which include Brucella abortus (cattle), B. canis (dogs), B. melitensis (goats, cows, and sheep), B. suis (swine), B. ovis (rams), and B. neotomae (desert rats) (3,7,8). Recently, three additional Brucella species have been recognized: B. pinnipedialis (seals), B. ceti (dolphins) (5), and B. microti. B. microti was initially isolated from the common vole in the Czech Republic (33, 35). In the mid-1980s, DNA-DNA hybridization studies demonstrated a very high level of genetic similarity (98.5%) among the Brucella spp., which led to the adoption of a monospecies concept for the Brucella genus, with all the species at that time renamed as biovars of ...

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Brucellosis of the lung: case report and review of the literature

Cited by 21 publications

References 21 publications

A rhesus macaque (Macaca mulatta) model of aerosol-exposure brucellosis (Brucella suis): pathology and diagnostic implications

A rhesus macaque (Macaca mulatta) model of aerosol-exposure brucellosis (Brucella suis): pathology and diagnostic implications

Patho-Morphological Valuation of Acute Infection of Brucella melitensis in Goats

Characterization of Novel Brucella Strains Originating from Wild Native Rodent Species in North Queensland, Australia

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