Brucellosis-related acute pancreatitis: A rare complication of a universal disease

Suvak, Burak; Dülger, Ahmet Cumhur; Karadaş, Sevdegül; Gönüllü, Hayriye; Bayram, Yasemin; Gönüllü, Edip; Batur, Abdüssamet; Aykaç, Mehmet Coşkun; Gündüz, Ali Mahir; Aytemiz, Enver; Güdücüoğlu, Hüseyin

doi:10.1177/0300060515583078

Cited by 8 publications

(5 citation statements)

References 14 publications

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“…Also, gastrointestinal involvement manifests as pancreatitis and cholecystitis. These complications have been rarely reported in patients with brucellosis (24,25). Also, in our study, epididymo-orchitis presented with testicular pain and dysuria, as reported in previous studies (26).…”

Section: Discussionsupporting

confidence: 87%

Epidemiology, Clinical and Laboratory Manifestations, and Outcomes of Brucellosis Among 104 Patients in Referral Hospitals of Tehran, Iran

Keyvanfar

Sali

Zamani

2021

Arch Clin Infect Dis

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Background: Brucellosis is the most common zoonotic disease in Iran, imposing a significant financial burden on the healthcare system. The diversity of non-specific clinical manifestations of this disease can lead to misdiagnosis or delayed diagnosis. Therefore, it is important to pay attention to other aspects of this disease. Objectives: This study aimed to determine the epidemiology, clinical and laboratory manifestations, and outcomes of brucellosis. Methods: In this cross-sectional study, brucellosis patients, admitted to three hospitals, affiliated to Shahid Beheshti University of Medical Sciences (Tehran, Iran) from April 2015 to September 2020, were examined. The patients' medical records were reviewed for epidemiological, clinical, and laboratory findings. The outcomes of the disease were evaluated by phone calls. Results: Of the 104 patients included in this study, 53.8% were male, and 46.2% were female. The mean age of the patients was 43.07 ± 18.521 years. Unpasteurized dairy consumption and contact with livestock were reported in 60.6 and 27.9% of the patients, respectively. Also, 23.1% of the patients had high-risk occupations. The most common symptoms included fever (80.8%), chills (58.7%), backache (55.8%), and sweating (51%). The most common complication was osteoarticular involvement (21.2%), followed by neurobrucellosis (6.7%). Elevated alkaline phosphatase (89.7%), anemia (67.3%), increased C-reactive protein (57.7%), and increased erythrocyte sedimentation rate (48.1%) were common laboratory findings. The rates of improvement, treatment failure, and relapse were 86.9, 9.1, and 4%, respectively. There was no significant relationship between the rate of improvement and the antibiotic regimen. However, the most common cause of treatment failure was the patient’s poor compliance with treatment. Conclusions: The diversity of non-specific clinical manifestations of brucellosis is a diagnostic challenge. Therefore, physicians must request laboratory tests to evaluate brucellosis after taking a precise epidemiological and clinical history of suspected cases.

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Section: Discussionsupporting

confidence: 87%

Epidemiology, Clinical and Laboratory Manifestations, and Outcomes of Brucellosis Among 104 Patients in Referral Hospitals of Tehran, Iran

Keyvanfar

Sali

Zamani

2021

Arch Clin Infect Dis

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“…Sporadic cases of AP due to gastrointestinal bacteria like Campylobacter jejuni [ 35 , 36 ], Yersinia enterocolitica [ 37 , 38 ], Yersinia pseudotuberculosis [ 38 ], Brucella [ 39 ], and Nocardia [ 40 ] have been reported in the literature [ 6 ].…”

Section: Bacterial Causes Of Apmentioning

confidence: 99%

Review of Infectious Etiology of Acute Pancreatitis

2017

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While gallstones and alcoholism are widely known to be the most common causative agents of acute pancreatitis, about 10% of cases are thought to be caused by infectious microorganisms. These microorganisms include viruses (e.g. mumps, Coxsackie B, and hepatitis), bacteria (e.g. Mycoplasma pneumoniae and leptospirosis), and parasites (e.g. Ascaris lumbricoides, Fasciola hepatica, and hydatid disease). Each organism causes acute pancreatitis through diverse mechanisms. The review is primarily conducted in an attempt to provide a better understanding of the possibility of acute pancreatitis presenting as a complication relating to these organisms, and the aim is to guide future diagnoses, management, and predictions of complications.

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“…Inflammatory changes are probably due to a direct effect of the bacteria in the blood stream, causing the local activation of inflammatory mediators, and an indirect effect through a systemic hypercoagulable state [138]. Legionellosis [140] and brucellosis [141] infections caused by gastrointestinal pathogens (Campylobacter jejuni, Yersinia enterocolitica) were reported in association with AP [142,143].…”

Section: Bacterial Infectionsmentioning

confidence: 99%

Idiopathic acute pancreatitis: a review on etiology and diagnostic work-up

Blanco

Gesuale

Varanese

et al. 2019

Clin J Gastroenterol

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Acute pancreatitis (AP) is a common disease associated with a substantial medical and financial burden, and with an incidence across Europe ranging from 4.6 to 100 per 100,000 population. Although most cases of AP are caused by gallstones or alcohol abuse, several other causes may be responsible for acute inflammation of the pancreatic gland. Correctly diagnosing AP etiology is a crucial step in the diagnostic and therapeutic work-up of patients to prescribe the most appropriate therapy and to prevent recurrent attacks leading to the development of chronic pancreatitis. Despite the improvement of diagnostic technologies, and the availability of endoscopic ultrasound and sophisticated radiological imaging techniques, the etiology of AP remains unclear in ~ 10-30% of patients and is defined as idiopathic AP (IAP). The present review aims to describe all the conditions underlying an initially diagnosed IAP and the investigations to consider during diagnostic work-up in patients with non-alcoholic non-biliary pancreatitis.

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Brucellosis-related acute pancreatitis: A rare complication of a universal disease

Cited by 8 publications

References 14 publications

Epidemiology, Clinical and Laboratory Manifestations, and Outcomes of Brucellosis Among 104 Patients in Referral Hospitals of Tehran, Iran

Epidemiology, Clinical and Laboratory Manifestations, and Outcomes of Brucellosis Among 104 Patients in Referral Hospitals of Tehran, Iran

Review of Infectious Etiology of Acute Pancreatitis

Idiopathic acute pancreatitis: a review on etiology and diagnostic work-up

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