Brugada Electrocardiogram Pattern Induced by Cannabis

Romero-Puche, Antonio J.; Trigueros-Ruiz, Natalia; Cerdán-Sánchez, M. Carmen; Pérez-Lorente, Fernando; Roldán, Diego; Vicente-Vera, Tomás

doi:10.1016/j.rec.2012.01.015

Cited by 22 publications

(14 citation statements)

References 5 publications

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“…Additionally, review articles refer to the first hour after cannabis smoking as the riskiest hour, with the risk falling rapidly thereafter . Several authors have reported cases of CVD in proximity to cannabis use, sometimes supported by a positive urinalysis, as reported in Table . However, a positive cannabis finding is common up to 5 days after smoking and, in heavy smokers, positivity may be present for weeks or months .…”

Section: Introductionmentioning

confidence: 99%

Coronary thrombosis and marijuana smoking: a case report and narrative review of the literature

Marchetti

Matteis

et al. 2015

Drug Testing and Analysis

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We encountered evidence of myocardial infarction due to coronary thrombosis in an autopsy of an occasional marijuana smoker. These findings prompted us to perform a narrative review of the literature to determine when post-mortem toxicological tests may support a temporal relationship between marijuana smoking and cardiovascular disease. Toxicological examination showed the presence of Δ-9-tetrahydrocannabinol, its main metabolite and cannabinol in blood and urine. Quali-quantitative analysis revealed that Δ-9-tetrahydrocannabinol was taken within 2 h of the onset of cardiovascular symptoms, according to circumstantial data. Post-mortem toxicological results must take into account the degradation and post-mortem redistribution of analytes. However, for any inference about the specific cardiovascular triggering effect of Δ-9-tetrahydrocannabinol intake, we maintain that cannabinoid analysis in blood samples must be considered an essential requirement to estimate the time of last intake and avoid incomplete documentation. The literature, combined with the present case report, highlights an association between marijuana use and negative cardiovascular events, although few authors have supported their conclusions with toxicological results. Thus, additional research is needed.

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Section: Introductionmentioning

confidence: 99%

Coronary thrombosis and marijuana smoking: a case report and narrative review of the literature

Marchetti

Matteis

et al. 2015

Drug Testing and Analysis

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“…Cardiac arrhythmia including atrial fibrillation [4,5,6], atrial flutter [7], II degree AV block [8], ventricular fibrillation [9], ventricular tachycardia [10,11,12], asystole [13,14] have been reported with marijuana use.Despite these recent reports the effect of marijuana and its active components on ion-channels in general, cardiac ion channels in particular is largely lacking. Previous investigators have reported a case of acute marijuana intoxication that presented with Brugada like-ST segment elevation [15,16,17,18]. We here present a case of type I Brugada pattern associated with marijuana use.…”

Section: Introductionmentioning

confidence: 70%

Marijuana Induced Type I Brugada Pattern: A Case Report

Kariyanna

Jayarangaiah

Hegde

et al. 2018

AJMCR

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Marijuana is the most common drug of abuse in the United States. Marijuana acts on cannabinoid receptors CB1, CB2 and another distinct endothelial receptor. Marijuana is known to cause tachycardia, hypotension and hypertension. Various arrhythmias including atrial fibrillation, atrial flutter, II degree AV block, ventricular fibrillation, ventricular tachycardia, asystole and brugada pattern associated with marijuana use have been reported. We here present an interesting case of Type I Brugada pattern in electrocardiography (ECG) in a 36 year old healthy African American male who presented after smoking four joints. Urine toxicology test proved marijuana use. Acute coronary syndrome was ruled out, coronary angiogram revealed normal coronaries, 2D echocardiogram showed no evidence of structural heart disease. Upon resolution of Brugada pattern in ECG, procainamide challenge performed in electrophysiology laboratory did not induce Brugada pattern. Patient was asked to return to hospital if he developed fever that did not resolve with antipyretics. Further studies are required to to understand the effect of marijuana on cardiac ion channels.

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“…Data on heart transplant recipients of donors who used marijuana are more limited. Cannabis‐associated cardiovascular disease has been well described, resulting in sudden death and arrhythmias . However, two studies evaluating recipients of heart donors with histories of MJ use did not show differences in survival.…”

Section: Resultsmentioning

confidence: 99%

Marijuana use in transplantation: A call for clarity

Levi¹,

Montague²,

Thurstone

et al. 2019

Clinical Transplantation

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Transplant centers have varying policies for marijuana (MJ) use in donors, transplant candidates, and recipients. Rationales for these differences range from concerns for fungal complications, impaired adherence, and drug interactions. This paper reviews the current status of MJ policies and practices in transplant centers and results of a survey sent to the American Society of Transplantation (AST) membership by the Executive Committee of the AST Infectious Diseases Community of Practice. The purpose of the survey was to compare policies and concerns of MJ use to actual observed complications. Of the 3321 surveys sent, 225 members (8%) responded. Transplant centers varied in their approval processes, differing even in organ types within the same institutions. Furthermore, there was discordance among transplant centers in their perceived risks of marijuana use as opposed to complications actually observed. An increasing number of states continue to legalize medical and recreational MJ resulting in widespread availability. Further research is needed to assess the validity of concerns for complications of MJ use in potential donors and recipients. Ultimately, standardized guidelines should be established based on studies and evidence-based criteria to assist transplant programs in their policies around the use of cannabis in their donors and recipients.

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Brugada Electrocardiogram Pattern Induced by Cannabis

Cited by 22 publications

References 5 publications

Coronary thrombosis and marijuana smoking: a case report and narrative review of the literature

Coronary thrombosis and marijuana smoking: a case report and narrative review of the literature

Marijuana Induced Type I Brugada Pattern: A Case Report

Marijuana use in transplantation: A call for clarity

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