BsmI, TaqI, ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and risk of fracture in Caucasians: A meta-analysis

Ji, Guang-Rong; Yao, Meng; Sun, Chongyi; Li, Zhi-Hao; Han, Zhu

doi:10.1016/j.bone.2010.06.024

Cited by 58 publications

(38 citation statements)

References 38 publications

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“…In the VDR gene, four common restriction fragment length polymorphisms (BsmI, TaqI, ApaI, and FokI) have been associated with BMD. In this sense, VDR gene polymorphisms have been strongly associated with BMD in some studies [29,30]; however, recent metaanalysis study have shown conflicting results of the relationship between VDR polymorphisms and BMD and founded only a modest but statistically significant association between lower frequency of BsmI bb genotypes and BMD in cases of bone fracture [31].…”

Section: Discussionmentioning

confidence: 98%

Alveolar bone level is not associated with vitamin D receptor gene polymorphism and bone density in mandible

Mesa

González

Souki³

et al. 2011

Clin Oral Invest

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The objective of this study was to determine, using digital panoramic radiographs, whether the bone level at the alveolar crest is related to the mandibular bone density and/or to vitamin D receptor (VDR) gene polymorphisms. We analyzed 319 digital panoramic radiographs from the same number of patients. Alveolar bone level was expressed as percentage of root length. The mandibular cortical width index was calculated as a measure of mandibular bone density, and, in 72 randomly selected cases, the haplotype of the VDR gene (BsmL) was determined by polymerase chain reaction. Alveolar bone level was not related to the mandibular cortical width index (p = 0.568) or VDR gene expression (p = 0.575). Bone loss was greater in smokers than in non-smokers (p = 0.036), and the mandibular cortical width index was higher in males (p = 0.04), the older age group (p = 0.032), and in those with more teeth (p = 0.01). Multivariate analysis confirmed the association between these variables and alveolar bone loss. Alveolar bone loss showed no significant relationship with the mandibular bone density evaluated on digital panoramic radiographs or with VDR genotype (BsmL) in Caucasian females and males aged under 47 years.

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Section: Discussionmentioning

confidence: 98%

Alveolar bone level is not associated with vitamin D receptor gene polymorphism and bone density in mandible

Mesa

González

Souki³

et al. 2011

Clin Oral Invest

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“…Through the genome of a single nucleotide polymorphism frequency analysis, the vitamin D receptor gene polymorphism should be more than 100 kinds [8,9]. We know vitamin D receptor gene polymorphisms mainly related to four single nucleotide polymorphisms (BsmI, TaqI, ApaI and FokI) from recent study [10]. Fang et al performed a meta-analysis relating BsmI or TaqI polymorphisms of the VDR gene with Osteoporosis risk [11].…”

Section: Introductionmentioning

confidence: 99%

The Association between Vitamin D Receptor FokI Gene Polymorphism and Osteoporosis in Postmenopausal Women: A Meta-Analysis

Zhang

Ning

et al. 2015

J Osteopor Phys Act

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Objective: The aim of this study was to quantitatively summarize the evidence for VDR FokI gene polymorphism and osteoporosis risk in postmenopausal women. Materials and methods:Electronic search at PubMed, EMBASE, Weipu database, and Wanfang database was conducted to select studies. Case-control studies containing available genotype frequencies of F/f were chosen, and Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this revelance. Results:The case-control studies including 2199 osteoporosis cases and 2231 controls were identified. Overall meta-analysis indicated that individuals with the homozygous ff genotype had increased risk of osteoporosis(Recessive model: OR=1.551, 95% CI: 1.035~2.325,p=0.034).In the stratified analysis, individuals with the ff genotype in the Recessive model had increased risk of osteoporosis in Asian subjects(OR=2.644, 95% CI: 1.583~4.419,p= 0.000),but not in Caucasian subjects(OR= 1.288, 95%CI: 0.783~2.118, p = 0.318) and Mixed subjects (OR= 0.885, 95%CI: 0.686~1.141, p =0.346). A symmetric funnel plot, the Begg-test (P=0.094) suggested that lack of publication bias. The studies conducted in each of the defined number of osteoporosis-had no effect of the FokI polymorphism on osteoporosis except for the ff versus Ff+FF genotype comparison for osteoporosis subgroup. Conclusion:In conclusion, our meta-analysis suggests that VDR Fok I genotype is associated with increased risk of osteoporosis in Asian but not in caucasian. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR Fok I polymorphism and osteoporosis.

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“…In fact, previous meta-analyses have suggested that the BB genotype is associated with lower BMD and greater fracture risk than bb [25, 26]. In a meta-analysis of 39 studies it was shown that postmenopausal women with the BB genotype had significantly lower BMD at the spine than women with the bb genotype [25].…”

Section: Discussionmentioning

confidence: 99%

Influence of vitamin D and estrogen receptor gene polymorphisms on calcium absorption: Bsm I predicts a greater decrease during energy restriction

Chang

Schlussel

Sukumar

et al. 2015

Bone

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Low calcium absorption is associated with low bone mass and fracture. In this study, we use gold standard methods of fractional calcium absorption (FCA) to determine whether polymorphisms of intestinal receptors, vitamin D receptor (VDR) and estrogen receptor α (ESR1), influence the response to energy restriction. Fractional calcium absorption was measured using dual stable isotopes (42Ca and 43Ca) in women given adequate calcium and vitamin D and examined at baseline and after 6 weeks of energy restriction or no intervention. After genotyping, the relationship between VDR and ESR1 genotypes/haplotypes and FCA response was assessed using several genetic models. One-hundred and sixty-eight women (53 ± 11 years of age) were included in this analysis. The ESR1 polymorphisms, PvuII and XbaI and VDR polymorphisms (TaqI, ApaI) did not significantly influence FCA. The BB genotype of the VDR polymorphism, BsmI, was associated with a greater decrease in FCA than the Bb/ bb genotype. Multiple linear regression showed that the BsmI polymorphism or the VDR haplotype, BAt, in addition to changes in weight and vitamin D intake explained ~16% of the variation in changes in FCA. In conclusion, the reduction in calcium absorption due to energy restriction is greatest for those with the BB genotype. Previous candidate gene studies show that VDR polymorphisms are associated with higher risk for osteoporosis, and the current study supports the notion that the BsmI polymorphism in intestinal VDR may be contributing to alterations in bone health.

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BsmI, TaqI, ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and risk of fracture in Caucasians: A meta-analysis

Cited by 58 publications

References 38 publications

Alveolar bone level is not associated with vitamin D receptor gene polymorphism and bone density in mandible

Alveolar bone level is not associated with vitamin D receptor gene polymorphism and bone density in mandible

The Association between Vitamin D Receptor FokI Gene Polymorphism and Osteoporosis in Postmenopausal Women: A Meta-Analysis

Influence of vitamin D and estrogen receptor gene polymorphisms on calcium absorption: Bsm I predicts a greater decrease during energy restriction

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