Influence of vitamin D and estrogen receptor gene polymorphisms on calcium absorption: Bsm I predicts a greater decrease during energy restriction

Chang, Brian; Schlussel, Yvette; Sukumar, Deeptha; Schneider, Stephen H.; Shapses, Sue A.

doi:10.1016/j.bone.2015.07.011

Cited by 11 publications

(6 citation statements)

References 47 publications

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“…However, the author proposed that further studies with larger sample sizes from wider geographical areas are required for validation. Recently, Chang et al (2015) reported the Bsm I polymorphism in intestinal VDR may contribute to alterations in bone health. There is new evidence regarding the role of CD40 and CDL40 systems in the homeostasis of bone marrow cells.…”

Section: Major Biological Pathways Involved In Osteogenesis Related Tmentioning

confidence: 99%

An insight into the paradigms of osteoporosis: From genetics to biomechanics

et al. 2019

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Considered as one of the major epidemics of the 21st century, osteoporosis affects approximately 200 million people globally, with significant worldwide impact on rates of morbidity and mortality and massive socioeconomic burdens. Mainly characterized by decreased bone mineral density (BMD) and increased risk of bone fragility/deterioration, this devastating silent epidemic typically has no symptoms until a fracture occurs. The multifactorial disease, osteoporosis is instigated by complex interactions between genetic, metabolic and environmental factors, with severe impact on the biomechanics of the musculoskeletal system. This article provides a review of the epidemiology, genetic and biomechanical aspects of primary osteoporosis. The review begins with a summary of the epidemiology and global prevalence of osteoporosis. Sections 1 and 2 discuss the genetic associations and molecular signaling pathways involved in normal and pathological osteogenesis while Section 3 explores the biomechanics of osteoporosis and its quantitative damaging effects on critical bone mechanical properties, and associated bone remodeling. Overall, this review summarizes the recent findings about osteoporosis and emphasizes the importance of an integrative holistic approach in investigating osteoporosis towards providing better informed, more effective preventive and treatment modalities. Importantly, this work also explores the limited available literature on the various aspects of osteoporosis in the United Arab Emirates (UAE), Gulf Cooperation Council (GCC), and Middle East despite its alarming prevalence in the region, and highlights the need for further research and studies taking into consideration the importance of the vitamin D receptor ( VDR ) gene influencing the development of osteoporosis.

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Section: Major Biological Pathways Involved In Osteogenesis Related Tmentioning

confidence: 99%

An insight into the paradigms of osteoporosis: From genetics to biomechanics

et al. 2019

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“…Mechanistically, Arai et al [13] showed that the A allele of Cdx2 has a higher transcriptional activity of VDR than the G allele in vitro. To our knowledge, however, there is no experimental study investigating whether the Cdx2 polymorphism affects calcium absorption, despite it having been investigated for other VDR polymorphisms (BsmI, TaqI, and ApaI) using dual stable isotopes [45,46]. It was reported that the Cdx2 polymorphism modified the positive association between calcium intake and prostate cancer risk in White [47] and African American [48] people.…”

Section: Discussionmentioning

confidence: 99%

Effect of Cdx2 Polymorphism on the Relationship between Dietary Calcium Intake and Peak Bone Mass in Young Japanese Women

et al. 2020

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Studies investigating the effect of the caudal-type homeobox protein 2 (Cdx2) polymorphism in the vitamin D receptor gene and calcium intake on bone mass have shown inconsistent results. This study investigated whether the effect of calcium intake on peak bone mass is affected by Cdx2 polymorphism in young Japanese women. A cross-sectional study of 500 young women was conducted. Dietary intake was assessed by the Food Frequency Questionnaire. The osteo sono-assessment index (OSI), assessed by the qualitative ultrasound method, was used as a bone mass index. The subjects were divided into two groups by the median calcium intake. The OSI was not different among Cdx2 genotypes and between calcium groups (p = 0.960, p = 0.191, respectively). The interaction between calcium and Cdx2 genotypes on the OSI approached significance (GG versus GA and AA genotypes, p = 0.092). The difference in the OSI between calcium groups was significant in the GG genotype (p = 0.028), but not in the GA or AA genotypes (p = 0.501, p = 0.306, respectively). Adjustment for covariates (body mass index and physical activity) did not change the results. In conclusion, the relationship between dietary calcium intake and peak bone mass may vary according to Cdx2 polymorphism.

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“…The reason for this may be associated with VDR signal enhancement although we could not identify the specific underlying mechanism. Additionally, previous studies demonstrated that VDR polymorphism is associated with calcium absorption 24 ) . Taking these facts into account, we speculate that one explanation for the characteristics of our new CKD model is susceptibility to VDRA due to VDR gene polymorphism.…”

Section: Discussionmentioning

confidence: 99%

Newly Developed Rat Model of Chronic Kidney Disease–Mineral Bone Disorder

Watanabe

Fujii

Goto

et al. 2018

JAT

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Aim: Chronic kidney disease–mineral bone disorder (CKD–MBD) is associated with all-cause and cardiovascular morbidity and mortality in patients with CKD. Thus, elucidating its pathophysiological mechanisms is essential for improving the prognosis. We evaluated characteristics of CKD–MBD in a newly developed CKD rat model.Methods: We used male Sprague–Dawley (SD) rats and spontaneously diabetic Torii (SDT) rats, which are used as models for nonobese type 2 diabetes. CKD was induced by 5/6 nephrectomy (Nx). At 10 weeks, the rats were classified into six groups and administered with a vehicle or a low- or high-dose paricalcitol thrice a week. At 20 weeks, the rats were sacrificed; blood and urinary biochemical analyses and histological analysis of the aorta were performed.Results: At 20 weeks, hemoglobin A1c (HbA1c) levels, blood pressure, and renal function were not significantly different among the six groups. Serum calcium and phosphate levels tended to be higher in SDT-Nx rats than in SD-Nx rats. The urinary excretion of calcium and phosphate was significantly greater in SDT-Nx rats than in SD-Nx rats. After administering paricalcitol, serum parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) levels were significantly higher in SDT-Nx rats than in SD-Nx rats. The degree of aortic calcification was significantly more severe and the aortic calcium content was significantly greater in SDT-Nx rats than in SD-Nx rats.Conclusions: We suggest that our new CKD rat model using SDT rats represents a useful CKD–MBD model, and this model was greatly influenced by paricalcitol administration. Further studies are needed to clarify the detailed mechanisms underlying this model.

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Influence of vitamin D and estrogen receptor gene polymorphisms on calcium absorption: Bsm I predicts a greater decrease during energy restriction

Cited by 11 publications

References 47 publications

An insight into the paradigms of osteoporosis: From genetics to biomechanics

An insight into the paradigms of osteoporosis: From genetics to biomechanics

Effect of Cdx2 Polymorphism on the Relationship between Dietary Calcium Intake and Peak Bone Mass in Young Japanese Women

Newly Developed Rat Model of Chronic Kidney Disease–Mineral Bone Disorder

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