BTB and CNC homology 1 (Bach1) promotes human ovarian cancer cell metastasis by HMGA2-mediated epithelial-mesenchymal transition

Han, Wenyan; Zhang, Yiqun; Niu, Cong; Guo, Jr-Hung; Li, Jiajia; Wei, Xiangxiang; Jia, Minghan; Zhi, Xiuling; Yao, Liangqing; Meng, Dan

doi:10.1016/j.canlet.2019.01.003

Cited by 69 publications

(68 citation statements)

References 38 publications

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“…Accumulating data establish BACH1 as a critical facilitator of tumorigenesis and metastasis in breast (Lee et al, 2013), colon (Davudian et al, 2016b), prostate (Shajari et al, 2018) ovarian (Han et al, 2019), and lung (Lignitto et al, 2019;Wiel et al, 2019) cancer. Elevated levels of BACH1 expression have been linked to a higher risk of breast cancer recurrence in patients (Liang et al, 2012), whereas association with metastatic spread and poorer prognosis has recently been suggested in the case of human ovarian cancer (Han et al, 2019) and lung adenocarcinoma (Lignitto et al, 2019;Wiel et al, 2019). Ectopic expression of BACH1 in breast cancer cells promotes malignancy and metastasis, whereas its knockdown suppresses these processes.…”

Section: Discussionmentioning

confidence: 99%

“…ubiquitously expressed protein, as a tumor-promoting factor that acts via multiple intracellular signaling cascades (Alvarez & Woolf, 2011;Yun et al, 2011). Recently, higher levels of BACH1 were found to be associated with poor prognosis in human ovarian cancer (Han et al, 2019) and to promote lung cancer metastasis (Lignitto et al, 2019;Wiel et al, 2019). BACH1 has been established as a major regulator of breast cancer bone metastasis (Liang et al, 2012) and was postulated as a potential novel therapeutic candidate for cancer treatment (Davudian et al, 2016a;Lee et al, 2019).…”

Section: Bach1 Promotes Angiogenesis and Lymphangiogenesis During Tummentioning

confidence: 99%

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BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression

Cohen¹,

Tempelhof²,

Raz

et al. 2020

Life Sci. Alliance

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Angiogenesis and lymphangiogenesis are key processes during embryogenesis as well as under physiological and pathological conditions. Vascular endothelial growth factor C (VEGFC), the ligand for both VEGFR2 and VEGFR3, is a central lymphangiogenic regulator that also drives angiogenesis. Here, we report that members of the highly conserved BACH (BTB and CNC homology) family of transcription factors regulate VEGFC expression, through direct binding to its promoter. Accordingly, down-regulation of bach2a hinders blood vessel formation and impairs lymphatic sprouting in a Vegfc-dependent manner during zebrafish embryonic development. In contrast, BACH1 overexpression enhances intratumoral blood vessel density and peritumoral lymphatic vessel diameter in ovarian and lung mouse tumor models. The effects on the vascular compartment correlate spatially and temporally with BACH1 transcriptional regulation of VEGFC expression. Altogether, our results uncover a novel role for the BACH/VEGFC signaling axis in lymphatic formation during embryogenesis and cancer, providing a novel potential target for therapeutic interventions.

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Section: Discussionmentioning

confidence: 99%

Section: Bach1 Promotes Angiogenesis and Lymphangiogenesis During Tummentioning

confidence: 99%

BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression

Cohen¹,

Tempelhof²,

Raz

et al. 2020

Life Sci. Alliance

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“…Interestingly, developmentally regulated EMTs share many aspects with pathological EMTs of tumors [143][144][145]. It is important to note that the HMGA2 protein plays a similar role in tumors, where it concurs to promote EMT through the direct activation of Snai1/2 and Twist and the downregulation of E-cadherin [146][147][148][149][150][151][152][153][154][155][156]. It is feasible that HMGA2 cooperates and is recruited with different transcription factors in sequential steps of the EMT genetic program, in force of its capacity to interact with so many molecular partners [23,157].…”

Section: Hmga Genes In Xenopus Development: Focus On Neural Crest Andmentioning

confidence: 99%

HMGA Genes and Proteins in Development and Evolution

Vignali

Marracci

2020

IJMS

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HMGA (high mobility group A) (HMGA1 and HMGA2) are small non-histone proteins that can bind DNA and modify chromatin state, thus modulating the accessibility of regulatory factors to the DNA and contributing to the overall panorama of gene expression tuning. In general, they are abundantly expressed during embryogenesis, but are downregulated in the adult differentiated tissues. In the present review, we summarize some aspects of their role during development, also dealing with relevant studies that have shed light on their functioning in cell biology and with emerging possible involvement of HMGA1 and HMGA2 in evolutionary biology.

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“…We previously reported that BACH1 promotes the proliferation of MEFs transformed with H-Ras v12 and their tumor formation in a mouse transplantation model (Nakanome et al, 2013). Recently, BACH1 was found to promote the proliferation and/or metastasis of breast cancer and ovarian cancer cells (Han et al, 2019, Lee et al, 2014, Lee et al, 2019, Mansoori et al, 2019). BACH1 is therefore considered to have dual functions in cancers: promoting cell proliferation and cell death through ferroptosis.…”

Section: Discussionmentioning

confidence: 99%

Ferroptosis is programmed by the coordinated regulation of glutathione and iron metabolism by BACH1

Nishizawa

Matsumoto

Shindo

et al. 2019

Preprint

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1Ferroptosis is an iron-dependent programmed cell death resulting from alterations of 2 metabolic processes. However, its regulation and physiological significance remain to be 3 elucidated. By analyzing transcriptional responses of murine embryonic fibroblasts 4 exposed to the ferroptosis-inducer erastin, we found that a set of genes related to oxidative 5 stress protection was induced upon ferroptosis. We further showed that the transcription 6 factor BACH1 promoted ferroptosis by repressing the expression of a subset of 7 erastin-inducible genes involved in the synthesis of glutathione or metabolism of 8 intracellular labile iron, including Gclm, Gclc, Slc7a11, Hmox1, Fth1, Ftl1, and Slc40a1. 9 Compared with wild-type mice, Bach1 -/mice showed resistance to myocardial infarction, 10

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BTB and CNC homology 1 (Bach1) promotes human ovarian cancer cell metastasis by HMGA2-mediated epithelial-mesenchymal transition

Cited by 69 publications

References 38 publications

BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression

BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression

HMGA Genes and Proteins in Development and Evolution

Ferroptosis is programmed by the coordinated regulation of glutathione and iron metabolism by BACH1

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