2003
DOI: 10.1016/s1097-2765(03)00341-1
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BTB/POZ Domain Proteins Are Putative Substrate Adaptors for Cullin 3 Ubiquitin Ligases

Abstract: Cullins (CULs) are subunits of a prominent class of RING ubiquitin ligases. Whereas the subunits and substrates of CUL1-associated SCF complexes and CUL2 ubiquitin ligases are well established, they are largely unknown for other cullin family members. We show here that S. pombe CUL3 (Pcu3p) forms a complex with the RING protein Pip1p and all three BTB/POZ domain proteins encoded in the fission yeast genome. The integrity of the BTB/POZ domain, which shows similarity to the cullin binding proteins SKP1 and elon… Show more

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Cited by 306 publications
(293 citation statements)
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“…Several BTB proteins have been shown to be substrate receptors for Cullin 3 ubiquitin ligases (CDL3s) (Geyer et al, 2003;Pintard et al, 2003;Xu et al, 2003;Kobayashi et al, 2004;Zhang et al, 2004). Because KEL-8 contains a BTB domain, it might interact directly with CUL-3, the C. elegans Cullin 3 orthologue.…”
Section: Kel-8 Interacts With the Cul-3 Subunit Of Cullin 3 Ubiquitinmentioning
confidence: 99%
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“…Several BTB proteins have been shown to be substrate receptors for Cullin 3 ubiquitin ligases (CDL3s) (Geyer et al, 2003;Pintard et al, 2003;Xu et al, 2003;Kobayashi et al, 2004;Zhang et al, 2004). Because KEL-8 contains a BTB domain, it might interact directly with CUL-3, the C. elegans Cullin 3 orthologue.…”
Section: Kel-8 Interacts With the Cul-3 Subunit Of Cullin 3 Ubiquitinmentioning
confidence: 99%
“…BTB domain proteins have recently been shown to function as substrate receptors for CDL3 ubiquitin ligases (Furukawa et al, 2003;Geyer et al, 2003;Pintard et al, 2003;Xu et al, 2003;Zhang et al, 2004). The BTB domain of this new class of substrate receptor (e.g., MEL-26) interacts with the Cullin repeats of Cul3, analogous to the manner by which Skp1 interacts with Cul1 in the CDL1/SCF complex.…”
Section: Kel-8 Is a Substrate Receptor For Cdl3mentioning
confidence: 99%
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“…VHL and SOCS proteins, via their additional protein-protein interaction modules, target various substrates differentially to the CUL2-ROC1 or CUL5-ROC2 catalytic cores (Kamura et al 1998(Kamura et al , 2001(Kamura et al , 2004Stebbins et al 1999;Zhang et al 1999). Omitting a linker, CUL3 utilizes its N-terminal domain to bind to proteins with a conserved 100-residue protein motif known as a BTB domain, which, via additional protein-protein interaction domains, then target various substrates to the CUL3-ROC1 catalytic core (Furukawa et al 2003;Geyer et al 2003;Pintard et al 2003;Xu et al 2003). The presence of multiple substrate receptors-mammals express >60 F-box, 40 SOCS, and 200 BTB proteins-suggests that cullins may form the largest family of E3 ligase complexes and control the ubiquitination of a wide variety of substrates.…”
mentioning
confidence: 99%
“…4). Thus, proteins of this group are found in lower eukaryotes, such as [29][30][31] . CUL-3 is an E2 ubiquitin conjugating enzyme.…”
Section: Btb/poz Domainsmentioning
confidence: 99%