Bu-Shen-Yi-Qi formula ameliorates airway remodeling in murine chronic asthma by modulating airway inflammation and oxidative stress in the lung

Cui, Jie; Xu, Fei; Tang, Zhao You; Wang, Wenqian; Hu, Ling; Yan, Chen‐Hua; Luo, Qingli; Gao, Hongjian; Wei, Ying; Dong, Jingcheng

doi:10.1016/j.biopha.2019.108694

Cited by 44 publications

(27 citation statements)

References 49 publications

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“…Thus, this study demonstrated that ses-trin2 might participate in airway remodeling in COPD. Airway remodeling is a recognized characteristic in the course of COPD [27], which is a complex structural change caused by multiple factors [16,28,29]. Our study demonstrated that there are typical pathological characteristics of airway remodeling in the airway tissues of COPD, including airway subepithelial fibrosis, reticular basement membrane fragmentation and cilia clutter.…”

Section: Discussionmentioning

confidence: 51%

Correlation between sestrin2 expression and airway remodeling in COPD

Zhang

Wei

et al. 2020

BMC Pulm Med

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Background Airway remodeling is a major pathological characteristic of chronic obstructive pulmonary disease (COPD), and has been shown to be associated with oxidative stress. Sestrin2 has recently drawn attention as an important antioxidant protein. However, the underlying correlation between sestrin2 and airway remodeling in COPD has yet to be clarified. Methods A total of 124 subjects were enrolled in this study, including 62 control subjects and 62 COPD patients. The pathological changes in airway tissues were assessed by different staining methods. The expression of sestrin2 and matrix metalloproteinase 9 (MMP9) in airway tissues was monitored by immunohistochemistry. Enzyme-linked immunosorbent assays (ELISAs) were used to detect the serum concentrations of sestrin2 and MMP9. The airway parameters on computed tomography (CT) from all participants were measured for evaluating airway remodeling. The relationship between serum sestrin2 and MMP9 concentration and airway parameters in chest CT was also analyzed. Results In patients with COPD, staining of airway structures showed distinct pathological changes of remodeling, including cilia cluttered, subepithelial fibrosis, and reticular basement membrane (Rbm) fragmentation. Compared with control subjects, the expression of sestrin2 and MMP9 was significantly increased in both human airway tissues and serum. Typical imaging characteristics of airway remodeling and increased airway parameters were also found by chest CT. Additionally, serum sestrin2 concentration was positively correlated with serum MMP9 concentration and airway parameters in chest CT. Conclusion Increased expression of sestrin2 is related to airway remodeling in COPD. We demonstrated for the first time that sestrin2 may be a novel biomarker for airway remodeling in patients with COPD.

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Section: Discussionmentioning

confidence: 51%

Correlation between sestrin2 expression and airway remodeling in COPD

Zhang

Wei

et al. 2020

BMC Pulm Med

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“…BSYQF has frequent application in clinical treatment of respiratory diseases such as asthma. Our previous research suggested that BSYQF exerted anti-inflammatory, anti-oxidant and anti-remodeling effects in asthma, and we identified sixteen main bioactive components including FMT ( Luo et al, 2014 ; Nurahmat et al., 2014 ; Cui et al., 2019 ). As previously demonstrated, FMT has therapeutic properties in hyperlipidemia and obesity ( Fu et al., 2019 ; Wang Y. et al., 2019 ), cancers ( Hu et al., 2019 ; Tay et al., 2019 ) and inflammatory diseases ( Li et al., 2018 ; Aladaileh et al., 2019 ; Luo et al., 2019 ; Wang X. S. et al., 2019 ).…”

Section: Discussionmentioning

confidence: 96%

Formononetin Attenuates Airway Inﬂammation and Oxidative Stress in Murine Allergic Asthma

et al. 2020

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Allergic asthma has been considered as a respiratory disorder with pathological features of airway inflammation and remodeling, which involves oxidative stress. Formononetin (FMT) is a bioactive isoflavone obtained from Chinese herb Radix Astragali, and has been reported to have notable anti-inflammatory and antioxidant effects in several diseases. The purpose of our study was to elaborate the effects of FMT on asthma and the underlying mechanisms. To establish allergic asthma model, BALB/c mice were given ovalbumin (OVA) sensitization and challenge, treated with FMT (10, 20, 40 mg/kg) or dexamethasone (2 mg/kg). The effects of FMT on lung inflammation and oxidative stress were assessed. In OVA-induced asthmatic mice, FMT treatments significantly ameliorated lung function, alleviated lung inflammation including infiltration of inflammatory cells, the elevated levels of interleukin (IL)-4, IL-5, and IL-13, immunoglobulin (Ig) E, CC motif chemokine ligand 5 (CCL5, also known as RANTES), CCL11 (also called Eotaxin-1), and IL-17A. In addition, FMT treatments eminently blunted goblet cell hyperplasia and collagen deposition, and remarkably reduced oxidative stress as displayed by decreased reactive oxygen species (ROS), and increased superoxide diamutase (SOD) activity. Furthermore, to clarify the potential mechanisms responsible for the effects, we determined the inflammation and oxidation-related signaling pathway including nuclear factor kappa b (NF-kB), c-Jun N-terminal kinase (JNK), and the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2). FMT treatments appeared to dramatically inhibit the activation of NF-kB and JNK, significantly elevated the expression of heme oxygenase 1 (HO-1) but failed to activate expression of Nrf2. In conclusion, our study suggested that FMT had the therapeutic effects in attenuating airway inflammation and oxidative stress in asthma.

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“…Airway remodeling is a recognized characteristic in the course of COPD (21), which is a complex structural change caused by multiple factors (15,22,23). Our study demonstrated that there are typical pathological characteristics of airway remodeling in the airway tissues of COPD, including airway subepithelial brosis, reticular basement membrane fragmentation and cilia clutter.…”

Section: Discussionmentioning

confidence: 52%

Sestrin2 Was Involved in Airway Remodeling in COPD: A Multi-level Research

Zhang¹,

Wei²,

Ji³

et al. 2020

Preprint

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Background. Airway remodeling is a major pathological characteristic of chronic obstructive pulmonary disease (COPD), which is greatly associated with oxidative stress. Sestrin2 has recently drawn attention as a representative antioxidant protein. However, the underlying correlation between sestrin2 and airway remodeling in COPD has not yet been clarified.Methods. A total of 124 subjects were enrolled in this study, including 62 control subjects and 62 COPD patients. The pathological changes in airway tissues were showed by different staining methods. The expression of sestrin2 and matrix metalloproteinase 9 (MMP9) in airway tissues was assessed by Immunohistochemistry staining. Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum concentrations of sestrin2 and MMP9. The airway parameters on computed tomography (CT) of all participants were measured for the evaluation of airway remodeling. Serum sestrin2 concentrations' relationship with MMP9 and airway parameters on chest CT was further analyzed. Results. In patients with COPD, staining results of airway structure showed noticeable pathological changes of remodeling, including cilia cluttered, subepithelial fibrosis, and reticular basement membrane (Rbm) fragmentation. Compared with control subjects, the expression of sestrin2 and MMP9 was significantly increased in both human airway tissues and serum. Typical imaging characteristics of airway remodeling and increased airway parameters were found on chest CT. Additionally, the serum sestrin2 concentration was positively correlated with serum MMP9 concentration and airway parameters on chest CT.Conclusion. Increased expression of sestrin2 is related to airway remodeling in COPD at three levels including histology, biomarkers and imaging. It is demonstrated for the first time that sestrin2 may be a novel biomarker for airway remodeling in COPD.

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Bu-Shen-Yi-Qi formula ameliorates airway remodeling in murine chronic asthma by modulating airway inflammation and oxidative stress in the lung

Cited by 44 publications

References 49 publications

Correlation between sestrin2 expression and airway remodeling in COPD

Correlation between sestrin2 expression and airway remodeling in COPD

Formononetin Attenuates Airway Inﬂammation and Oxidative Stress in Murine Allergic Asthma

Sestrin2 Was Involved in Airway Remodeling in COPD: A Multi-level Research

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