Buccal adhesive films with moisturizer- the next level for dry mouth syndrome?

Laffleur, Flavia; Krouská, Jitka; Tkácz, Jakub; Pekař, Miloslav; Aghai, Farid; Netsomboon, Kesinee

doi:10.1016/j.ijpharm.2018.08.032

Cited by 21 publications

(16 citation statements)

References 29 publications

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“…EC was also applied for the preparation of allantoin-loaded films for the management of dry mouth syndrome. The findings revealed that the produced films were functional, mucoadhesive, flexible, and stable, with the potential for treating various intraoral diseases [123]. EC-based mucoadhesive buccal films containing fluticasone formulated by solvent casting technique showed acceptable physicochemical properties, homogenous drug distribution, adequate mucoadhesion time, moderate swelling, and sustained drug release up to 12 h [124].…”

Section: Applicability Of Ec In Pharmaceutical Formulationsmentioning

confidence: 99%

Ethylcellulose–A Pharmaceutical Excipient with Multidirectional Application in Drug Dosage Forms Development

2019

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Polymers constitute the most important group of excipients utilized in modern pharmaceutical technology, playing an essential role in the development of drug dosage forms. Synthetic, semisynthetic, and natural polymeric materials offer opportunities to overcome different formulative challenges and to design novel dosage forms for controlled release or for site-specific drug delivery. They are extensively used to design therapeutic systems, modify drug release, or mask unpleasant drug taste. Cellulose derivatives are characterized by different physicochemical properties, such as swellability, viscosity, biodegradability, pH dependency, or mucoadhesion, which determine their use in industry. One cellulose derivative with widespread application is ethylcellulose. Ethylcellulose is used in pharmaceutical technology as a coating agent, flavoring fixative, binder, filler, film-former, drug carrier, or stabilizer. The aim of this article is to provide a broad overview of ethylcellulose utilization for pharmaceutical purposes, with particular emphasis on its multidirectional role in the development of oral and topical drug dosage forms.

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Section: Applicability Of Ec In Pharmaceutical Formulationsmentioning

confidence: 99%

Ethylcellulose–A Pharmaceutical Excipient with Multidirectional Application in Drug Dosage Forms Development

2019

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“…On the other hand, HPMC substitution types with lower contents of hydroxypropyl groups are characterized by high viscosity, mucoadhesion, stiffness, and mechanical resistance. Hence, mixtures of polymers with different degrees of substitution or their combination with other polymers, i.e., polyvinylpyrrolidone, polyvinyl alcohol, carbomer, gelatin, or chitosan, are often used to obtain a carrier with optimal properties [ 134 , 136 ].…”

Section: Carriers and Biodegradable Polymeric Materials In Dentistrymentioning

confidence: 99%

“…Additionally, in combination with mucoadhesive gels, films can remain on the mucosa for a longer period of time, which is also important when the formulation is applied to lesions located on the oral mucosa. Laffleur et al [ 136 ] used various semi-synthetic cellulose derivatives, i.e., ethylcellulose, hydroxyethylcellulose, hydroxypropyl methylcellulose, and carboxymethyl cellulose sodium salt with polyvinylpyrrolidone K30 or K90 and triethyl citrate as a plasticizer. Furthermore, they designed mucosal films with the above-mentioned derivatives for the targeted application of allantoin to the mucosa in patients suffering from dry mouth.…”

Section: Carriers and Biodegradable Polymeric Materials In Dentistrymentioning

confidence: 99%

Polymer-Based Carriers in Dental Local Healing—Review and Future Challenges

et al. 2021

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Polymers in drug formulation technology and the engineering of biomaterials for the treatment of oral diseases constitute a group of excipients that often possess additional properties in addition to their primary function, i.e., biological activity, sensitivity to stimuli, mucoadhesive properties, improved penetration of the active pharmaceutical ingredient (API) across biological barriers, and effects on wound healing or gingival and bone tissue regeneration. Through the use of multifunctional polymers, it has become possible to design carriers and materials tailored to the specific conditions and site of application, to deliver the active substance directly to the affected tissue, including intra-periodontal pocket delivery, and to release the active substance in a timed manner, allowing for the improvement of the form of application and further development of therapeutic strategies. The scope of this review is polymeric drug carriers and materials developed from selected multifunctional groups of natural, semi-synthetic, and synthetic polymers for topical therapeutic applications. Moreover, the characteristics of the topical application and the needs for the properties of carriers for topical administration of an active substance in the treatment of oral diseases are presented to more understand the difficulties associated with the design of optimal active substance carriers and materials for the treatment of lesions located in the oral cavity.

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“…The utilization of ethylcellulose polymers alone or in conjunction with other adjuvants in the preparation of useful film-like drug carriers is well documented in recent times (de Toledo et al, 2016, Laffleur et al, 2018, Scoutaris et al, 2018, Yildir et al, 2018, Zhang et al, 2019, Zhu et al, 2018). Amongst other drug delivery applications are their use in the construction of buccal films for delivery within the oral cavity.…”

Section: Macro-structured Delivery Systems Fabricated From Ethylcellumentioning

confidence: 99%

“…This was evidenced through a study reported by Laffleur and team where ethylcellulose 10 cP was applied in combination with other pharmaceutical additives for the preparation of robust allantoin-loaded films for the management of dry mouth syndrome has been demonstrated. The findings showed that the produced films were functional, mucoadhesive, flexible and stable with great promise for treating various intraoral cavity diseases (Laffleur et al, 2018). A related study reported ethylcellulose functioning as a backing sheet for bilayered mucoadhesive buccal films containing a combination of ornidazole and dexamethasone prepared for treating oral ulcers.…”

Section: Macro-structured Delivery Systems Fabricated From Ethylcellumentioning

confidence: 99%