Premium ethylcellulose polymer based architectures at work in drug delivery

Adeleke, Oluwatoyin A.

doi:10.1016/j.ijpx.2019.100023

Cited by 45 publications

(39 citation statements)

References 144 publications

(218 reference statements)

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“…Ethyl butanoate is used as a plasticizer along with some other short-and medium-chain esters to make ethylcellulose plastics, which are soft and flexible. 119…”

Section: As a Plasticizermentioning

confidence: 99%

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The occurrence, enzymatic production, and application of ethyl butanoate, an important flavor constituent

Minhazul

2020

Flavour & Fragrance J

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Fermented food is loved by people all over the world because of the unique flavor. Esters of short-chain fatty acids are renowned for their contribution to the flavor of different fermented foods. In these foods, esters are produced in a diverse proportion because of microbial activities. 1,2 It is often needed to add esters as flavor additives to maintain and enhance the flavor or add a special flavor tone. 3 The growing demand for specific flavor has been a major scientific research area to produce esters on a large scale and in a safe and cost-proficient way. Natural sources such as fruits are the primary origin of esters. Esters can be extracted from these natural sources using various techniques such as fractional distillation, compound extraction using supercritical fluids, continuous liquid-liquid extraction, pervaporation, and adsorption. 4,5 Plants contain esters in a very low amount and also depend on the plant growth and climatic conditions. 6 Therefore, direct extraction of esters from natural sources is costly, time-consuming, and lower in yield, and the quality is not up to the mark. 7-9 But the extracted esters are marked as natural and can be used for food production. 10

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“…Ethyl butanoate is used as a plasticizer along with some other short-and medium-chain esters to make ethylcellulose plastics, which are soft and flexible. 119…”

Section: As a Plasticizermentioning

confidence: 99%

“…It is mainly used as a thin‐film coating material for vitamins and medical pills, and as a thickening agent in cosmetics and different industrial processes. Ethyl butanoate is used as a plasticizer along with some other short‐ and medium‐chain esters to make ethylcellulose plastics, which are soft and flexible 119 …”

Section: Application Of Ethyl Butanoatementioning

confidence: 99%

The occurrence, enzymatic production, and application of ethyl butanoate, an important flavor constituent

Minhazul

2020

Flavour & Fragrance J

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“…Because of possible degradation of the PET substrates by acetone in the conventional graphene transfer process with poly(methyl methacrylate) (PMMA), ethyl cellulose (EC) was used as a supporting film and removed by ethanol. [58] EC, a bio-compatible material commonly used as a coating for medicinal pills and drug delivery systems, [59,60] left less residue than PMMA after the transfer, [61] making such EC transfer approach specifically suited to graphene bio-applications. Graphene transferred on PET substrate was characterized by Raman spectroscopy.…”

Section: Resultsmentioning

confidence: 99%

Hydrogenated Graphene Improves Neuronal Network Maturation and Excitatory Transmission

et al. 2021

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Traditional treatments for central nervous system disorders have shown limits and challenges. [1-3] Alternative ways to outperform current state-of-the-art technologies are required in neuroscience, especially for neuronal regeneration [4,5] and electrical sensing/recording. [6] Despite a lot of efforts have been made to develop implantable neuronal devices (e.g., electrodes for deep brain stimulation, [7] retinal implants, [8,9] peripheral nerve stimulators, [10] and intracranial electrodes for diagnostic purposes [11]), further research is needed to design an ideal neuronal interface embracing a combination of electrical conductivity and flexibility/lightness, together with high biocompatibility. Graphene has attracted considerable attention due to its outstanding properties, [12-17] such as high electrical and thermal conductivity, mechanical strength, ultra-thinness, and biocompatibility, opening new Graphene is regarded as a viable bio-interface for neuroscience due to its biocompatibility and electrical conductivity, which would contribute to efficient neuronal network signaling. Here, monolayer graphene grown via chemical vapor deposition is treated with remote hydrogen plasma to demonstrate that hydrogenated graphene (HGr) fosters improved cell-to-cell communication with respect to pristine graphene in primary cortical neurons. When transferred to polyethylene terephthalate, HGr exhibits higher wettability than graphene (water contact angle of 83.7° vs 40.7°), while preserving electrical conductivity (≈3 kΩ □-1). A rich and mature network is observed to develop onto HGr. The intrinsic excitability and firing properties of neurons plated onto HGr appears unaltered, while the basic passive and active membrane properties are fully preserved. The formation of excitatory synaptic connections increases in HGr with respect to pristine graphene, leading to a doubled miniature excitatory postsynaptic current frequency. This study supports the use of hydrogenation for tailoring graphene into an improved neuronal interface, indicating that wettability, more than electrical conductivity, is the key parameter to be controlled. The use of HGr can bring about a deeper understanding of neuronal behavior on artificial bio-interfaces and provide new insight for graphene-based biomedical applications.

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“…The surface morphology of the CPT microparticles was influenced by the amount of EC used, a hydrophobic polymer that is used for film coating or in polymeric matrices, in formulation. Batches manufactured with high EC content produced microparticles with smooth surfaces [55,56]. Conversely, batches produced with low EC content produced microparticles with rough, corrugated surfaces.…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

Formulation and Characterisation of a Combination Captopril and Hydrochlorothiazide Microparticulate Dosage Form

2020

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Cardiovascular diseases such as hypertension and cardiac failure in South African children and adolescents are effectively managed long term, using a combination treatment of captopril and hydrochlorothiazide. The majority of commercially available pharmaceutical products are designed for adult patients and require extemporaneous manipulation, prior to administration to paediatric patients. There is a need to develop an age appropriate microparticulate dosing technology that is easy to swallow, dose and alter doses whilst overcoming the pharmacokinetic challenges of short half-life and biphasic pharmacokinetic disposition exhibited by hydrochlorothiazide and captopril. An emulsion solvent evaporation approach using different combinations of polymers was used to manufacture captopril and hydrochlorothiazide microparticles. Design of experiments was used to develop and analyse experimental data, and identifyoptimum formulation and process conditions for the preparation of the microparticles. Characterisation studies to establish encapsulation efficiency, in vitro release, shape, size and morphology of the microparticles were undertaken. The microparticles produced were in the micrometre size range, with an encapsulation efficiency >75% for both hydrochlorothiazide and captopril. The microparticulate technology is able to offer potential resolution to the half-life mediated dosing frequency of captopril as sustained release of the molecule was observed over a 12-h period. The release of hydrochlorothiazide of >80% suggests an improvement in solubility limited dissolution.

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Premium ethylcellulose polymer based architectures at work in drug delivery

Abstract: Graphical abstract

Cited by 45 publications

References 144 publications

The occurrence, enzymatic production, and application of ethyl butanoate, an important flavor constituent

The occurrence, enzymatic production, and application of ethyl butanoate, an important flavor constituent

Hydrogenated Graphene Improves Neuronal Network Maturation and Excitatory Transmission

Formulation and Characterisation of a Combination Captopril and Hydrochlorothiazide Microparticulate Dosage Form

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