Buccal Film: A Novel Approach for Oral Mucosal Drug Delivery System

Haju, Shifa; Yadav, Sheela; BAIG, REESHA PARVEZ; Sawant, Gaurang

doi:10.22159/ajpcr.2021.v14i1.39687

Cited by 8 publications

(5 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The retention of the buccal film was observed after two minutes when the contents of the beaker were gently agitated to simulate the conditions of the buccal cavity. The time required for the film to detach from the mucosal surface was used to assess the mucoadhesion time [24].…”

Section: Ex-vivo Adhesion Timementioning

confidence: 99%

Formulation and Optimization of Mucoadhesive Buccal Film for Nicotine Replacement Therapy

Prakash¹,

SONI²,

PASWAN³

et al. 2023

Int J App Pharm

View full text Add to dashboard Cite

Objective: Nicotine replacement therapy (NRT) is a widely used method for reducing the desire to smoke and managing withdrawal symptoms during smoking cessation efforts. The research work aims to prepare and optimize a mucoadhesive nicotine buccal film by solvent casting method to provide the rapid onset and prolonged effects of cigarette smoking. Methods: Mucoadhesive nicotine buccal films were developed from the polymers Carbopol 934, Eudragit RLPO, and HPMC E15 by solvent casting method. The optimization of the mucoadhesive nicotine buccal film was performed using a three-factor, three-level Box-Behnken design where Carbopol 934, Eudragit RLPO, and HPMC E15 were selected as independent variables, while the swelling index, adhesion time, mucoadhesive strength, and cumulative % drug release were selected as response variables. Results: The optimized mucoadhesive nicotine buccal film showed uniform thickness and drug content. It had a swelling index of 188.21%, adhesion time of 7 h 45 min, and mucoadhesive strength of 0.23 N. The film showed a burst release followed by a steady release of 76.55 % over 360 min. It exhibited a 2-fold enhancement in buccal mucosal permeation as compared to a lozenge. Conclusion: The mucoadhesive nicotine buccal film prepared by the solvent casting method provides a rapid onset of action and prolonged effect for an extended period which replicates the effects of cigarette smoking. The findings show that it will reduce the frequency of administration, as a result of decreased nicotine cravings and reduced withdrawal symptoms, compared to currently available NRTs, ultimately helping individuals quit smoking.

show abstract

Section: Ex-vivo Adhesion Timementioning

confidence: 99%

Formulation and Optimization of Mucoadhesive Buccal Film for Nicotine Replacement Therapy

Prakash¹,

SONI²,

PASWAN³

et al. 2023

Int J App Pharm

View full text Add to dashboard Cite

show abstract

“… Improved interaction with the client [39].  Precise administration of the dosage  Increased safety and stability [40]  If there are any negative reactions, it is simple to remove from the administration site [34]  Gels and ointments for the buccal mucosa are semi-solid dosage forms that have the benefit of being simple to apply to the mucosa [41]…”

Section: Advantages Of Buccal Drug Deliverymentioning

confidence: 99%

Nanoparticles Loaded Mucoadhesive Buccal Patches - Review

Sabareesh¹,

Suma²,

Ravi³

et al. 2022

JPRI

View full text Add to dashboard Cite

Drug distribution for both local and systemic conditions is significantly facilitated by buccal methods of administration. When a rapid beginning of action is necessary, they have proven to be a potent substitute for the conventional oral route, the buccal route is regarded as patient-friendly. Although many procedures have been explored, drug permeability and regulated drug release via this route of delivery remain concerns for the effective therapy. They have shown to be an effective alternative to the traditional oral route, especially when fast onset of action is required. The buccal route is considered patient friendly due to its non-invasive nature and ease of administration. Nanotechnology has advanced to the point that clinical uses have been considered. The use of nanoparticles in buccal dosage forms not only provides efficient distribution but also lowers biological system side effects. Many methods for loading and delivering drug-loaded nanoparticles to the buccal mucosa have been proposed, both for topical and systemic administration. The primary objective of this review is to provide an overview of the nanotechnological methods that have been so far developed to enhance the buccal administration of medications.

show abstract

“…Additionally, MTX is chemically unstable; it quickly breaks down when exposed to extremes of pH or temperature, light, or both. These factors make it difficult to produce suitable oral dose formulations for medications like MTX, which are highly lipophilic and photo-unstable [2,3]. The limited bioavailability is the main obstacle to the development of different dosage formulations.…”

Section: Introductionmentioning

confidence: 99%

Improving Solubility of Methotrexate by Solid Dispersion

et al. 2023

View full text Add to dashboard Cite

Objective: Methotrexate (MTX) is a folate antimetabolite used for the management of neoplastic diseases like leukemia and breast cancer, Methotrexate is also used in the treatment of psoriasis as well as rheumatoid arthritis. The goal of this research was to improving the solubility and dissolution profile of methotrexate solid dispersion by using different polymers. Methods: A total six formulas were prepared as solid dispersion of methotrexate by solvent evaporation method by using polyethylene glycol (PEG-4000) and poly Vinyl pyrolidone (PVP-K30) as polymeric solubilizer in ratio (1:1,1:2,1:4), Then the solid dispersion of methotrexate were evaluated by solubility test, permeability test and FTIR study. Results: All six solid dispersion formulas showed a significant improvement in the solubility of methotrexate, and the formulations demonstrated improved in the rate of drug release of approximately 99.8±0.9 within 60 min. FTIR study for F3 and F6 show no drug-excipients interaction. Conclusion: Methotrexate was successfully enhanced its water solubility by using solid dispersion.

show abstract

Buccal Film: A Novel Approach for Oral Mucosal Drug Delivery System

Cited by 8 publications

References 49 publications

Formulation and Optimization of Mucoadhesive Buccal Film for Nicotine Replacement Therapy

Formulation and Optimization of Mucoadhesive Buccal Film for Nicotine Replacement Therapy

Nanoparticles Loaded Mucoadhesive Buccal Patches - Review

Improving Solubility of Methotrexate by Solid Dispersion

Contact Info

Product

Resources

About