Buccal films as a dressing for the treatment of aphthous lesions

Daněk, Zdeněk; Gajdziok, Jan; Doležel, Petr; Landová, Hana; Vetchý, David; Štembírek, Jan

doi:10.1111/jop.12563

Cited by 12 publications

(5 citation statements)

References 22 publications

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“…Management of aphthous lesions is mostly based on palliative treatment and depends on symptoms' severity. If the minor lesions appear occasionally, the treatment of choice is topical medicine including local anesthetics and non‐steroidal antiinflammatory agents, which help reducing the patient's discomfort (Daněk et al, 2017; Sanjana, Ahmed, & Bh, 2021). For more severe and frequent lesions, glucocorticoid steroids may have indication to reduce the ulcer size and shorten healing time (Liu et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

The efficacy of herbal medicine in the treatment of recurrent aphthous stomatitis: A systematic review of randomized clinical trials

Shavakhi

Sahebkar

Shirban

et al. 2021

Phytotherapy Research

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This systematic review was undertaken with the main aim of assessing the therapeutic effects of herbal medicines in recurrent aphthous stomatitis (RAS). A comprehensive search was performed in PubMed, Scopus, ISI Web of Science, and Google Scholar up to July 2021 to identify randomized clinical trials investigated the effects of herbal medicines on RAS. Thirty‐three papers comprising 2,113 patients met the eligibility criteria, of which 30 studies had a high quality based on the Jadad scale. Totally, 22 out of 30 studies which assessed the pain showed that herbal agents significantly decreased the pain compared with the control group or placebo. In 17 out of 25 studies that evaluated ulcer size, herbal agents significantly reduced the size of ulcers compared with the control or placebo groups. In 15 out of 18 studies that assessed the healing time, herbal agents significantly reduced healing time in the intervention groups compared with the placebo or control groups. Few adverse events were reported only in four studies. Findings of the current review indicated medicinal plants and phytochemicals as effective and safe agents that for the treatment of RAS.

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Section: Discussionmentioning

confidence: 99%

The efficacy of herbal medicine in the treatment of recurrent aphthous stomatitis: A systematic review of randomized clinical trials

Shavakhi

Sahebkar

Shirban

et al. 2021

Phytotherapy Research

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“…Herein, membrane-or film-like formulations would be a more adequate option to develop buccal carrier devices. Even so, these kinds of formulations are still an underrated domain, with very few alternatives successfully developed [13][14][15][16]. Among the natural substrates that can be used to engineer membranes or films, bacterial nanocellulose (BNC), viz.…”

Section: Introductionmentioning

confidence: 99%

Nanocellulose-Based Patches Loaded with Hyaluronic Acid and Diclofenac towards Aphthous Stomatitis Treatment

et al. 2020

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Nanostructured patches composed of bacterial nanocellulose (BNC), hyaluronic acid (HA) and diclofenac (DCF) were developed, envisioning the treatment of aphthous stomatitis. Freestanding patches were prepared via diffusion of aqueous solutions of HA and DCF, with different concentrations of DCF, into the wet BNC three-dimensional porous network. The resultant dual polysaccharides-based patches with a nanostructured morphology present thermal stability up to 200 °C, as well as good dynamic mechanical properties, with a storage modulus higher than 1.0 GPa. In addition, the patches are non-cytotoxic to human keratinocytes (HaCaT cells), with a cell viability of almost 100% after 24 h. The in vitro release profile of DCF from the patches was evaluated in simulated saliva, and the data refer to a diffusion- and swelling-controlled drug-release mechanism. The attained results hint at the possibility of using these dual polysaccharides-based oral mucosal patches to target aphthous stomatitis.

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“…Daněk et al [60] designed flexible films for use in aphthous lesions of the oral cavity. The clinical study was performed on 36 volunteers suffering from aphthous lesions.…”

Section: Thin Filmsmentioning

confidence: 99%

An overview of polymeric dosage forms in buccal drug delivery: State of art, design of formulations and their in vivo performance evaluation

Fonseca-Santos

2018

Materials Science and Engineering: C

109

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Owing to the ease of the administration, the oral cavity is an attractive site for the delivery of drugs. The main difficulty for administration via the buccal route is an effective physiological removal mechanism of the oral cavity that takes way the formulation from the buccal site and decreases the bioavailability of drugs. The use of mucoadhesive polymers in buccal drug delivery shows assessing buccal drug permeation and absorption, however some studies bring an in vivo performance. This review points to the use of polymers in the manufacture of drug delivery systems (hydrogels, films and tablets) and shows the results of their in vivo performance tests.

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Buccal films as a dressing for the treatment of aphthous lesions

Cited by 12 publications

References 22 publications

The efficacy of herbal medicine in the treatment of recurrent aphthous stomatitis: A systematic review of randomized clinical trials

The efficacy of herbal medicine in the treatment of recurrent aphthous stomatitis: A systematic review of randomized clinical trials

Nanocellulose-Based Patches Loaded with Hyaluronic Acid and Diclofenac towards Aphthous Stomatitis Treatment

An overview of polymeric dosage forms in buccal drug delivery: State of art, design of formulations and their in vivo performance evaluation

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