Buccoadhesive Tablets of Nifedipine: Standardization of A Novel Buccoadhesive-Erodible Carrier

Save, Tanuja; Venkitachalam, Padma

doi:10.3109/03639049409041964

Cited by 14 publications

(6 citation statements)

References 6 publications

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“…Recent years have seen an increasing interest in the development of novel buccal bioadhesive dosage forms. These are useful for both for systemic delivery of drugs, as well as for local targeting of drugs to a particular region in the body (8,9). A wide range of polymers of synthetic, semi synthetic and natural origin like carbopol, polycarbophil, sodium carboxymethylcellulose (SCMC), hydroxypropylmethylcellulose, chitosan and xanthan gum have been described for the formulation of bioadhesive systems but none of these polymer possess all the characteristics of an ideal polymer (nontoxic, nonirritant, strong non covalent adhesion, sustained release, stable and cheap) for a bioadhesive drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Buccal Bioadhesive Films Containing Clotrimazole

et al. 2008

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Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms. The aim of present study was to prepare and evaluate buccal bioadhesive films of clotrimazole for oral candidiasis. The film was designed to release the drug at a concentration above the minimum inhibitory concentration for a prolonged period of time so as to reduce the frequency of administration of the available conventional dosage forms. The different proportions of sodium carboxymethylcellulose and carbopol 974P (CP 974P) were used for the preparation of films. Carbopol was used to incorporate the desired bioadhesiveness in the films. The films were prepared by solvent casting method and evaluated for bioadhesion, in vitro drug release and effectiveness against Candida albicans. In vitro drug release from the film was determined using a modified Franz diffusion cell while bioadhesiveness was evaluated with a modified two-arm balance using rabbit intestinal mucosa as a model tissue. Films containing 5% CP 974P of the total polymer were found to be the best with moderate swelling along with favorable bioadhesion force, residence time and in vitro drug release. The microbiological studies revealed that drug released from the film could inhibit the growth of C. albicans for 6 h. The drug release mechanism was found to follow non-Fickian diffusion.

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Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Buccal Bioadhesive Films Containing Clotrimazole

et al. 2008

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“…7) These buccal bioadhesive films are useful for both for systemic delivery of drugs, as well as for local targeting of drugs to a particular region in the body. 6,8) A wide range of polymers of synthetic, semi synthetic and natural origin like Carbopol, Polycarbophil, sodium carboxymethylcellulose (SCMC), hydroxypropylmethylcellulose, chitosan and xanthan gum have been described for the formulation of bioadhesive systems but none of these polymer possess all the characteristics of an ideal polymer (nontoxic, nonirritant, strong non covalent adhesion, sustained release, stable and cheap) for a bioadhesive drug delivery system. 8) Carbopols are excellent bioadhesives but with potential mucosal irritating character.…”

mentioning

confidence: 99%

“…6,8) A wide range of polymers of synthetic, semi synthetic and natural origin like Carbopol, Polycarbophil, sodium carboxymethylcellulose (SCMC), hydroxypropylmethylcellulose, chitosan and xanthan gum have been described for the formulation of bioadhesive systems but none of these polymer possess all the characteristics of an ideal polymer (nontoxic, nonirritant, strong non covalent adhesion, sustained release, stable and cheap) for a bioadhesive drug delivery system. 8) Carbopols are excellent bioadhesives but with potential mucosal irritating character. 9) Irritant properties of Carbopols can be reduced by combining it with other non-irritant bioadhesive polymers like SCMC.…”

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confidence: 99%

In Vitro and in Vivo Evaluation of Buccal Bioadhesive Films Containing Salbutamol Sulphate

Singh

Soni

Rawat

et al. 2010

CHEMICAL & PHARMACEUTICAL BULLETIN

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The aim of present study was to prepare and evaluate buccal bioadhesive films of salbutamol sulphate (SS) for the treatment of asthma. The films were designed to release the drug for a prolonged period of time so as to reduce the frequency of administration of the available conventional dosage forms of SS. The different proportions of sodium carboxymethylcellulose (SCMC) and Carbopol 940P (CP 940P) were used for the preparation of films. Carbopol was used to incorporate the desired bioadhesiveness in the films. The films were prepared by solvent casting method and evaluated for bioadhesion, in vitro drug release and anti asthmatic effect (bronchoprotection) in histamine induced bronchospasm of guinea pigs. In vitro drug release from the film was determined using a modified Franz diffusion cell while bioadhesiveness was evaluated with a modified two-arm balance using guinea pig buccal mucosa as a model tissue. Films containing SCMC : CP 940P ratio of 76 : 24 was found to be the best with moderate swelling along with favorable bioadhesion force and in vitro drug release. The drug release mechanism was found to follow non-Fickian diffusion as release mechanism. The prolonged in vivo effect (bronchoprotection) obtained from the buccal bioadhesive film of SS administered via buccal route may improve the treatment of asthmatic disorders by reducing the frequency of administration which is associated with the tolerance effect of SS. Additionally for the clinical benefit, it is also expected to reduce the major adverse effects of SS such as tachycardia and arrhythmias via buccal absorption.Key words salbutamol sulphate; buccal bioadhesive film; Carbopol 940P; in vivo effect Chem. Pharm. Bull. 58(3) 307-311 (2010)

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“…Save et al [51] prepared and standardized a novel buccoadhesive erodible carrier consisting of sodium alginate, mannitol and PEG-6000 for the buccal delivery of nifedipine. They also formulated mucoadhesive buccal film of nifedipine consisting of sodium alginate, methyl cellulose (MC), polyvinyl pyrrolidone, mannitol, PEG6000 and glycerol.…”

Section: Studies On Calcium Channel Blockers Nifedipinementioning

confidence: 99%

Development of Transdermal and Transbuccal Drug Delivery Systems for Cardioactive Drugs with Special Reference to Anti- Hypertensive Agents

Agrawal

2003

Atherosclerosis, Hypertension and Diabetes

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The effeetiveness and better patient eompliance is driving a steady inerease in the use of transdermal patehes and bueeal films that deliver an array of drugs ranging from hormones to pain relievers and drugs acting on eardiovaseular system. Transdermal and transmueosal drug delivery systems are self eontained dosage forms which permit absorption of drug from the tissue surface, through its layers into the general eireulation, at controlled rates, resulting in sustained blood levels.Through a pateh plaeed on the skin, transdermal drug delivery ean be eustomized to deliver medieation up to seven days. These non-invasive, sustained release dosage forms can prevent the hepatie first pass metabolism of drugs and provide steady f10w of medication with the benefit of redueing adverse drug reaetions and leads to better patient compliance.In partieular, the simplieity and compliance aspects of patehes especially with the paediatric and geriatrie patients and also patients who cannot swallow the oral solid dosage forms and no longer want a daily eommitment in the administration of their medication will make them popular in the near future.The reason for the less popularity of these systems was due to the irritation caused because of sweating and decrease in the adhesion of the patches. However, these have been popular in elite countries because of the favourable temperature conditions there, with increasing facilities of controlling environmental conditions in most countries around the world, it is likely that these systems will gain further popularity in future.

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Buccoadhesive Tablets of Nifedipine: Standardization of A Novel Buccoadhesive-Erodible Carrier

Cited by 14 publications

References 6 publications

Preparation and Evaluation of Buccal Bioadhesive Films Containing Clotrimazole

Preparation and Evaluation of Buccal Bioadhesive Films Containing Clotrimazole

In Vitro and in Vivo Evaluation of Buccal Bioadhesive Films Containing Salbutamol Sulphate

Development of Transdermal and Transbuccal Drug Delivery Systems for Cardioactive Drugs with Special Reference to Anti- Hypertensive Agents

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