The authors have developed and applied a methodology to ewiluate and prioritize proposed waste minimization activities affecting Department of Energy (DOE) programs. This approach provides a systematic and defensible method for selecting a set ot" waste minimization proposals that maximizes the benefits to DOE while maintaining costs within a specified budget. The report discusses the development of a structured set of evaluation criteria to characterize waste minimization issues; techniques for documenting the anticipated and potential costs, risks, and benefits of waste minimization proposals; and a method of translating disparate data into a figure of merit for each proposal. A test case demonstration of this prioritization approach was applied t,: proposals currently being considered at two DOE weapons production facilities. Recommendations are provided t'c_r combining this approach with the existing DOE proposal selection process.