Buerger's disease associated with IgA nephropathy: report of two cases

Thromboangiitis obliterans (Buerger's disease)--a type of vasculitis in young, mostly male subjects--remains strangely linked to smoking, which determines its occurrence, progression and prognosis by currently unknown mechanisms. It affects the small and medium-sized arteries and veins of the limbs. Despite the usual absence of systemic signs and symptoms, initially intermittent arthritis, even if not observed in all cases, confer on this disease the status of a systemic vasculitis. Diagnosis requires the elimination of many other diseases. The severity of the disease lies in the need for amputation in more than a quarter of all patients. Complete cessation of smoking remains the cornerstone of therapy. Local care is the second essential element of treatment. Prostacycline analogues can be used to help the patient through critical ischaemia. Blockade with antagonists of cannabinoid or endothelin receptors and the use of gene- or cell-based therapy to induce therapeutic angiogenesis have opened up new possibilities for treatment.

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“…In addition to vascular problems, cases of nephropathy due to mesangial IgA deposition have been reported [64].…”

Section: Systemic Signs and Symptomsmentioning

confidence: 99%

Thromboangiitis obliterans or Buerger's disease: challenges for the rheumatologist

Puéchal¹,

Fiessinger

2006

Rheumatology

107

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“…A diagnosis of IgA nephropathy, also known as Buerger disease, was previously reported in a patient with TAO. 6 , 7 Circulating antibodies to collagen that are present in the blood of some patients with Buerger disease may cause an increase in cellular sensitivity to human Type I or Type III collagen or both. Renal impairment occurred in our patient during the most recent episode of CLTI.…”

Section: Discussionmentioning

confidence: 99%

Low-intensity pulsed ultrasound for ‘no-option’ chronic/critical limb-threatening ischaemia in a patient with Buerger disease: a case report

Mohamad Yusoff,

Kajikawa,

Sakamoto

et al. 2024

European Heart Journal - Case Reports

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Background Buerger disease, also known as Winiwarter-Buerger disease or thromboangiitis obliterans (TAO), is a non-specific inflammation of small and medium-sized arteries with thrombus obliteration and without atherosclerotic changes. Patients with TAO can develop chronic limb-threatening ischemia (CLTI) and are at risk of limb amputation despite smoking cessation and exercise therapy recommendations. Case summary A 72-year-old Japanese man presented with painful discoloration of toes and renal impairment. He was diagnosed with Rutherford-Classification stage 6 CLTI with IgA nephropathy. He refused limb amputation. Clinical symptoms improved after treatment with low-intensity pulsed ultrasound (LIPUS). LIPUS is a noninvasive option to improve peripheral arterial disease symptoms. Despite the conventional therapy measures, there was worsening of the limbs condition. The noninvasive investigational treatment option of LIPUS was initiated after the poor clinical outcomes of the conventional therapy measures. The patient’s symptoms in the bilateral lower limbs, ulcers and the blue-colored toes gradually recovered. After one year of treatment with LIPUS, he had achieved better walking independence with improved quality of life. Conclusion LIPUS is a noninvasive option for therapeutic angiogenesis with the potential to improve ischemic limb conditions in patients with peripheral arterial disease and to avoid major amputation.

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“…IgA nephropathy has been observed with various diseases (Emancipator et al, 1985), including hepatobiliary disorders, regional enteritis, coeliac disease, Sjogren's syndrome, monoclonal IgA gammopathy, dermatitis herpetiformis, Henoch-Shonlein purpura, ankylosing spondylitis, and most recently Buerger's disease (Remy et al, 1988). Computerized search of the medical literature has not revealed any reported case to-date of sensorineural deafness associated with IgA nephropathy.…”

Section: Discussionmentioning

confidence: 99%

Sensorineural deafness associated with IgA nephropathy

Ataya

1989

J. Laryngol. Otol.

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IgA nephropathy is an immune complex glomerulonephritis in which examination of the renal biopsy by immu-nofluorescence reveals IgA as the predominant antibody deposited in the glomerular mesangium (Clarkson et al., 1984). It was first described by Berger in 1969. The disease is more common in males and occurs generally during the second or third decades of life (Emancipator et al., 1985). A case of established IgA nephropathy with subsequent onset of sensorineural deafness is described.

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Buerger's disease associated with IgA nephropathy: report of two cases

Cited by 8 publications

References 9 publications

Thromboangiitis obliterans or Buerger's disease: challenges for the rheumatologist

Thromboangiitis obliterans or Buerger's disease: challenges for the rheumatologist

Low-intensity pulsed ultrasound for ‘no-option’ chronic/critical limb-threatening ischaemia in a patient with Buerger disease: a case report

Sensorineural deafness associated with IgA nephropathy

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