Bulky DNA Adducts in Cord Blood, Maternal Fruit-and-Vegetable Consumption, and Birth Weight in a European Mother–Child Study (NewGeneris)

Pedersen, Marie; Schoket, Bernadette; Godschalk, Roger; Wright, John; Stedingk, Hans von; Törnqvist, Margareta; Sunyer, Jordi; Nielsen, Jeanette K.; Merlo, Domenico Franco; Mendez, Michelle A.; Meltzer, Helle Margrete; Lukács, Viktória; Landström, Anette; Kyrtopoulos, Soterios A.; Kovács, Katalin; Knudsen, Lisbeth E.; Haugen, Margaretha; Hardie, Laura J.; Gützkow, Kristine B.; Fleming, Sarah; Fthenou, Eleni; Farmer, Peter B.; Espinosa, Aina; Chatzi, Leda; Brunborg, Gunnar; Brady, Nigel J.; Botsivali, Maria; Arab, Khelifa; Anna, Lívia; Alexander, Jan; Agramunt, Sílvia; Kleinjans, Jos; Segerbäck, Dan; Kogevinas, Manolis

doi:10.1289/ehp.1206333

Cited by 36 publications

(31 citation statements)

References 43 publications

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“…Evidence from experimental studies demonstrate that benzo[a]pyrene (BaP) crosses the placenta (19) and has been classified by the U.S. Environmental Protection Agency (EPA) as a probable human carcinogen. Furthermore, animal studies have indicated PAHs may influence gestational length and intrauterine growth (20) and human studies have associated urinary and blood biomarkers of exposures to PAHs with birth weight (21) and gestational length (22). …”

Section: Introductionmentioning

confidence: 99%

Exposure to airborne polycyclic aromatic hydrocarbons during pregnancy and risk of preterm birth

Padula

Noth

Hammond

et al. 2014

Environmental Research

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Background Preterm birth is an important marker of health and has a prevalence of 12-13% in the U.S. Polycyclic aromatic hydrocarbons (PAHs) are a group of organic contaminants that form during the incomplete combustion of hydrocarbons, such as coal, diesel and gasoline. Studies suggest that exposure to PAHs during pregnancy is related to adverse birth outcomes. The aim of this study is to evaluate the association between exposure to PAHs during the pregnancy and preterm birth. Methods The study population included births from years 2001-2006 of women whose maternal residence was within 20 km of the primary monitoring site in Fresno, California. Data in the Fresno area were used to form a spatio-temporal model to assign daily exposure to PAHs with 4, 5, or 6 rings at the maternal residence throughout pregnancy of all of the births in the study area. Gestational age at birth and relevant covariates were extracted from the birth certificate. Results We found an association between PAHs during the last 6 weeks of pregnancy and birth at 20-27 weeks (OR=2.74; 95% CI: 2.24-3.34) comparing the highest quartile to the lower three. The association was consistent when each quartile was compared to the lowest (OR2nd=1.49, 95% CI: 1.08-2.06; OR3rd=2.63, 95% CI:1.93-3.59; OR4th=3.94, 95% CI:3.03-5.12). Inverse associations were also observed for exposure to PAHs during the entire pregnancy and the first trimester and birth at 28-31 weeks and 20-27 weeks. Conclusion An association between PAH exposure during the 6 weeks before delivery and early preterm birth was observed. However, the inverse association with early preterm birth offers an unclear, and potentially complex, inference of these associations.

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Section: Introductionmentioning

confidence: 99%

Exposure to airborne polycyclic aromatic hydrocarbons during pregnancy and risk of preterm birth

Padula

Noth

Hammond

et al. 2014

Environmental Research

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“…20 Biomarkers of exposure to PAHs (n=612) were associated with lower birth weight only in newborns from Norway, Denmark, and England. 21 In addition, birth weight was lower in infants in the medium and high thirds of dioxin and dioxin-like PCB levels in cord blood (n=967) compared with those in the lowest third. 12 Furthermore, gestational age was shorter by about half a week in the highest compared with the lowest exposure levels; this association seemed to be stronger for boys than for girls.…”

Section: Are There Other Effects On Health?mentioning

confidence: 89%

Fetal exposure to dietary carcinogens and risk of childhood cancer: what the NewGeneris project tells us: Table 1

Kleinjans

Botsivali

Kogevinas

et al. 2015

BMJ

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“…The coordination in Denmark was selected from the experiences with mother-child cohorts and adverse effects of air pollution (18,19). The Czech partners were leading in human biomonitoring and air pollution (20)(21)(22) as well as socioecomomic research on health risks benefits (23)(24)(25)(26) and consumer behavior (27).…”

Section: Newdanubementioning

confidence: 99%

Perinatal health in the Danube region – new birth cohort justified

Knudsen

Andersen

Šrám³

et al. 2017

Reviews on Environmental Health

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Abstract In 2013–2015, a consortium of European scientists – NEWDANUBE – was established to prepare a birth cohort in the Danube region, including most of the countries with the highest air pollution in Europe, the area being one-fifth of the European Union’s (EU’s) territory, including 14 countries (nine EU member states), over 100 million inhabitants, with numerous challenges: big socioeconomic disparities, and a region-specific environmental pollution. The consortium reflects the EU Strategy for the Danube Region Strategy (2010), which identified 11 thematic Priority Areas – one of which is the environmental risks. Birth cohorts have been established in all other areas of Europe and collaborative efforts in promoting maternal and fetal health by minimizing the environmental exposures have been initiated with national, European, and international financial support. A birth cohort in the Danube area could apply the established methodologies for prenatal exposure and birth outcome measurements and establish a platform for targeted health promotion in couples planning pregnancies. The consortium included a strong socioeconomic part focusing on the participant’s active registration of exposures to environmental toxicants and health indicators of disease and wellbeing, combined with investigation of their risk-reducing behavior and interventions to change their lifestyle to avoid the adverse health risks. Willingness to pay for reducing the health risks in children is also proposed to be estimated. Further collaboration and networking is encouraged as the Danube region has several decades of experience and expertise in biomonitoring adult populations exposed environmentally or occupationally. Additionally, some countries in the Danube region launched small-scale birth cohorts encouraged by participation in several ongoing research projects.

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Bulky DNA Adducts in Cord Blood, Maternal Fruit-and-Vegetable Consumption, and Birth Weight in a European Mother–Child Study (NewGeneris)

Cited by 36 publications

References 43 publications

Exposure to airborne polycyclic aromatic hydrocarbons during pregnancy and risk of preterm birth

Exposure to airborne polycyclic aromatic hydrocarbons during pregnancy and risk of preterm birth

Fetal exposure to dietary carcinogens and risk of childhood cancer: what the NewGeneris project tells us: Table 1

Perinatal health in the Danube region – new birth cohort justified

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