Bullfrog oil (Rana catesbeiana Shaw) induces apoptosis, in A2058 human melanoma cells by mitochondrial dysfunction triggered by oxidative stress

Amaral-Machado, Lucas; Oliveira, Wógenes N.; Alencar, Éverton do Nascimento; Cruz, Ana Katarina Menezes da; Rocha, Hugo Alexandre Oliveira; Ebeid, Kareem; Salem, Aliasger K.; Egito, Eryvaldo Sócrates Tabosa do

doi:10.1016/j.biopha.2019.109103

Cited by 11 publications

(9 citation statements)

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“…6 fatty acids, in addition to cholesterol 9. 5 and ethyl-iso allocholate 3.5 6,9,10 . However, despite its broad popular use, especially against inflammatory conditions, there is a lack of scientific evidence supporting such therapeutic property.…”

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confidence: 99%

“…To date, a limited number of studies have shown scientific evidence of the BFO potential for the development of pharmaceutical products, as showed by previous reports from our research group in which promising antimicrobial and antibiofilm activities were investigated 7,11 . In addition, the cytotoxic activity of BFO not only in natura, but also carried out by nanostructured systems against melanoma cells was also elucidated 6,9 . Nevertheless, no report was found in the literature to support its anti-inflammatory activity, specially the evaluation of the inflammatory pathways involved in this process.…”

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confidence: 99%

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Bullfrog Oil Reduces the Carrageenan-induced Edema in Wistar Rats by <i>in vitro</i> Reduction of Inflammatory Mediators

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confidence: 99%

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Bullfrog Oil Reduces the Carrageenan-induced Edema in Wistar Rats by <i>in vitro</i> Reduction of Inflammatory Mediators

et al. 2020

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“…However, it did not specify how this liposomal system can trigger the apoptosis process in the A549 cells. Indeed, this cell death process is complex and can be triggered by several phenomena, such as (i) oxidative stress, which leads to mitochondrial dysfunction; (ii) caspase-activation; (iii) intracellular signaling pathway, which leads to apoptosis induction; or even by (iv) mitochondrial damage, which facilitates the cytochrome C release to cytosol, leading to apoptosis [ 35 ].…”

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confidence: 99%

Ferri–Liposomes: Preformulation and Selective Cytotoxicity against A549 Lung Cancer Cells

et al. 2021

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Liposomes have become successful nanostructured systems used in clinical practices. These vesicles are able to carry important drug loadings with noteworthy stability. The aim of this work was to develop iron oxide-loaded stealth liposomes as a prospective alternative for the treatment of lung cancer. In this study, citric acid iron oxide nanoparticles (IONPs-Ac) were synthesized and encapsulated in stealth liposomes. Their cytotoxicity and selectivity against lung tumor cells were assessed. Stealth liposomal vesicles, with relevant content of IONPs-Ac, named ferri–liposomes (SL-IONPs-Ac), were produced with an average size of 200 nm. They displayed important cytotoxicity in a human lung cancer cells model (A549 cells), even at low concentrations, whereas free IONPs-Ac displayed adequate biocompatibility. Nevertheless, the treatment at the same concentration of ferri–liposomes against HEK-293 cells, a normal human cell lineage, was not significantly cytotoxic, revealing a probable lung tumor selectiveness of the fabricated formulation. Furthermore, from the flow cytometry studies, it was possible to infer that ferri–liposomes were able to induce A549 tumor cells death through apoptosis/ferroptosis processes, evidenced by a significant reduction of the mitochondrial membrane potential.

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“…With the deepening of research, it is believed that more natural products that can regulate the mitochondria have the potential to be used in treating diseases, which is of utmost importance. Oxidative Medicine and Cellular Longevity [44] Oxidative stress Bulbine frutescens [37] Bullfrog oil [38] Orientin [40] Asparanin A [42] Gracillin [44] Apoptosis Bulbine frutescens [37] Orientin [40] Licochalcone A [41] Asparanin A [42] Parameritannin A-2 [43] Cernumidine [45] Mitochondrial membrane potential imbalance Bullfrog oil [38] Rhein [39] Asparanin A [42] Cernumidine [45] Neurodegenerative diseases…”

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confidence: 99%

Remedying the Mitochondria to Cure Human Diseases by Natural Products

Shi

et al. 2020

Oxidative Medicine and Cellular Longevity

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Mitochondria are the ‘engine’ of cells. Mitochondrial dysfunction is an important mechanism in many human diseases. Many natural products could remedy the mitochondria to alleviate mitochondria-involved diseases. In this review, we summarized the current knowledge of the relationship between the mitochondria and human diseases and the regulation of natural products to the mitochondria. We proposed that the development of mitochondrial regulators/nutrients from natural products to remedy mitochondrial dysfunction represents an attractive strategy for a mitochondria-involved disorder therapy. Moreover, investigating the mitochondrial regulation of natural products can potentiate the in-depth comprehension of the mechanism of action of natural products.

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Bullfrog oil (Rana catesbeiana Shaw) induces apoptosis, in A2058 human melanoma cells by mitochondrial dysfunction triggered by oxidative stress

Cited by 11 publications

References 46 publications

Bullfrog Oil Reduces the Carrageenan-induced Edema in Wistar Rats by <i>in vitro</i> Reduction of Inflammatory Mediators

Bullfrog Oil Reduces the Carrageenan-induced Edema in Wistar Rats by <i>in vitro</i> Reduction of Inflammatory Mediators

Ferri–Liposomes: Preformulation and Selective Cytotoxicity against A549 Lung Cancer Cells

Remedying the Mitochondria to Cure Human Diseases by Natural Products

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