Bumetanide blocks the acquisition of conditioned fear in adult rats

Ko, Meng Chang; Lee, Ming Chung; Tang, Tso Hao; Amstislavskaya, Tamara G.; Tikhonova, Maria A.; Yang, Yi; Lu, Kwok Tung

doi:10.1111/bph.14125

Cited by 4 publications

(1 citation statement)

References 53 publications

(78 reference statements)

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“…Growing evidence suggests that addictive drugs, stress, and aversive stimuli alter Cl − homeostasis not only in the VTA, but also in the NAc, hippocampus, amygdala, and along the HPA axis [82–85]. Accordingly, human and animal studies implicate Cl − transporter dysfunction in a variety of neuropsychiatric disorders, including anxiety, depression, and substance use disorders [66, 86–88].…”

Section: Postsynaptic Inhibitory Plasticitymentioning

confidence: 99%

Inhibitory Plasticity of Mesocorticolimbic Circuits in Addiction and Mental Illness

Ostroumov¹,

Dani²

2018

Trends in Neurosciences

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Behavioral adaptations occur through remodeling of brain circuits, as arising, for instance, from experience-dependent synaptic plasticity. Drugs of abuse and aversive stimuli, such as stress, act on the mesocorticolimbic system, dysregulating adaptive mechanisms and leading to a variety of aberrant behaviors associated with neuropsychiatric disorders. Until recently, research in the field has commonly focused on experience-dependent synaptic plasticity at excitatory synapses. However, there is growing evidence that synaptic plasticity within inhibitory circuits is an important contributor to maladaptive behaviors. We speculate that restoring normal inhibitory synaptic transmission is a promising therapeutic target for correcting some of the circuit abnormalities underlying neuropsychiatric disorders.

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