Large eddy simulations of large-scale CH 4 fire plumes (1.59-2.61 MW) with two different CFD packages, FireFOAM and FDS, are presented. It is investigated how the vorticity generation mechanism and puffing behavior of largescale fire plumes differs from previously studied iso-thermal buoyant plumes of the same scale. In addition, the predictive capabilities of the turbulence and combustion models, currently used by the two CFD codes, to accurately capture the fire dynamics and the buoyancy-generated turbulence associated with large-scale fire plumes are evaluated. Results obtained with the two CFD codes, typically used for numerical simulations of fire safety applications, are also compared with respect to the average and rms velocities and temperatures, puffing frequencies, average flame heights and entrainment rates using experimental data and well-known correlations in literature. Furthermore, the importance of the applied reaction time scale model in combination with the Eddy Dissipation Model is examined. In particular, the influence of the considered mixing time scales in the predicted centerline temperatures is illustrated and used to explain the discrepancies between the two codes.