Burden and Pattern of Cancer in the Sudan, 2000-2006

Mohammed, Moawia Elbalal; Hassan, A.M. El; Abdel-Hadi, Hani; Elsadig, Moawia; Adam, D.; Elmamoun, K.; Hamid, Rosdiana Abdul; Elias, H.; Abdallah, Mohammed O.E; Abdelkarim, Z. B.; Elwali, Nasr Eldin; Mohammed, Sulma I.

doi:10.9734/bjmmr/2014/6863

Cited by 10 publications

(7 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Globocan, about two million new cases were diagnosed in the United States in 2018 with expected deaths of 626,679 [ 3 ]. BC incidence increases in North Sudan tribes, with 16.3% in Galyean, 6.6% in Shygea, and 5.3% in Danagala [ 4 ]. Women living in rural areas in Sudan constituted 58% of individuals presented with BC than those in urban areas [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus, gene mutation and estrogen and progesterone receptors in breast cancer: a cross-sectional study

Elagali¹,

Suliman²,

Altayeb³

et al. 2021

Pan Afr Med J

View full text Add to dashboard Cite

Introduction recent studies show a good relationship between breast cancer (BC) and human papillomaviruses (HPV) wich is responsible for about 18% of BC cases. This study aimed to assess the relationship between different genotypes of HPV and the expression of P53 and retinoblastoma (RB) genes and estrogen and progesterone receptors in BC among Sudanese women. Methods one hundred and fifty tissue blocks were obtained from females diagnosed with BC. Positive samples were used to determine genotypes with an applied biosystem (ABI 3730XL) genetic analyzer for sequencing and immunohistochemistry. Results 13/150 samples showed HPV DNA. High-risk HPV-16 was detected in 5 cases, high-risk-HPV-58 was found in four cases, and HPV-18 was detected in three cases. Low-risk-HPV-11 was detected in a single invasive lobular carcinoma (ILC) case. P53 and RB gene mutations were detected in 35 and 30 BC cases, respectively. P53 gene mutation was frequently identified in grade (III) BC while RB gene mutation was positive in grade (II). Grade (II) BC had a higher incidence of HPV-16 and 58. On the other hand, HPV-18 had a higher incidence in grade (III). Estrogen and progesterone receptors were expressed in 94 and 79 HPV cases among the study group, respectively. Conclusion this study elucidates the associations between HPV genotypes and BC. A statistically significant association was observed among p53 and RB gene mutations and different BC histological types. On the other hand, there was a statistically insignificant association between HPV genotyping and different BC gradings, BC histological types, P53 and RB genes mutations, and estrogen and progesterone receptor expression. Also, there was a statistically insignificant association among estrogen and progesterone receptors expression and BC grading. RB gene mutation was significantly associated with different BC grades. On the other hand, there was a statistically insignificant association between progesterone receptor expression and BC.

show abstract

Section: Introductionmentioning

confidence: 99%

Human papillomavirus, gene mutation and estrogen and progesterone receptors in breast cancer: a cross-sectional study

Elagali¹,

Suliman²,

Altayeb³

et al. 2021

Pan Afr Med J

View full text Add to dashboard Cite

show abstract

“…The incidence rate of ovarian cancer in the entire Sudan has yet to be identified; however, in a hospital-based data set from the National Cancer Institute, Gezira University, Central Sudan and Radiation Isotopes Center in Khartoum, collected between 2000 and 2006, ovarian cancer accounted for 6.8% (949) of all recorded cancers (n=226,652), and it was ranked the sixth most common cancer for both genders (3). Additionally, in a more recent data set (2009)(2010)) from the National Cancer Registry for Khartoum State alone, ovarian cancer was the fourth most common cancer in women, with an estimated incidence rate of 188 per 100,000 population, a gender-specific rate of 8.0 per 100,000 population, and an age-standardized rate (ASR) of 7.0 per 100,000 population (4).…”

Section: Introductionmentioning

confidence: 99%

Incidence and survival rates of ovarian cancer in low-income women in Sudan

Abuidris

Weng

Elhaj

et al. 2016

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. Ovarian cancer is the second most common gynecological cancer worldwide. Little is known about the disease in Sudan. The objective of the present study was to evaluate the incidence rate, age and stage at diagnosis, and median survival time of patients presenting at the National Cancer Institute-University of Gezira (NCI-UG), Sudan. Data were collected in a prospective study of women with ovarian cancer over a period of eleven years of follow-up (between 2000 and 2011). Descriptive statistics were used to summarize the distribution of the demographics of the sample. The direct method was used to compute the age-standardized rate (ASR) using data from the 1966 and 2000 World Standard Populations (WSPs). The Kaplan-Meier method was used to estimate survival functions and the median survival time. Log-rank tests were used to statistically compare between the survival functions. There were steady increases in ovarian cancer incidence rates between 2000 and 2009, with a slight decline noted in 2010 and 2011. The patients' age range was 9-90. The age-specific incidence rate increased greatly in women aged 55 years or older. The majority of the patients had stage III or IV disease. The annual ASR using WSPs 1966 and 2000 as standard populations were 3.3 and 3.7 per 100,000 women, respectively. The median survival time was 31 months (95% confidence interval, 19-43). The 5-year cumulative survival rate was 38%. In Sudan, ovarian cancer affects postmenopausal women, akin to what is reported in the developed world with high incidence rates. Presenting with advanced stage disease is the predominant factor that results in a short survival time for women.

show abstract

“…The most important benefits are that FNA is a simple, safe and cost-effective first-line method to investigate thyroid lesions, particularly in low-resource settings such as Sudan, in which most of the patients suffering from thyroid lesions presented late to the clinics due to their low-income status. Furthermore, the diagnosis of benign lesions is 50-fold that of malignant ones; this can be interpreted as an increase in the community awareness about thyroid diseases as well as more clinicians recognizing the utility of FNA in evaluating thyroid nodule 57,58 . However, further studies considering this increase in benign lesions showed be well investigated in respect to all factors associated with developing benign thyroid lesions.…”

Section: Discussionmentioning

confidence: 99%

Cytomorphological patterns of thyroid lesions among 1646 Sudanese patients: what we can learn from fine needle aspiration cytology retrospective analysis?

et al. 2020

View full text Add to dashboard Cite

Introduction: Fine-needle aspiration (FNA) cytology biopsy of the thyroid gland is an accurate and useful diagnostic tool in the initial evaluation of nodular thyroid lesions. We aimed in this study to determine the cytomorphological patterns of thyroid lesions diagnosed by FNA among Sudanese patients. Methods: A descriptive retrospective, clinic-based study was performed. Cytopathological records of patients that attended the Total Lab Care Clinic in Khartoum-Sudan between January 2016 and December 2017 were reviewed. Results: A total of 1646 patients records were reviewed; 1385 (84.1%) were females and 261 (15.9%) males. A total of 1563 (94.9%) were negative for malignancy, 39 (2.4%) were positive for malignancy, 42 (2.6%) were indeterminate for malignancy and 2 (0.1%) were non-diagnostic. Colloid goiter was seen in 1147 patients (73.4%), benign hemorrhagic cysts were seen in 257, Hashimoto thyroiditis was seen in 77, benign thyroid nodules were seen in 76, keratocysts were seen in 2, thyroglossal duct cysts were seen in 2, thyroid follicular adenoma was seen in 1 and myxedema was seen in 1. For malignant patients; 11 had anaplastic thyroid cancer, 8 had papillary thyroid cancer, 7 had follicular thyroid cancer, 5 had metastatic thyroid cancer, 4 had medullary thyroid cancer, 3 had non-Hodgkin lymphoma and 1 had thyroid follicular adenoma. For those indeterminate for malignancy, 24 had follicular neoplasm and 18 had Hurthle cell neoplasm. Conclusions: Fine needle aspiration cytology for thyroid nodules provides a rapid and non-invasive technique for the evaluation and differentiation between benign and malignant lesions. This study also addresses the increased predominance of benign thyroid lesions among young patients and thyroid malignancy among the 4th decade of life.

show abstract

Burden and Pattern of Cancer in the Sudan, 2000-2006

Cited by 10 publications

References 14 publications

Human papillomavirus, gene mutation and estrogen and progesterone receptors in breast cancer: a cross-sectional study

Human papillomavirus, gene mutation and estrogen and progesterone receptors in breast cancer: a cross-sectional study

Incidence and survival rates of ovarian cancer in low-income women in Sudan

Cytomorphological patterns of thyroid lesions among 1646 Sudanese patients: what we can learn from fine needle aspiration cytology retrospective analysis?

Contact Info

Product

Resources

About