Burden of atopic disease in Black and Hispanic patients with alopecia areata: a case–control study in the <i>All of Us</i> research program

Joshi, Tejas P; Fernandez, Briana; Friske, Sarah; Garcia, Danielle; Gedeon, Francesca; Gonzalez, Clarissa; Hanania, Hannah L.; Hinson, Darien; Holla, Swathi; Iacobucci, Alexander; Okundia, Fyona; Stafford, Haleigh; Strouphauer, Emily; Terrell, Maci; Tomaras, Miranda; Zhu, Harrison; Duvic, Madeleine

doi:10.1111/ijd.16528

Cited by 3 publications

(4 citation statements)

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“…Although we demonstrated higher socioeconomic status (higher SDI) was associated with a higher risk of AA at the gross national level, possibly driven by an increased burden of metabolic and autoimmune disease, 51,52 the pattern could be different at subnational ethnic level. Although not thoroughly analysed in this GBD report, the prevalence of AA is known to be affected by ethnicity 53,54 . Previous studies have demonstrated a higher risk of AA in African Americans 54 and Asians 55 compared to Whites in the US and the United Kingdom, respectively.…”

Section: Discussionmentioning

confidence: 92%

“…Although not thoroughly analysed in this GBD report, the prevalence of AA is known to be affected by ethnicity. 53,54 Previous studies have demonstrated a higher risk of AA in African Americans 54 and Asians 55 compared to Whites in the US and the United Kingdom, respectively. A complex interplay between hereditary elements and environmental influences might contribute to disparities in AA risk across ethnic groups.…”

Section: Discussionmentioning

confidence: 99%

“…When inspecting GBD super regions, there were considerable variations (Figure 5). Such a heterogeneous pattern may be stemmed from subnational and ethnic diversity; Blacks with AA have been shown to bear a greater burden of atopic disease compared to their White counterpart, possibly attributable to their limited access to healthcare and increased levels of stress due to socio‐economic factors 53 . Furthermore, regional‐level factors (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Such a heterogeneous pattern may be stemmed from subnational and ethnic diversity; Blacks with AA have been shown to bear a greater burden of atopic disease compared to their White counterpart, possibly attributable to their limited access to healthcare and increased levels of stress due to socio-economic factors. 53 Furthermore, regional-level factors (i.e. climate, culture, politics and healthcare system performances) may have further diversified the regional pattern, yet our data are limited to accurately exploring the underlying causes of such differences, and future studies should be followed to extend our understanding.…”

Section: F I G U R Ementioning

confidence: 99%

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Global, regional and national burden of alopecia areata and its associated diseases, 1990–2019: A systematic analysis of the Global Burden of Disease Study 2019

Jang

Park

Kim

et al. 2023

Eur J Clin Investigation

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Background No study to date has concomitantly reported the global burden of alopecia areata (AA) and its associated diseases. Methods The crude and age‐standardized rates of prevalence (ASPR), incidence (ASIR) and years lived with disability (YLDs) of AA were extracted from the global burden of disease, injuries and risk factors study (GBD) database between 1990 and 2019 for 204 countries and territories. We stratified the analysis by global region, nation, sex, age and sociodemographic index (SDI) to dissect the epidemiology of AA and its associated diseases. Results Alopecia areata was responsible for 0.024% of the total DALYs. Age‐standardized DALYs rate of AA was 7.51 [4.73–11.14] per 100,000. Overall ASPR, ASIR and age‐standardized YLDs rates were stable from 1990 to 2019 globally. All three rates were about two times higher in females compared to males and had a bimodal distribution with peaks at age 30–34 years and 60–64 years. AA burden was positively correlated with SDI (r = .375, p < .001) and was most prevalent in high‐income countries, especially North America. Countries with a high AA incidence were more likely to have high incidences of autoimmune diseases and low incidences of ischaemic heart disease and ischaemic stroke. Conclusions The burden of AA was prominent in females, young adults, high sociodemographic countries and North Americans. The study corroborates sex‐ and region‐specific implications and public health measures for AA and its associated burdens. These epidemiological data on AA burden can guide future research efforts, prevention strategies and allocation of resources.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

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Global, regional and national burden of alopecia areata and its associated diseases, 1990–2019: A systematic analysis of the Global Burden of Disease Study 2019

Jang

Park

Kim

et al. 2023

Eur J Clin Investigation

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Epidemiology of alopecia areata in the Hispanic/Latinx community: A cross-sectional analysis of the All of Us database

Joshi

Garcia

Gedeon

et al. 2023

Journal of the American Academy of Dermatology

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Updates on disorders in curly hair

Geisler,

Taye,

Larrondo

et al. 2024

Int J Dermatology

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Hair disorders, including central centrifugal cicatricial alopecia (CCCA), traction alopecia (TA), and acquired trichorrhexis nodosa (ATN), commonly occur in individuals with curly textured hair. Curly textured hair in individuals of African descent has unique properties and can present diagnostic and therapeutic challenges. CCCA has been linked to uterine leiomyoma and type 2 diabetes mellitus, as well as fibroproliferation. TA often presents with a fringe sign and can arise from high‐tension hairstyles presumed to be protective. Trichoscopy is useful in establishing a diagnosis; perifollicular halos are more commonly seen than perifollicular erythema or scale in CCCA. In TA, miniaturized follicles, hair casts, and “flambeau sign” can be seen. Hairstyling practices likely contribute to TA and ATN; however, the data are mixed on the role of chemical relaxers and heat styling in CCCA. Unique considerations in the presentation of frontal fibrosing alopecia in curly textured hair have also been published recently. This review provides a comprehensive, up‐to‐date summary of these disorders with an emphasis on their unique properties, as well as considerations in hair care for curly textured hair.

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Burden of atopic disease in Black and Hispanic patients with alopecia areata: a case–control study in the All of Us research program

Abstract: The first case of isolated facial cutanenous leishmaniasis in a Down syndrome infant: a case report and review of the literature.

Cited by 3 publications

References 5 publications

Global, regional and national burden of alopecia areata and its associated diseases, 1990–2019: A systematic analysis of the Global Burden of Disease Study 2019

Global, regional and national burden of alopecia areata and its associated diseases, 1990–2019: A systematic analysis of the Global Burden of Disease Study 2019

Epidemiology of alopecia areata in the Hispanic/Latinx community: A cross-sectional analysis of the All of Us database

Updates on disorders in curly hair

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