Burden of atrial fibrillation in India

Bohra, Vijay; Sharma, Gautam; Juneja, Rajnish

doi:10.4103/2395-5414.177228

Cited by 6 publications

(8 citation statements)

References 2 publications

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“…The data on epidemiological trends of AF from India are limited. 1 , 2 , 8 , 9 Though non-valvular AF is the commonest cause in the western population, in Indian settings, rheumatic heart disease still contributes to at least for half of the AF cases. In the western population, its prevalence is around 1–2% of the general population, occurring in up to 5% of people aged 75 or more.…”

Section: Discussionmentioning

confidence: 99%

“…Atrial fibrillation (AF) is the most common form of sustained arrhythmia in the world, and it is a major cause of stroke, apart from being symptomatic and sometimes leading to tachycardia-induced cardiomyopathy. When compared with the western population, Indians develop AF a decade earlier, 1 , 2 and hence, the impact of the disease is very significant.…”

Section: Introductionmentioning

confidence: 99%

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Intermediate term outcome after electrogram guided segmental ostial pulmonary vein isolation using an 8 mm tip catheter for paroxysmal atrial fibrillation

Pawar¹,

Vadivelu²,

Bachani³

et al. 2019

Indian Heart Journal

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Introduction Pulmonary vein isolation (PVI) is the most widely used procedure for ablation in patients with paroxysmal atrial fibrillation (AF). Not withstanding recent advancements in this field, including sophisticated three-dimensional (3D) based imaging and advanced ablation catheters with contact force technology, many patients and healthcare systems in developing countries will not afford such an expensive therapeutic procedure. There are no data from India analyzing the efficacy of PVI for PAF using conventional mapping and ablation. In this article, we have summarized the intermediate term outcome following PVI in patients with PAF using electrogram-based mapping and a 8 mm tip ablation catheter. Method A total of 42 consecutive patients who underwent PVI for symptomatic PAF not controlled with at least one antiarrhythmic drug were studied in a tertiary care institute from March 2011 to June 2018. Patients with rheumatic AF were excluded. The pulmonary vein (PV) anatomy was assessed by pulmonary angiography during the ablation procedure. Using conventional electrophysiologic mapping, a variable curve Lasso catheter placed in the PVs was used to guide the earliest site of breakthrough. The segmental ostial PVI was performed using a 8 mm tip radiofrequency (RF) ablation catheter. Elimination of all PV ostial potentials and complete entrance block into the PV were considered indicative of complete electrical isolation. Follow-up visits were scheduled at one, three, and six months after the procedure, and every six months thereafter. History, symptom review, clinical examination, and 12-lead ECG were performed at each follow-up. Results At pre-discharge, 34 patients (81%) were in sinus rhythm, while eight patients (19%) continued to have atrial fibrillation. The age of the study population was 51.5 ± 11.7 yrs. The mean follow-up duration was 44 ± 21 months (range 6–84 months). The number of PVs isolated included one (five patients, 11.9%), two (20 patients, 47.6%), three (12 patients, 28.6%), and four (five patients, 11.9%). In 42 patients, a total of 101 PVs were isolated. The right superior PV (RSPV) was isolated in 37 patients, the left superior PV (LSPV) was isolated in 39 patients, the left inferior PV (LIPV) was isolated in 14 patients, and the right inferior PV (RIPV) was isolated in six patients. The procedure duration was 125 ± 29 min and the fluoroscopy time was 47 ± 13 min. The number of patients who remained in sinus rhythm at 1, 6, 12, and 24 months were 34 (81%), 32 (76%), 30 (71%), and 26 (62%), respectively. Two patients of these underwent repeat PVI, which was successful, and they had freedom from AF episodes. Complications were rare. One patient had a minor pericardial effusion, and one patient had transient sinus pauses, which were conservatively managed. Conclusion Conventional RF ablation using PV potential-based mapping and ablation with 8 mm tip catheters is safe for patients with PA...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intermediate term outcome after electrogram guided segmental ostial pulmonary vein isolation using an 8 mm tip catheter for paroxysmal atrial fibrillation

Pawar¹,

Vadivelu²,

Bachani³

et al. 2019

Indian Heart Journal

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“…The prevalence is estimated to be ≥1%, in adult population all over the world . In case of Indian population, the prevalence of AF is still not investigated in the general population; few studies suggested that rheumatic heart disease patients have a higher risk of AF . The Previous researcher has demonstrated AF as a multifactorial disorder that is regulated by genetic as well as nongenetic factors .…”

Section: Introductionmentioning

confidence: 99%

“…not investigated in the general population; few studies suggested that rheumatic heart disease patients have a higher risk of AF. 3 The Previous researcher has demonstrated AF as a multifactorial disorder that is regulated by genetic as well as nongenetic factors. 4 Although several risk factors for post-OP AF have been elucidated in few studies, but the mechanism of post-OP AF development still need to be elucidated.…”

mentioning

confidence: 99%

IL‐10(‐592A/C) gene variant a predictor of postoperative atrial fibrillation in the north Indian population

Yadav

Akhtar

Agarwal

et al. 2018

Journal of Arrhythmia

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BackgroundThere is an accumulating body of evidence indicating a strong association between inflammation and the pathogenesis of atrial fibrillation (AF) in different ethnicities across the globe. AF increases the risk of stroke and heart failure. Despite various researches on IL‐10 response, there is limited clinical evidence present, which demonstrate a role of these immunity regulators in AF. Therefore, this study was designed to decipher the role of IL‐10(‐592A/C) polymorphism in the development of postoperative AF (post‐OP AF).MethodThe study was designed for north Indian patients. The study included 90 patients with AF and 126 controls in sinus rhythm undergoing surgery at Department of Cardiovascular and thoracic surgery, SGPGIMS, Lucknow, India. DNA samples were genotyped for common single nucleotide polymorphism (SNP) in gene IL‐10(‐592A/C). The PCR‐based RFLP technique was used to assess the genotype frequencies. The multivariable logistic regression analysis was performed to study the association of other risk factors with AF.ResultsThe distribution of IL‐10(‐592A/C) genotypes (CC, AC, and AA) was found to be 48.41%, 47.61%, and 3.98% in controls and 41.11%, 45.55%, and 13.34% in cases, respectively (P = .0385). The frequency of allele A in cases was significantly higher than the control group (36.11% vs 27.77%, P = .0654). Compared with CC, AA genotype had increased risk of AF in both unadjusted and adjusted analyses.ConclusionsThis study suggests that IL‐10(‐592A/C) polymorphism may have significant association with post‐OP AF development in north Indian patients.

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“…[ 8 ] In India, the reported burden of AF is largely from few studies. [ 9 10 11 ] About 8% of stroke patients had AF in Trivandrum population-based registry. However, they did not collect information on valvular heart disease.…”

Section: Introductionmentioning

confidence: 99%

Clinical features, risk factors, and short-term outcome of ischemic stroke, in patients with atrial fibrillation: Data from a population-based study

Akanksha

Kaur

Singh

et al. 2017

Ann Indian Acad Neurol

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Burden of atrial fibrillation in India

Cited by 6 publications

References 2 publications

Intermediate term outcome after electrogram guided segmental ostial pulmonary vein isolation using an 8 mm tip catheter for paroxysmal atrial fibrillation

Intermediate term outcome after electrogram guided segmental ostial pulmonary vein isolation using an 8 mm tip catheter for paroxysmal atrial fibrillation

IL‐10(‐592A/C) gene variant a predictor of postoperative atrial fibrillation in the north Indian population

Clinical features, risk factors, and short-term outcome of ischemic stroke, in patients with atrial fibrillation: Data from a population-based study

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