IL‐10(‐592A/C) gene variant a predictor of postoperative atrial fibrillation in the north Indian population

Abstract

BackgroundThere is an accumulating body of evidence indicating a strong association between inflammation and the pathogenesis of atrial fibrillation (AF) in different ethnicities across the globe. AF increases the risk of stroke and heart failure. Despite various researches on IL‐10 response, there is limited clinical evidence present, which demonstrate a role of these immunity regulators in AF. Therefore, this study was designed to decipher the role of IL‐10(‐592A/C) polymorphism in the development of postoperative AF (post‐OP AF).MethodThe study was designed for north Indian patients. The study included 90 patients with AF and 126 controls in sinus rhythm undergoing surgery at Department of Cardiovascular and thoracic surgery, SGPGIMS, Lucknow, India. DNA samples were genotyped for common single nucleotide polymorphism (SNP) in gene IL‐10(‐592A/C). The PCR‐based RFLP technique was used to assess the genotype frequencies. The multivariable logistic regression analysis was performed to study the association of other risk factors with AF.ResultsThe distribution of IL‐10(‐592A/C) genotypes (CC, AC, and AA) was found to be 48.41%, 47.61%, and 3.98% in controls and 41.11%, 45.55%, and 13.34% in cases, respectively (P = .0385). The frequency of allele A in cases was significantly higher than the control group (36.11% vs 27.77%, P = .0654). Compared with CC, AA genotype had increased risk of AF in both unadjusted and adjusted analyses.ConclusionsThis study suggests that IL‐10(‐592A/C) polymorphism may have significant association with post‐OP AF development in north Indian patients.

Elevated Peripheral T Helper Cells Are Associated With Atrial Fibrillation in Patients With Rheumatoid Arthritis

“…Meanwhile, IL-10 produced by Treg cells is a potent anti-inflammatory cytokine (33). A recent study has suggested that IL-10(-592A/C) polymorphism may have a prominent association with postoperative AF (35). Therefore, we reasonably speculate that the increase of Th1/ Treg may associate with the development of RA-AF.…”

Inactivation of the NLRP3 inflammasome mediates exosome-based prevention of atrial fibrillation

“…Interestingly, the early cytokine changes observed in atrial tissue after treatment with EVs included several pro-inflammatory cytokines known to play a role in the progression of postoperative AF (IL-6, MCP-1, and TGFβ1) [48,49]. Notably, unlike another type of heart-derived cell [50], EDC EVs had no effect on the cardiac content of IL-10, which has been demonstrated to inhibit the development of AF [51][52][53].…”