Burden of colorectal cancer in China, 1990−2017: Findings from the Global Burden of Disease Study 2017

Abstract

Objective Our goal is to analyze the trend of colorectal cancer (CRC) regarding the death, incidence and prevalence rates over time, and to provide epidemiological knowledge basis for health policy revision by comparing data about fatal outcomes of CRC in 2017 to those data in 1990, which was extracted from the Global Burden of Disease (GBD). Methods The time trend and changes of CRC burden from 1990 to 2017 were measured by using the methods and results from the Institute for Health Metrics and Evaluation (IHME) GBD 2017, based on the rates of death, incidence and prevalence. Results The death rate of CRC is 13.24/100,000, accounting for 1.79% of total deaths in China in 2017. In 1990, CRC ranked 21st in all causes of death in China compared to its 11th ranking in 2017. The death, incidence and prevalence rate of CRC were standardized by the age scale of the global population in 2010, the change of standardized death rate of CRC was not significant, from 9.33/100,000 in 1990 to 10.10/100,000 in 2017. The standardized incidence rate of CRC significantly increased from 12.18/100,000 in 1990 to 22.42/100,000 in 2017. The standardized prevalence rate of CRC significantly increased from 44.55/100,000 in 1990 to 118.40/100,000 in 2017. The trend of the prevalence rate in both genders grow higher in 2017 compared to the 1990, resulting in 141.6%, 209.8% and 189.0% for the studied three age groups (15−49, 50−69 and 70+ years old), respectively. The death rate increased in the age groups of 50−69 and 70+ years in both genders (8.6% and 31.0% respectively), in contrast to a decrease of death rate in the age group of 15−49 years old (−10.8%). Conclusions China experienced a stunning increase in terms of incidence and prevalence rate of CRC from 1990 to 2017. To decrease the burden of CRC, prevention and management of known risk factors should be promoted through national polices.

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“…2 The increasing burden of CRC and related mortality highlight the need for early detection and prevention. 3 Many factors are involved in the pathogenesis of CRC, including intestinal flora disorder, abnormal immune response, as well as genetic, environmental and lifestyle risk factors such as obesity, alcohol consumption, smoking, poor diet, and lack of exercise. Intestinal inflammation is one of the most important factors leading to CRC and is associated with dysregulation of numerous signaling pathways.…”

“… 2 The increasing burden of CRC and related mortality highlight the need for early detection and prevention. 3 …”

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“…Despite lower rates compared with the world average (incidence, 17.81/100,000 persons; mortality, 8.12/100,000 persons) ( 3 , 4 ), China has the highest number of CRC new cases and CRC-related deaths in the world because of its relatively large population ( 5 ). Moreover, the country faces a tough challenge of increasing CRC cases related to a westernized lifestyle, which threatens the health of individuals and incurs a heavy social and economic burden ( 6 , 7 ).…”

Long non‑coding RNA ATB is associated with metastases and promotes cell invasion in colorectal cancer via sponging miR‑141‑3p

“…As CRC remains prevalent in China ( 36 ), identifying the molecular mechanism underlying CRC development and progression is an important clinical challenge. lncRNAs have gained increased research attention worldwide ( 37 , 38 ), and there is increasing evidence that lncRNAs are related to cancer development and progression ( 39 , 40 ).…”