Epidemiology and risk factors of colorectal cancer in China

Yang, Yong; Han, Zihan; Li, Xin; Huang, An; Shi, Jingyi; Gu, Jin

doi:10.21147/j.issn.1000-9604.2020.06.06

Cited by 84 publications

(70 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CRC has been the second most common cause of cancer death, even including 17,930 cases and 3,640 deaths in patients under 50 years of age ( 1 ). In China, the incidence and mortality of CRC have been on the rise ( 2 ) and CRC incurs a heavy economic burden on the society and individuals ( 3 ). Moreover, patients with colitis-associated cancer (CAC), a particular type of CRC that develops from inflammatory bowel diseases (IBDs), have an earlier morbidity and a poorer prognosis ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Landscape of cell heterogeneity and evolutionary trajectory in ulcerative colitis-associated colon cancer revealed by single-cell RNA sequencing

Wang

Zhu

Zhang

et al. 2021

Chinese Journal of Cancer Research

View full text Add to dashboard Cite

Objective The goal of this study was to get preliminary insight on the intra-tumor heterogeneity in colitis-associated cancer (CAC) and to reveal a potential evolutionary trajectory from ulcerative colitis (UC) to CAC at the single-cell level. Methods Fresh samples of tumor tissues and adjacent UC tissues from a CAC patient with pT3N1M0 stage cancer were examined by single-cell RNA sequencing (scRNA-seq). Data from The Cancer Genome Atlas (TCGA) and The Human Protein Atlas were used to confirm the different expression levels in normal and tumor tissues and to determine their relationships with patient prognosis. Results Ultimately, 4,777 single-cell transcriptomes (1,220 genes per cell) were examined, of which 2,250 (47%) and 2,527 (53%) originated from tumor and adjacent UC tissues, respectively. We defined the composition of cancer-associated stromal cells and identified six cell clusters, including myeloid, T and B cells, fibroblasts, endothelial and epithelial cells. Notable pathways and transcription factors involved in these cell clusters were analyzed and described. Moreover, the precise cellular composition and developmental trajectory from UC to UC-associated colon cancer were graphed, and it was predicted that CD74 , CLCA1 , and DPEP1 played a potential role in disease progression. Conclusions scRNA-seq technology revealed intra-tumor cell heterogeneity in UC-associated colon cancer, and might provide a promising direction to identify novel potential therapeutic targets in the evolution from UC to CAC.

show abstract

Section: Introductionmentioning

confidence: 99%

Landscape of cell heterogeneity and evolutionary trajectory in ulcerative colitis-associated colon cancer revealed by single-cell RNA sequencing

Wang

Zhu

Zhang

et al. 2021

Chinese Journal of Cancer Research

View full text Add to dashboard Cite

show abstract

“…However, previous epidemiological studies related to CRC mortality over time across China were either of limited scope in premature mortality patterns or failed to provide adequate analysis of drivers of CRC mortality change over time. [ 1 , 6 , 7 ] Accordingly, explicit evaluation of data from national mortality surveillance is needed to appropriately guide efforts to potentially fill remaining knowledge gaps.…”

Section: Introductionmentioning

confidence: 99%

Mortality and years of life lost of colorectal cancer in China, 2005–2020: findings from the national mortality surveillance system

Wang

Yin

Liu

et al. 2021

Chinese Medical Journal

View full text Add to dashboard Cite

Background: Colorectal cancer (CRC) is the fourth cause of cancer death in China. We aimed to provide national and subnational estimates and changes of CRC premature mortality burden during 2005–2020. Methods: Data from multi-source on the basis of the national surveillance mortality system were used to estimate mortality and years of life lost (YLL) of CRC in the Chinese population during 2005–2020. Estimates were generated and compared for 31 provincial-level administrative divisions in China. Results: Estimated CRC deaths increased from 111.41 thousand in 2005 to 178.02 thousand in 2020; age-standardized mortality rate decreased from 10.01 per 100,000 in 2005 to 9.68 per 100,000 in 2020. Substantial reduction in CRC premature mortality burden, as measured by age-standardized YLL rate, was observed with a reduction of 10.20% nationwide. Marked differences were observed in the geographical patterns of provincial units, and they appeared to be obvious in areas with higher economic development. Population aging was the dominant driver which contributed to the increase in CRC deaths, followed by population growth and age-specific mortality change. Conclusions: Substantial discrepancies were observed in the premature mortality burden of CRC across China. Targeted considerations were needed to promote a healthy lifestyle, expand cost-effective CRC early screening and diagnosis, and improve medical treatment to reduce CRC mortality among high-risk populations and regions with inadequate healthcare resources.

show abstract

“…In 2020, there were nearly 1.9 million new CRC cases (10%), and almost 0.9 million CRC patients died (9.4%) (1). The incidence of and mortality from CRC in China are lower compared with the world average (incidence rate: 1,781 per 100,000 people; mortality rate: 8.12 per 100,000 people), but the number of new CRC cases and CRC-related deaths in China is the highest in the world (2).…”

Section: Introductionmentioning

confidence: 99%

Solanaceous Vegetables and Colorectal Cancer Risk: A Hospital-Based Matched Case-Control Study in Northeast China

Liu

Jiang

et al. 2021

Front. Nutr.

View full text Add to dashboard Cite

Background: Dietary factors are regarded as an essential influence in changing colorectal cancer (CRC) risk. However, there is no clear conclusion of the relationship between solanaceous vegetables and colorectal cancer at present. The study aimed to evaluate the intake of solanaceous vegetables in relation to colorectal cancer risk among the Northeast Chinese population.Methods: We carried out a hospital-based case-control study in three hospitals in Northeast China from 2009 to 2011. The study finally included 833 patients with CRC and 833 controls matched separately according to age, gender, and city of residence. We applied a structural questionnaire to collect demographic characteristics and dietary information by face-to-face interview and adopted conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Stratified analyses were conducted by sex and subsites.Results: There was no obvious correlation between total intake of solanaceous plants and CRC risk. The adjusted OR for the highest quartile and the lowest quartile was 1 (95% CI: 0.68–1.5). Certain types of solanaceous vegetables were negatively associated with the risk of CRC, such as eggplant (OR = 0.42; 95% CI:0.29–0.62) and sweet pepper (OR = 0.48; 95%CI: 0.33–0.7). Potato was found to have a positive correlation with CRC (OR = 1.76; 95% CI: 1.26–2.47). In the stratified analyses by gender, total solanaceous vegetables intake was inversely associated with CRC risk only in men. In the stratified analyses of cancer subsites, no significant association between total solanaceous vegetables intake and CRC risk was found.Conclusion: No findings showed that the intake of total solanaceous vegetables was related to the reduction of CRC risk. However, specific types of solanaceous vegetables indicated an inverse association with CRC risk.

show abstract

Epidemiology and risk factors of colorectal cancer in China

Cited by 84 publications

References 98 publications

Landscape of cell heterogeneity and evolutionary trajectory in ulcerative colitis-associated colon cancer revealed by single-cell RNA sequencing

Landscape of cell heterogeneity and evolutionary trajectory in ulcerative colitis-associated colon cancer revealed by single-cell RNA sequencing

Mortality and years of life lost of colorectal cancer in China, 2005–2020: findings from the national mortality surveillance system

Solanaceous Vegetables and Colorectal Cancer Risk: A Hospital-Based Matched Case-Control Study in Northeast China

Contact Info

Product

Resources

About