Burden of disease and economic impact of human Streptococcus suis infection in Viet Nam

Abstract

Background Streptococcus suis is a zoonotic disease mainly affecting men of working age and can result in death or long-term sequelae, including severe hearing loss and vestibular dysfunction. We aimed to quantify the burden of disease and economic impact of this infection in Viet Nam. Methods The annual disease incidence for the period 2011–2014 was estimated based on surveillance data using a multiple imputation approach. We calculated disease burden in disability-adjusted life years (DALYs) and economic costs using an incidence-based approach from a patient’s perspective and including direct and indirect impacts of S. suis infection and its long-term sequelae. Results The estimated annual incidence rate was 0.318, 0.324, 0.255 and 0.249 cases per 100 000 population in 2011, 2012, 2013 and 2014, respectively. The corresponding DALYs lost were 1832, 1866, 1467 and 1437. The mean direct cost per episode was US$1635 (95% confidence interval 1352–1923). The annual direct cost was US$370 000–500 000 and the indirect cost was US$2.27–2.88 million in this time period. Conclusions This study showed a large disease burden and high economic impact of S. suis infection and provides important data for disease monitoring and control.

Burden of disease and productivity impact of Streptococcus suis infection in Thailand

“…The highest prevalence of S . suis infection is in South East Asia, notably Thailand (0.487 per 100,000) [ 3 ] and Vietnam (0.249 per 100,000) [ 4 ]. Globally, there are more than 1,600 reported cases [ 1 ].…”

“…In this study, the burden of disease was quantified in term of disability-adjusted life years (DALYs). The DALYs lost ranged 1,437–1,866 from 2011–2014 with the mean direct cost per episode of US$1,635 (95%CI 1,352–1,923) reflecting a significant economic impact [ 4 ]. However, long-term consequences including cardiac complication after infective endocarditis (IE) and follow-up audiological testing were not captured in the model.…”

“…SNHL is the most common complication among S.suis meningitis patients which is typically bilateral and permanent [1,2]. The highest prevalence of S.suis infection is in South East Asia, notably Thailand (0.487 per 100,000) [3] and Vietnam (0.249 per 100,000) [4]. Globally, there are more than 1,600 reported cases [1].…”

“…S.suis infection has been recognised as the cause of substantial loss in swine industry [6]. The only previous study on economic burden from S.suis infection in human was conducted in Vietnam [4]. In this study, the burden of disease was quantified in term of disabilityadjusted life years (DALYs).…”

Inactivation of the htpsA gene affects capsule development and pathogenicity of Streptococcus suis

“…Among all serotypes, S. suis 2 is the most virulent and frequently isolated serotype from clinically diseased piglets [6,7]. During the last 20 years, sporadic or large outbreaks of human S. suis 2 infections have occurred occasionally worldwide [8,9]. In 1998 and 2005, two outbreaks of S. suis 2 in China caused severe streptococcal toxic shock-like syndrome in infected patients with mortalities as high as 62.7% to 81.3% [10].…”