Burden of Disease Caused by Otitis Media: Systematic Review and Global Estimates

Monasta, Lorenzo; Ronfani, Luca; Marchetti, Federico; Montico, Marcella; Brumatti, Liza Vecchi; Bavcar, Alessandro; Grasso, Domenico Leonardo; Barbiero, Chiara; Tamburlini, Giorgio

doi:10.1371/journal.pone.0036226

Cited by 852 publications

(807 citation statements)

References 41 publications

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“…A study by Sideris and Glattke [28] found that children younger than four years were often unable to perform pure tone screening, suggesting that pure tone audiometry requires a higher level of cognitive maturity. Additionally, the incidence of acute otitis media and otitis media with effusion is high in LMICs, with a higher incidence in children between the ages of two and five years, thus adding to a higher referral rate [30–32]. …”

Section: Discussionmentioning

confidence: 99%

Community-based hearing screening for young children using an mHealth service-delivery model

Hussein

Swanepoel

Mahomed

et al. 2018

Global Health Action

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Background: Hearing loss is one of the most common developmental disorders identifiable at birth with its prevalence increasing throughout school years. However, early detection programs are mostly unavailable in low- and middle-income countries (LMICs) where more than 80% of children with hearing loss reside.Objective: This study investigated the feasibility of a smartphone-based hearing screening program for preschool children operated by community healthcare workers (CHWs) in community-based early childhood development (ECD) centers.Method: Five CHWs were trained to map ECD centers and conduct smartphone-based hearing screenings within a poor community in South Africa over a 12-month period. The hearScreenTM smartphone application employed automated test protocols operating on low-cost smartphones. A cloud-based data management and referral function allowed for remote monitoring for surveillance and follow up.Results: 6424 children (3–6 years) were screened for hearing loss with an overall referral rate of 24.9%. Only 39.4% of these children attended their follow-up appointment at a local clinic, of whom 40.5% referred on their second screening. Logistic regression analysis indicated that age, gender and environmental noise levels (1 kHz) had a significant effect on referral rates (p < 0.05). The quality index reflecting test operator test quality increased during the first few months of testing.Conclusion: Smartphone-based hearing screening can be used by CHWs to detect unidentified children affected by hearing loss within ECD centers. Active noise monitoring, quality indices of test operators and cloud-based data management and referral features of the hearScreenTM application allows for the asynchronous management of hearing screenings and follow-ups.

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Section: Discussionmentioning

confidence: 99%

Community-based hearing screening for young children using an mHealth service-delivery model

Hussein

Swanepoel

Mahomed

et al. 2018

Global Health Action

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“…The direct and indirect costs for the diagnosis and treatment of acute OM (AOM) in 2009 approached $3 billion and the number of all OM cases has estimated costs of treatment of up to $6 billion in the US annually (1)(2)(3). The scope of the problem is apparent with the observation that globally there are 709 million cases of AOM estimated per year of which 51% occur in children under the age of five (4). Moreover, children attending daycare outside the home, approximated at 4 million children in the US in 2011 (5), are fourfold more likely to have an incidence of AOM (6).…”

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confidence: 99%

“…As a result, OM is the most common reason for a doctor's visit in school age children and is associated with significant morbidity. Long-term hearing loss is a direct consequence of untreated OM with effusion (OME) (4,7,8). Clinical management of OM has relied heavily on antibiotic therapies (8,9), which has contributed to the emergence of antibiotic resistant strains of bacteria (10 -13).…”

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confidence: 99%

Comprehensive Proteomic and Metabolomic Signatures of Nontypeable Haemophilus influenzae-Induced Acute Otitis Media Reveal Bacterial Aerobic Respiration in an Immunosuppressed Environment

Harrison

Dubois

John-Williams

et al. 2016

Molecular & Cellular Proteomics

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A thorough understanding of the molecular details of the interactions between bacteria and host are critical to ultimately prevent disease. Recent technological advances allow simultaneous analysis of host and bacterial protein and metabolic profiles from a single small tissue sample to provide insight into pathogenesis. We used the chinchilla model of human otitis media to determine, for the first time, the most expansive delineation of global changes in protein and metabolite profiles during an experimentally induced disease. After 48 h of infection with nontypeable Haemophilus influenzae, middle ear tissue lysates were analyzed by high-resolution quantitative two-dimensional liquid chromatography-tandem mass spectrometry. Dynamic changes in 105 chinchilla proteins and 66 metabolites define the early proteomic and metabolomic signature of otitis media. Our studies indicate that establishment of disease coincides with actin morphogenesis, suppression of inflammatory mediators, and bacterial aerobic respiration. We validated the observed increase in the actin-remodeling complex, Arp2/3, and experimentally showed a role for Arp2/3 in nontypeable Haemophilus influenzae invasion. Direct inhibition of actin branch morphology altered bacterial invasion into host epithelial cells, and is supportive of our efforts to use the information gathered to modify outcomes of disease. The twenty-eight nontypeable Haemophilus influenzae proteins identified participate in carbohydrate and amino acid metabolism, redox homeostasis, and include cell wall-associated metabolic proteins. Quantitative characterization of the molecular signatures of infection will redefine our understanding of host response driven developmental changes during pathogenesis. These data represent the first comprehensive study of host protein and metabolite profiles in vivo in response to infection and show the feasibility of extensive characterization of host protein profiles during disease. Identification of novel protein targets and metabolic biomarkers will advance development of therapeutic and diagnostic options for treatment of disease. Molecular & Cellular Proteomics 15: 10.1074/mcp.M115.052498, 1117-1138, 2016.Our current understanding of the global changes that occur during infection is primarily based upon transcriptional profiles of either the host or the bacteria. However, a significant component of disease progression is dependent upon posttranscriptional processes. Recent advances in the application of two-dimensional tandem mass spectrometry have dramatically increased sensitivity to allow simultaneous analyses of multiple molecules from very small biological samples. In this study, we report the comprehensive proteomic and metabolomic profiling of middle ear tissues using samples that are smaller than those typically obtained from a human biopsy. Proteomic and metabolomic analyses of samples as small as biopsies will revolutionize the elucidation of the mechanisms From the

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“…1 Otitis media involves a spectrum of pathological conditions that affect the middle ear or its lining mucosa. The main diseases involved in otitis media spectrum are acute otitis media, otitis media with effusion, chronic suppurative otitis media, and mastoiditis.…”

Section: Introductionmentioning

confidence: 99%

“…1 The incidence among adults and elderly is generally estimated to be around 0.25%. 7 However, other studies reported a figure of up to 9%.…”

Section: Introductionmentioning

confidence: 99%

Otitis media among elderly: incidence, complication and prevention

Al-Sadeeq

Algarni

Alobaid

et al. 2018

Int J Community Med Public Health

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Though often considered a disease of children, otitis media can affect the elderly. The incidence of otitis media among elderly population is variable among countries, but generally low, with a value ranging from 0.25-9%. However, dangerous complications may occur. Otitis media is a complex spectrum of diseases that include acute otitis media, otitis media with effusion, suppurative otitis media, and mastoiditis. Otitis media in elderly doesn’t feature the classical presentation in children. Elderly patients experience otalgia with or without hearing loss or signs of inflammation. Infection may spread to either to adjacent structures leading to mastoiditis, petrositis, labyrinthitis, or facial nerve palsy, or intracranially leading to meningitis, subarachnoid abscess, subdural abscess, encephalitis, brain abscess, lateral or sigmoid venous sinus thrombosis, and otitis hydrocephalus. The mainstay strategies for prevention of otitis media are the adequate proper treatment of each infection, and tight control of modifiable risk factors such as tobacco smoking, immunosuppression, upper respiratory tract infection, allergy, and craniofacial abnormalities. Antimicrobial treatment should be continued for at least 10-14 years.

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Burden of Disease Caused by Otitis Media: Systematic Review and Global Estimates

Cited by 852 publications

References 41 publications

Community-based hearing screening for young children using an mHealth service-delivery model

Community-based hearing screening for young children using an mHealth service-delivery model

Comprehensive Proteomic and Metabolomic Signatures of Nontypeable Haemophilus influenzae-Induced Acute Otitis Media Reveal Bacterial Aerobic Respiration in an Immunosuppressed Environment

Otitis media among elderly: incidence, complication and prevention

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