Burden of frailty in the elderly population: perspectives for a public health challenge

Buckinx, Fanny; Rolland, Yves; Reginster, Jean‐Yves; Ricour, Céline; Pétermans, Jean; Bruyère, Olivier

doi:10.1186/s13690-015-0068-x

Cited by 347 publications

(292 citation statements)

References 68 publications

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“…The reduction in muscle strength with age is associated with an increased mortality risk,8 an increased susceptibility to risk of falls and, subsequently, an increased need for residential care. According to the World Health Organization, the global population of elderly people aged >60 years was 600 million in 2000 and is expected to rise to around 2 billion by 20509; thus, increased demand for medical and social care will inevitably increase, rising the financial costs of healthcare systems 10. Physical activity can undoubtedly delay the progression of ageing muscle affects,11, 12 but even physically active older individuals experience age‐associated muscle atrophy and weakness 13.…”

Section: Introductionmentioning

confidence: 99%

Redox homeostasis and age‐related deficits in neuromuscular integrity and function

Sakellariou

Lightfoot

Earl

et al. 2017

J cachexia sarcopenia muscle

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Skeletal muscle is a major site of metabolic activity and is the most abundant tissue in the human body. Age‐related muscle atrophy (sarcopenia) and weakness, characterized by progressive loss of lean muscle mass and function, is a major contributor to morbidity and has a profound effect on the quality of life of older people. With a continuously growing older population (estimated 2 billion of people aged >60 by 2050), demand for medical and social care due to functional deficits, associated with neuromuscular ageing, will inevitably increase. Despite the importance of this ‘epidemic’ problem, the primary biochemical and molecular mechanisms underlying age‐related deficits in neuromuscular integrity and function have not been fully determined. Skeletal muscle generates reactive oxygen and nitrogen species (RONS) from a variety of subcellular sources, and age‐associated oxidative damage has been suggested to be a major factor contributing to the initiation and progression of muscle atrophy inherent with ageing. RONS can modulate a variety of intracellular signal transduction processes, and disruption of these events over time due to altered redox control has been proposed as an underlying mechanism of ageing. The role of oxidants in ageing has been extensively examined in different model organisms that have undergone genetic manipulations with inconsistent findings. Transgenic and knockout rodent studies have provided insight into the function of RONS regulatory systems in neuromuscular ageing. This review summarizes almost 30 years of research in the field of redox homeostasis and muscle ageing, providing a detailed discussion of the experimental approaches that have been undertaken in murine models to examine the role of redox regulation in age‐related muscle atrophy and weakness.

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Section: Introductionmentioning

confidence: 99%

Redox homeostasis and age‐related deficits in neuromuscular integrity and function

Sakellariou

Lightfoot

Earl

et al. 2017

J cachexia sarcopenia muscle

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show abstract

“…There are few data on potential economic gains for frailty monitoring systems; early identification of the syndrome can help services allocate resources to those most in need, thus highlighting the importance of translating knowledge between researchers and caregivers, such as local and scientific evidence. (33,34) As a limitation of the study, the use of a cross-sectional design did not allow for finding of causality between the explanatory variables and outcome. The sample size may limit the generalization of the results, as the elderly were enrolled in reference centers for social assistance.…”

Section: Cras -Social Assistance In Referral Centersmentioning

confidence: 99%

Fragilidade de idosos em vulnerabilidade social

et al. 2017

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Objective: To identify the relationship between frailty, sociodemographic characteristics, and social vulnerability of the elderly enrolled in a primary care service. Methods: This was an exploratory, comparative, and cross-sectional study with a quantitative research approach performed with 247 elderly people enrolled in a primary care service, in a city in the interior of São Paulo. A questionnaire was used for socio-demographic characterization of the participants, and the Edmonton Frail Scale was used to evaluate frailty. Vulnerability was classified according to the Paulista Index of Social Vulnerability. Data were analyzed in a descriptive and inferential manner. All ethical recommendations were met. Results: There was a prevalence of frail elderly women, with a mean age of 68.5 (SD=7.3) years, low education, who were retirees. There was a statistically significant difference between frailty and the number of diseases reported (p<0.001). Frailty correlated negatively with social vulnerability (r=-0.043). Conclusion: These results should receive attention from public administrators to understand frailty of the elderly in a context of social vulnerability. ResumoObjetivo: Identificar a relação entre fragilidade, características sociodemográficos e vulnerabilidade social de idosos cadastrados em um serviço de atendimento primário. Métodos: Trata-se de um estudo exploratório, comparativo e transversal, com abordagem quantitativa de investigação realizado com 247 idosos cadastrados em um serviço de atendimento primário, em um município do interior paulista. Utilizou-se questionário para caracterização sócio demográfica dos participantes e Escala de Fragilidade de Edmonton, para avaliar a fragilidade. A vulnerabilidade foi classificada segundo Índice Paulista de Vulnerabilidade Social. Os dados foram analisados de forma descritiva e inferencial. Todas as recomendações éticas foram respeitadas. Resultados: Houve prevalência de idosos frágeis pertencentes ao gênero feminino, com média de idade de 68,5 (dp=7,3) anos, baixa escolaridade e aposentados. Houve diferença estatisticamente significativa entre fragilidade e número de doenças relatadas (p<0,001). A fragilidade se correlacionou negativamente com a vulnerabilidade social (r=-0,043). Conclusão: Os resultados encontrados devem suscitar atenção aos gestores públicos para a necessidade de conhecer a fragilidade de idosos em contexto de vulnerabilidade social.

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“…These rates are increasing with age and are higher in women and in people with low income and are increased even more when coexist with chronic diseases. In Southern European countries the percentages of frail is higher than the percentages in the North countries 11 . The 4,1% of European over 50 years old were frail and 37,4% were prefrail, 5,2% of the women were frail and the 42% pre fail, while men in the same age group, the 2,9% were frail and the 32,7% prefrail.…”

Section: Epidemiologymentioning

confidence: 91%

“…Elders between meals should take protein supplement, consisted of 1.2-1.5 g per kilogram of body mass per a day. Low vitamin D levels is associated with frailty so 1000 IU/day of vitamin D should be taken 11 . The administration of calcium and vitamin D supplements helps to reduce falls and fractures.…”

Section: Nutrition -Medicationmentioning

confidence: 99%

Frailty and bone health in European men

Giannopoulou¹

2017

JFSF

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Burden of frailty in the elderly population: perspectives for a public health challenge

Cited by 347 publications

References 68 publications

Redox homeostasis and age‐related deficits in neuromuscular integrity and function

Redox homeostasis and age‐related deficits in neuromuscular integrity and function

Fragilidade de idosos em vulnerabilidade social

Frailty and bone health in European men

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