Burden of non-communicable diseases among adolescents aged 10–24 years in the EU, 1990–2019: a systematic analysis of the Global Burden of Diseases Study 2019

Hay, Simon I.; Armocida, Benedetta; Monasta, Lorenzo; Sawyer, Susan Μ; Bustreo, Flavia; Segafredo, Giulia; Castelpietra, Giulio; Ronfani, Luca; Pasovic, Maja; Hay, Simon I; Abila, Derrick Bary; Abolhassani, Hassan; Accrombessi, Manfred; Adekanmbi, Victor; Ahmadi, Keivan; Hamad, Hanadi Al; Aldeyab, Mamoon A.; Al-Jumaily, Adel; Ancuceanu, Robert; Andrei, Cătălina Liliana; Andrei, Tudorel; Arumugam, Ashokan; Attia, Sameh; Aujayeb, Avinash; Ausloos, Marcel; Baker, Jennifer L.; Barone-Adesi, Francesco; Barra, Fabio; Barteit, Sandra; Basu, Sanjay; Baune, Bernhard T.; Béjot, Yannick; Belo, Luis; Bennett, Derrick; Bikbov, Boris; Bikov, András; Blyuss, Oleg; Breitner, Susanne; Brugger, Hermann; Carreras, Giulia; Carvalho, Márcia; Catapano, Alberico L.; Chandan, Joht Singh; Charalampous, Periklis; Chen, Simiao; Conde, Joao; Cruz‐Martins, Natália; Damiani, Giovanni; Dastiridou, Anna; Torre‐Luque, Alejandro de la; Dianatinasab, Mostafa; Silva, Diana Dias da; Douiri, Abdel; Dragioti, Elena; Bain, Luchuo Engelbert; Fagbamigbe, Adeniyi Francis; Fereshtehnejad, Seyed‐Mohammad; Ferrara, Pietro; Oliveira, José Miguel P. Ferreira de; Ferrero, Simone; Desideri, Lorenzo Ferro; Fischer, Florian; Fonseca, Diogo A.; Gaewkhiew, Piyada; Gaihre, Santosh; Gallus, Silvano; Fonseca, Mariana Gaspar; Gill, Paramjit; Glasbey, James C; Gorini, Giuseppe; Gupta, Vijai Kumar; Gurara, Mekdes Kondale; Haro, Josep María; Hasan, Mehedi; Havmoeller, Rasmus; Heibati, Behzad; Hellemons, Merel E.; Herţeliu, Claudiu; Hussain, Salman; Isola, Gaetano; Johnson, Olatunji; Jonas, Jost B.; Jóźwiak, Jacek Jerzy; Jürisson, Mikk; Kabir, Zubair; Karch, André; Kauppila, Joonas H; Kayode, Gbenga A; Khan, Moien AB; Khatab, Khaled; Kivimäki, Mika; Klugar, Miloslav; Klugarová, Jitka; Koly, Kamrun Nahar; Koyanagi, Ai; Kurmi, Om; Kusuma, Dian; Vecchia, Carlo La; Lacey, Ben; Lallukka, Tea; Lamnisos, Demetris; Langguth, Berthold; Larsson, Anders; Lauriola, Paolo; Lee, Paul H.; Leonardi, Matilde; Liu, An; Linehan, Christine; López‐Bueno, Rubén; Lorkowski, Stefan; Loureiro, Joana A.; Lunevičius, Raimundas; Magee, Laura A.; Magnani, Francesca Giulia; Majeed, Azeem; Makris, Konstantinos C.; Mathioudakis, Alexander G.; Mathur, Manu Raj; McGrath, John; Menezes, Ritesh G.; Mentis, Alexios-Fotios A; Meretoja, Atte; Meštrović, Tomislav; Jonasson, Junmei Miao; Miazgowski, Tomasz; Mirică, Andreea; Moccia, Marcello; Mohammed, Shafiu; Molokhia, Mariam; Mondello, Stefania; Muêller, U.; Mulita, Francesk; Munblit, Daniel; Negoi, Ionuț; Negoi, Ruxandra Irina; Nena, Evangelia; Noor, Nurulamin M; Nowak, Christoph; Ntaios, George; Nwatah, Vincent Ebuka; Oancea, Bogdan; Oguntade, Ayodipupo Sikiru; Ortíz, Alberto; Oţoiu, Adrian; Padrón-Monedero, Alicia; Palladino, Raffaele; Pană, Adrian; Panagiotakos, Demosthenes B.; Panda‐Jonas, Songhomitra; Pardhan, Shahina; Patel, Jay; Pedersini, Paolo; Peñalvo, José L.; Pensato, Umberto; Pereira, Renato B.; Perico, Norberto; Petcu, Ionela-Roxana; Polinder, Suzanne; Postma, Maarten; Rabiee, Mohammad; Rabiee, Navid; Raggi, Alberto; Rahimzadeh, Shadi; Rawaf, David Laith; Rawaf, Salman; Rehman, Faizan Ur; Remuzzi, Giuseppe; Riad, Abanoub; Rodriguez, Alina; Sacco, Simona; Saeb, Mohammad Reza; Safdarian, Mahdi; Sathian, Brijesh; Sattin, Davide; Saxena, Sonia; Scarmeas, Nikolaos; Schlee, Winfried; Schwendicke, Falk; Shamsizadeh, Morteza; Sharew, Nigussie Tadesse; Shiri, Rahman; Shivalli, Siddharudha; Shivarov, Velizar; Silva, João Pedro; Simpson, Colin R; Skou, Søren Thorgaard; Socea, Bogdan; Soyiri, Ireneous N; Steiropoulos, Paschalis; Straif, Kurt; Sun, Xiaohui; Tabarés‐Seisdedos, Rafael; Thiyagarajan, Arulmani; Topouzis, Fotis; Tovani‐Palone, Marcos Roberto; Truelsen, Thomas; Unim, Brigid; Eynde, Jef Van den; Vasankari, Tommi; Veroux, Massimiliano; Villafaina, Santos; Vinko, Matej; Violante, Francesco Saverio; Volovici, Victor; Wang, Yanzhong; Westerman, Ronny; Yadegarfar, Mohammad E; Yaya, Sanni; Zadnik, Vesna; Zumla, Alimuddin; Perel, Pablo; Beran, David

doi:10.1016/s2352-4642(22)00073-6

Cited by 70 publications

(51 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, several studies showed that between 40 and 75% of cases of childhood mortality were comprised by children with comorbidities [ 28 , 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, there is convincing data that regardless of the definition used, children with comorbidity have higher health care utilization and an increased risk of in-hospital mortality [20,28,[33][34][35].…”

Section: Findings In Relation To Previous Literaturementioning

confidence: 99%

“…For example, a recent European study showed that depending on the setting, between 10 and 38% of all ED visits were comprised by children with comorbidities [33]. Furthermore, several studies showed that between 40 and 75% of cases of childhood mortality were comprised by children with comorbidities [28,34,35].…”

Section: Findings In Relation To Previous Literaturementioning

confidence: 99%

See 2 more Smart Citations

Febrile children with comorbidities at the emergency department — a multicentre observational study

et al. 2022

View full text Add to dashboard Cite

We aimed to describe characteristics and management of children with comorbidities attending European emergency departments (EDs) with fever. MOFICHE (Management and Outcome of Fever in children in Europe) is a prospective multicentre study (12 European EDs, 8 countries). Febrile children with comorbidities were compared to those without in terms of patient characteristics, markers of disease severity, management, and diagnosis. Comorbidity was defined as a chronic underlying condition that is expected to last > 1 year. We performed multivariable logistic regression analysis, displaying adjusted odds ratios (aOR), adjusting for patient characteristics. We included 38,110 patients, of whom 5906 (16%) had comorbidities. Most common comorbidities were pulmonary, neurologic, or prematurity. Patients with comorbidities more often were ill appearing (20 versus 16%, p < 0.001), had an ED-Paediatric Early Warning Score of > 15 (22 versus 12%, p < 0.001), or a C-reactive protein > 60 mg/l (aOR 1.4 (95%CI 1.3–1.6)). They more often required life-saving interventions (aOR 2.7, 95% CI 2.2–3.3), were treated with intravenous antibiotics (aOR 2.3, 95%CI 2.1–2.5), and were admitted to the ward (aOR 2.2, 95%CI 2.1–2.4) or paediatric intensive care unit (PICU) (aOR 5.5, 95% CI 3.8–7.9). They were more often diagnosed with serious bacterial infections (aOR 1.8, 95%CI 1.7–2.0), including sepsis/meningitis (aOR 4.6, 95%CI 3.2–6.7). Children most at risk for sepsis/meningitis were children with malignancy/immunodeficiency (aOR 14.5, 8.5–24.8), while children with psychomotor delay/neurological disease were most at risk for life-saving interventions (aOR 5.3, 4.1–6.9) or PICU admission (aOR 9.7, 6.1–15.5).Conclusions: Our data show how children with comorbidities are a population at risk, as they more often are diagnosed with bacterial infections and more often require PICU admission and life-saving interventions. What is Known:• While children with comorbidity constitute a large part of ED frequent flyers, they are often excluded from studies. What is New:• Children with comorbidities in general are more ill upon presentation than children without comorbidities.• Children with comorbidities form a heterogeneous group; specific subgroups have an increased risk for invasive bacterial infections, while others have an increased risk of invasive interventions such as PICU admission, regardless of the cause of the fever.

show abstract

“…Furthermore, several studies showed that between 40 and 75% of cases of childhood mortality were comprised by children with comorbidities [ 28 , 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Findings In Relation To Previous Literaturementioning

confidence: 99%

Section: Findings In Relation To Previous Literaturementioning

confidence: 99%

See 1 more Smart Citation

Febrile children with comorbidities at the emergency department — a multicentre observational study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Developmental delay (DD) and epilepsy (EPI) continue to increase in prevalence. ASD [ 2 ] and EPI [ 3 ] overlap with psychiatric disorders, which are also growing in prevalence in children and adolescents [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Central Nervous System Metabolism in Autism, Epilepsy and Developmental Delays: A Cerebrospinal Fluid Analysis

et al. 2022

View full text Add to dashboard Cite

Neurodevelopmental disorders are associated with metabolic pathway imbalances; however, most metabolic measurements are made peripherally, leaving central metabolic disturbances under-investigated. Cerebrospinal fluid obtained intraoperatively from children with autism spectrum disorder (ASD, n = 34), developmental delays (DD, n = 20), and those without known DD/ASD (n = 34) was analyzed using large-scale targeted mass spectrometry. Eighteen also had epilepsy (EPI). Metabolites significantly related to ASD, DD and EPI were identified by linear models and entered into metabolite–metabolite network pathway analysis. Common disrupted pathways were analyzed for each group of interest. Central metabolites most involved in metabolic pathways were L-cysteine, adenine, and dodecanoic acid for ASD; nicotinamide adenine dinucleotide phosphate, L-aspartic acid, and glycine for EPI; and adenosine triphosphate, L-glutamine, ornithine, L-arginine, L-lysine, citrulline, and L-homoserine for DD. Amino acid and energy metabolism pathways were most disrupted in all disorders, but the source of the disruption was different for each disorder. Disruption in vitamin and one-carbon metabolism was associated with DD and EPI, lipid pathway disruption was associated with EPI and redox metabolism disruption was related to ASD. Two microbiome metabolites were also detected in the CSF: shikimic and cis-cis-muconic acid. Overall, this study provides increased insight into unique metabolic disruptions in distinct but overlapping neurodevelopmental disorders.

show abstract

“…В систематическом анализе исследования «Глобальное бремя болезней» (Global Burden of Disease), посвященном неинфекционным заболеваниям подростков в возрасте 10-24 лет в Европейском союзе в 1990-2019 гг., репродуктивный опыт упущен вовсе. Отражена гинекологическая заболеваемость, но в совокупной группе других неинфекционных заболеваний -врожденные пороки развития, мочевые заболевания; гемоглобинопатии и гемолитические анемии; эндокринные, метаболические, кроветворные и иммунные нарушения; расстройства полости рта [12].…”

Section: Introductionunclassified

Structure of reproductive losses of adolescent girls and women of reproductive age in the Tyumen

et al. 2022

View full text Add to dashboard Cite

Introduction. The reproductive experience of women 18–44 years of age is quantitatively superior to adolescent girls. The structure of reproductive losses of adolescents, its identity or difference in comparison with women of reproductive age is extremely unexplored.Aim. To compare the structure of reproductive losses of adolescents and women of reproductive age on the example of the Tyumen region.Materials and methods. A retro-prospective analytical study carried out. Study period – 2016–2021. Adolescent girls and women of reproductive age with completed pregnancies included.Results and discussion. In the Tyumen region, the frequency of reproductive losses approaches childbirth (42.83% and 57.17%), mainly represented by medical abortion (59.98%). The proportion of completed pregnancies among adolescent girls (1.14%) is inferior to women of reproductive age (98.86%). Adolescent girls are characterized by the completion of pregnancy by childbirth (OR = 1.68), a high frequency of medical abortion (OR = 1.71). Reproductive losses up to 12 weeks distinguish completed pregnancies in women of reproductive age (OR = 1.68); unsuccessful abortion attempt, criminal and unspecified types of abortion before 12 weeks and other abnormal products of conception after 12 weeks are their exclusive markers. The pregnancy outcome is associated with age: with adolescents – medical abortion before (OR = 1.71) and after 12 weeks (OR = 2.01); with reproductive age – other abnormal products of conception (OR = 1.64) and ectopic pregnancy (OR = 6.15). Reproductive losses are associated with gestational age before/after 12 weeks: with adolescents – spontaneous abortion after 12 weeks (OR = 2.55); with reproductive age – other types of abortion (OR = 20.37), medical abortion (OR = 1.93), other abnormal products of conception (OR = 1.89) before 12 weeks and spontaneous abortion (OR = 5.42) after 12 weeks.Conclusion. In the Tyumen region, reproductive losses in frequency compete with childbirth. Augmented the concept of the abortion-contraceptive behavior of modern society based on the association of medical abortion with adolescent girls that we have identified. The structure of reproductive losses is associated with a woman’s age period and gestational age.

show abstract

Burden of non-communicable diseases among adolescents aged 10–24 years in the EU, 1990–2019: a systematic analysis of the Global Burden of Diseases Study 2019

Cited by 70 publications

References 30 publications

Febrile children with comorbidities at the emergency department — a multicentre observational study

Febrile children with comorbidities at the emergency department — a multicentre observational study

Central Nervous System Metabolism in Autism, Epilepsy and Developmental Delays: A Cerebrospinal Fluid Analysis

Structure of reproductive losses of adolescent girls and women of reproductive age in the Tyumen

Contact Info

Product

Resources

About