Burden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countries: France, Spain and Belgium

Ougier, Eva; Fiore, Karine; Rousselle, Christophe; Assunção, Ricardo; Martins, Carla; Buekers, Jurgen

doi:10.1016/j.ijheh.2021.113747

Cited by 17 publications

(6 citation statements)

References 47 publications

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“…Ougier et al. assessed the cost of the cadmium-related burden of osteoporosis-associated fractures in three European countries (Belgium, France, and Spain) based on the Human Biomonitoring (HBM) study conducted in three countries, suggesting that cadmium exposure plays a major contributory role in the overall societal costs associated with osteoporosis ( 29 ). These findings were consistent with our own.…”

Section: Discussionmentioning

confidence: 99%

Relationship between blood cadmium levels and bone mineral density in adults: a cross-sectional study

Lei,

Guo,

Xie

et al. 2024

Front. Endocrinol.

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IntroductionOsteoporosis, a disease of reduced bone mass and microstructural deterioration leading to fragility fractures, is becoming more prevalent as aging progresses, significantly increasing the socioeconomic burden. In past studies, there has been a growing awareness of the harmful effects of heavy metals on bone, with cadmium being a significant exposure factor. The purpose of this study was to look into the association between adult bone mineral density(BMD) and blood cadmium levels.MethodsBased on information from the 2013–2014, 2017–2018 NHANES, weighted multiple regression, generalized weighted modeling, and smoothed curve fitting were utilized to investigate the association between blood cadmium and femur BMD. Furthermore, subgroup analyses were conducted to investigate any differences in the associations between age, sex, race, chronic kidney disease, and diabetes.ResultsIn 2,146 participants, blood cadmium levels and total femur [-0.02 (-0.03, -0.01), 0.0027], femoral neck [-0.01 (-0.02, -0.00), 0.0240], femoral trochanter [-0.01 (-0.02, -0.00), 0.0042], and intertrochanteric femoral trochanter [-0.02 (-0.03, -0.00), 0.0101] BMD were negatively correlated. Subgroup analyses showed that this association was more pronounced in women, non-Hispanic white people and other Hispanics, and those with chronic kidney disease and diabetes. Our results pointed to a negative relationship between femoral BMD and blood cadmium. This negative association varied by age, sex, race, diabetes, and chronic kidney disease. In particular, bone mineral density was more significantly negatively affected by blood cadmium levels in groups with diabetes and chronic kidney disease.ConclusionOur findings demonstrated a significant negative association between blood cadmium levels and bone mineral density in a population of U.S. adults.

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Section: Discussionmentioning

confidence: 99%

Relationship between blood cadmium levels and bone mineral density in adults: a cross-sectional study

Lei,

Guo,

Xie

et al. 2024

Front. Endocrinol.

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“…The relationship between blood Cd level and osteoporosis has been revealed in a small number of cross-sectional studies ( 29 ). Moreover, a recent study reported that Cd exposure was associated with an up to 23% increase in the incidence of osteoporosis, and the absolute cost of the burden of osteoporosis-related fractures caused by Cd is estimated to range between EUR€ 0.12 and 2.6 billion ( 30 ). Furthermore, Chung revealed that blood Cd concentrations of >1.0 μg/L and >0.5 μg/L were independent risk factors for incident osteoporosis in 243 participants and in 121 women, respectively, from the 2001 to 2002 Korea Genome and Epidemiology Study ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Relationship of blood heavy metals and osteoporosis among the middle-aged and elderly adults: A secondary analysis from NHANES 2013 to 2014 and 2017 to 2018

Huang

Wang

et al. 2023

Front. Public Health

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ObjectiveThis study aimed to assess the relationship between blood heavy metals and a higher prevalence of osteoporosis in middle-aged and elderly US adults using the National Health and Nutritional Examination Surveys (NHANES).MethodsThe secondary data analysis was performed using the data of NHANES 2013–2014 and 2017–2018. We used the information, including physical examination, laboratory tests, questionnaires, and interviews, provided by participants in NHANES. Logistic regression and weighted quantile sum (WQS) regression models were used to explore the relationships between levels of blood heavy metals and a higher prevalence of osteoporosis.ResultsA total of 1,777 middle-aged and elderly participants were analyzed in this study, comprising 115 participants with osteoporosis and 1,662 without osteoporosis. Adjusted model 1 showed a significant positive relationship between cadmium (Cd) levels and a higher prevalence of osteoporosis (quartile 2, OR = 7.62; 95% CI, 2.01–29.03; p = 0.003; quartile 3, OR = 12.38; 95% CI, 3.88–39.60; p < 0.001; and quartile 4, OR = 15.64; 95% CI, 3.22–76.08; p = 0.001). The fourth quartile of selenium (Se) level (OR = 0.34; 95% CI, 0.14–0.39; p < 0.001) led to a lower prevalence of osteoporosis and exerted a protective effect on model 1. Other models produced similar results to those of model 1. A subgroup analysis showed that Cd levels were positively related to a higher prevalence of osteoporosis in all three models in women, while this relationship was not found in men. The fourth quartile of the Se level was related to a lower prevalence of osteoporosis in both male and female analyses. A significant positive relationship was found between the blood Cd level and a higher prevalence of osteoporosis in the non-smoking subgroup. Blood Se level showed a protective effect on the fourth quartile in both the smoking and non-smoking subgroups.ConclusionBlood Cd level aggravated the prevalence of osteoporosis, while blood Se level could be a protective factor in osteoporosis among the US middle-aged and older populations.

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“…The benchmark dose limit (NOAEL equivalent) values have been calculated from different endpoints, including, albuminuria [ 112 , 113 ], enzyme-uria [ 114 ], diabetes [ 115 ], infertility [ 13 ], and bone loss [ 116 , 117 , 118 ]. These values all indicated that the toxicity of Cd occurs at very low body burden.…”

Section: Exposure Sources Dosimetry and Health Risk Assessmentmentioning

confidence: 99%

Is Environmental Cadmium Exposure Causally Related to Diabetes and Obesity?

Satarug

2023

Cells

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Cadmium (Cd) is a pervasive toxic metal, present in most food types, cigarette smoke, and air. Most cells in the body will assimilate Cd, as its charge and ionic radius are similar to the essential metals, iron, zinc, and calcium (Fe, Zn, and Ca). Cd preferentially accumulates in the proximal tubular epithelium of the kidney, and is excreted in urine when these cells die. Thus, excretion of Cd reflects renal accumulation (body burden) and the current toxicity of Cd. The kidney is the only organ other than liver that produces and releases glucose into the circulation. Also, the kidney is responsible for filtration and the re-absorption of glucose. Cd is the least recognized diabetogenic substance although research performed in the 1980s demonstrated the diabetogenic effects of chronic oral Cd administration in neonatal rats. Approximately 10% of the global population are now living with diabetes and over 80% of these are overweight or obese. This association has fueled an intense search for any exogenous chemicals and lifestyle factors that could induce excessive weight gain. However, whilst epidemiological studies have clearly linked diabetes to Cd exposure, this appears to be independent of adiposity. This review highlights Cd exposure sources and levels associated with diabetes type 2 and the mechanisms by which Cd disrupts glucose metabolism. Special emphasis is on roles of the liver and kidney, and cellular stress responses and defenses, involving heme oxygenase-1 and -2 (HO-1 and HO-2). From heme degradation, both HO-1 and HO-2 release Fe, carbon monoxide, and a precursor substrate for producing a potent antioxidant, bilirubin. HO-2 appears to have also anti-diabetic and anti-obese actions. In old age, HO-2 deficient mice display a symptomatic spectrum of human diabetes, including hyperglycemia, insulin resistance, increased fat deposition, and hypertension.

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Burden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countries: France, Spain and Belgium

Cited by 17 publications

References 47 publications

Relationship between blood cadmium levels and bone mineral density in adults: a cross-sectional study

Relationship between blood cadmium levels and bone mineral density in adults: a cross-sectional study

Relationship of blood heavy metals and osteoporosis among the middle-aged and elderly adults: A secondary analysis from NHANES 2013 to 2014 and 2017 to 2018

Is Environmental Cadmium Exposure Causally Related to Diabetes and Obesity?

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