Burden of valvular heart disease, 1990-2017: Results from the Global Burden of Disease Study 2017

Abstract

Background Valvular heart disease (VHD) is expected to cause an increase in public-health problems in the coming years, especially in elderly populations. We aim to estimate the incidence, mortality, and burden of VHD, by age, from 1990 to 2017 in 195 countries and territories. Methods We estimated the incidence, mortality, and burden of VHD based on the Global Burden of Disease Study 2017. All metrics are presented with their 95% uncertainty intervals (UIs). The Socio-demographic Index was used to identify whether developmental status correlates with health outcomes. Results The global incidence of rheumatic heart disease (RHD) decreased by 8.67% between 1990 and 2017, while that of non-rheumatic VHD (NRVHD) increased by 45.10%. There was a 54.00% decrease in age-standardized death rate (ASDR) for RHD, but a small and non-significant decrease (-3.00%) in the ASDR for NRVHD. The global age-standardized disability-adjusted life years (DALY) rate of RHD decreased by 53.52%, while there was a 12.62% reduction in the age-standardized DALY rate of NRVHD. Conclusions The burden from different VHDs demonstrated a diverse change at a global level between 1990 and 2017. Although RHD burden has an obvious means of mitigation, a substantially high incidence of NRVHD was observed over this time period, especially in the elderly, which may lead to high health care costs and signify the potential for even higher costs in the future.

Cardiac Cachexia Associated With Valvular Heart Failure

“…Early diagnosis and prompt treatment of cardiac conditions are essential in the prevention of cardiac cachexia and its complications [ 26 ]. Valvular heart disease (VHD) is an essential cause of cardiovascular disease and complications in patients with aortic stenosis [ 28 , 29 ]. VHD is seen in 2.5% of the US population; it can be the primary cardiovascular risk for ventricular dysfunction due to the detrimental hemodynamic loading [ 30 ].…”

Artificial intelligence for the echocardiographic assessment of valvular heart disease

“…The global incidence of valvular heart disease (VHD) has increased by 45% in the last 30 years, with an annual incidence of 401 new cases per 100 000 people 1. This is due to an expanding ageing population and age-related VHD 1.…”

“…The global incidence of valvular heart disease (VHD) has increased by 45% in the last 30 years, with an annual incidence of 401 new cases per 100 000 people 1. This is due to an expanding ageing population and age-related VHD 1. Echocardiography is the most common imaging modality used to identify patients with VHD as it is non-invasive, portable, widely available and cost-effective, and provides real-time assessment of cardiac structure and function 2.…”

Low-Density Lipoprotein Cholesterol and Mortality Risk in Elderly Patients Undergoing Valve Replacement Surgery: A Propensity Score Matching Analysis

“…It was estimated that more than 42 million people worldwide suffered from VHD ( 1 ). In developing counties, due to the high incidence of rheumatic heart disease, as well as expanding of the aging population (age ≥ 60 years), hence, with the increase in the incidence of degenerative valvular disease ( 2 , 3 ), more attention should be drawn to VHD. Valve replacement surgery (VRS) is the treatment of choice for VHD, however, the surgical mortality was high in the elderly population ( 4 , 5 ).…”