Burkholderia cepacia Sepsis Among Neonates

Abstract

Burkholderia cepacia is a rare cause of sepsis in newborns and its transmission involves human contact with heavily contaminated medical devices and disinfectants. The authors aimed to determine epidemiology, clinical features, antibiotic sensitivity pattern, complications and outcome of blood culture proven B. cepacia infections in 12 neonates. All neonates were outborn, 5 preterm and 7 term. B. cepacia was isolated from blood in all and concurrently from CSF in three neonates. Lethargy and respiratory distress (41.7 %) were major presenting features. Five newborns (41.7 %) required mechanical ventilation for 3-7 d. Highest bacterial susceptibility was observed for meropenem (100 %), followed by cefoperazone-sulbactam, piperacillin-tazobactam, sulfamethoxazole-trimethoprim (all 83 %), ceftazidime (75 %) and ciprofloxacin (42 %). Piperacillin-tazobactam, ciprofloxacin and cotrimoxazole either singly or in combination led to complete recovery of 11 (91.7 %) newborns; one developed hydrocephalus. Eight of nine infants who completed 6 mo follow up were normal. Prompt recognition and appropriate antibiotic therapy for B. cepacia infection results in complete recovery in majority.

Pattern of clinical manifestation and antibiotics sensitivity of Burkholderia Cepacia sepsis in Neonatal Intensive Care Unit of tertiary care centre of North India

“…Since all the neonates were inborn and developed early neonatal septicemia, they probably acquired it from the environment. The pathogenicity of this complex is suggested by the clinical picture of these neonates, all of whom had signs and symptoms suggestive of sepsis and nearly 77.78% had thrombocytopenia which correlates with the study by Bhise et al and Patra et al 9,10 Although the ratio of preterm and term neonates is significantly indicative of increased propensity of preterm babies developing Burkholderia sepsis, and preterm neonates had increased average hospital stay and poorer prognosis. There was also no significant correlation with operative mode of delivery as more than half of the neonates were born of normal vaginal delivery and this is in synchronization with findings of Patra et al 10 A diagnostic clinching feature was development of progressive thrombocytopenia which was found in nearly 78% neonates with Burkholderia sepsis.…”

Global burden, point sources, and outbreak management of healthcare-associatedBurkholderia cepaciainfections: An integrative review

“…Third, we aimed to describe infection prevention and control measures used to contain and arrest the outbreaks. B. cepacia HAIs have been documented in patients from various age groups including neonates, [23][24][25][26] pediatric patients, [27][28][29][30][31][32] young adults, 33,34 adults [35][36][37][38][39] and ageing patients, 40,41 yet it is mostly reported in adults. Like many opportunistic pathogens, members of BCC affect immunocompromised individuals including patients affected with cystic fibrosis, 31,[42][43][44][45][46] patients with hematological diseases, 4,[47][48][49] postoperative patients, 36,50,51 and hemodialysis patients.…”

Discrimination of Sri Lankan black teas using fluorescence spectroscopy and linear discriminant analysis

“…TLS is a non‐invasive and non‐destructive technique where the sample is subjected only to excitation light. It has previously been used successfully for applications such as discrimination of fuels, water monitoring and classification of oils and in our previous study on the classification of geographically dissimilar teas …”