Burkholderia mallei and Glanders

Khakhum, Nittaya; Tapia, Daniel; Torres, Alfredo G.

doi:10.1007/978-3-030-03071-1_7

Cited by 8 publications

(7 citation statements)

References 94 publications

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“…Burkholderia s.s. is formed by three groups of species: (a) the Burkholderia pseudomallei group (composed of 8 species), (b) the Burkholderia species that are mostly plant pathogenic bacteria (containing 4 species), and (c) the Burkholderia cepacia complex (Bcc) (composed of 25 species). The B. pseudomallei group is of worldwide importance because the species B. pseudomallei and Burkholderia mallei cause the mortal (if not treated) melioidosis diseases in humans and animals, and glanders, specifically in equines, respectively [ 6 , 7 ]. Recently, “ Burkholderia mayonis ” and “ Burkholderia savannae ” were described within the B. pseudomallei group [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Compilation of the Antimicrobial Compounds Produced by Burkholderia Sensu Stricto

et al. 2023

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Due to the increase in multidrug-resistant microorganisms, the investigation of novel or more efficient antimicrobial compounds is essential. The World Health Organization issued a list of priority multidrug-resistant bacteria whose eradication will require new antibiotics. Among them, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae are in the “critical” (most urgent) category. As a result, major investigations are ongoing worldwide to discover new antimicrobial compounds. Burkholderia, specifically Burkholderia sensu stricto, is recognized as an antimicrobial-producing group of species. Highly dissimilar compounds are among the molecules produced by this genus, such as those that are unique to a particular strain (like compound CF66I produced by Burkholderia cepacia CF-66) or antimicrobials found in a number of species, e.g., phenazines or ornibactins. The compounds produced by Burkholderia include N-containing heterocycles, volatile organic compounds, polyenes, polyynes, siderophores, macrolides, bacteriocins, quinolones, and other not classified antimicrobials. Some of them might be candidates not only for antimicrobials for both bacteria and fungi, but also as anticancer or antitumor agents. Therefore, in this review, the wide range of antimicrobial compounds produced by Burkholderia is explored, focusing especially on those compounds that were tested in vitro for antimicrobial activity. In addition, information was gathered regarding novel compounds discovered by genome-guided approaches.

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Section: Introductionmentioning

confidence: 99%

Compilation of the Antimicrobial Compounds Produced by Burkholderia Sensu Stricto

et al. 2023

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“…Glanders is a zoonotic disease with a high degree of transmissibility to humans and mortality in solipeds (e.g., horses, mules, and donkeys). The infection is caused by the Gram-negative pathogen Burkholderia mallei (Bm) [1][2][3] . This historic biothreat pathogen has been intentionally used as a biological weapon a number of times because of its high transmissibility, mortality, and amenability for aerosolization [3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

“…The infection is caused by the Gram-negative pathogen Burkholderia mallei (Bm) [1][2][3] . This historic biothreat pathogen has been intentionally used as a biological weapon a number of times because of its high transmissibility, mortality, and amenability for aerosolization [3][4][5] . In addition, Bm is a non-motile intracellular pathogen with a complex intracellular lifestyle that uses a myriad of secreted effectors to allow survival and evasion of host immune responses 3,4 .…”

Section: Introductionmentioning

confidence: 99%

“…This historic biothreat pathogen has been intentionally used as a biological weapon a number of times because of its high transmissibility, mortality, and amenability for aerosolization [3][4][5] . In addition, Bm is a non-motile intracellular pathogen with a complex intracellular lifestyle that uses a myriad of secreted effectors to allow survival and evasion of host immune responses 3,4 . Due to the pathogen's inability to survive for long periods of time outside its mammalian host, Bm is thought to have evolved by reductive evolution from its genetically related counterpart, Burkholderia pseudomallei (Bpm), the causative agent of melioidosis 6,7 .…”

Section: Introductionmentioning

confidence: 99%

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Multicomponent gold nano-glycoconjugate as a highly immunogenic and protective platform against Burkholderia mallei

2020

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Burkholderia mallei (Bm) is a facultative intracellular pathogen and the etiological agent of glanders, a highly infectious zoonotic disease occurring in equines and humans. The intrinsic resistance to antibiotics, lack of specific therapy, high mortality, and history as a biothreat agent, prompt the need of a safe and effective vaccine. However, the limited knowledge of protective Bm-specific antigens has hampered the development of a vaccine. Further, the use of antigen-delivery systems that enhance antigen immunogenicity and elicit robust antigen-specific immune responses has been limited and could improve vaccines against Bm. Nanovaccines, in particular gold nanoparticles (AuNPs), have been investigated as a strategy to broaden the repertoire of vaccine-mediated immunity and as a tool to produce multivalent vaccines. To synthesize a nano-glycoconjugate vaccine, six predicted highly immunogenic antigens identified by a genome-wide bio- and immuno-informatic analysis were purified and coupled to AuNPs along with lipopolysaccharide (LPS) from B. thailandensis. Mice immunized intranasally with individual AuNP-protein-LPS conjugates, showed variable degrees of protection against intranasal Bm infection, while an optimized combination formulation (containing protein antigens OmpW, OpcP, and Hemagglutinin, along with LPS) showed complete protection against lethality in a mouse model of inhalational glanders. Animals immunized with different nano-glycoconjugates showed robust antigen-specific antibody responses. Moreover, serum from animals immunized with the optimized nano-glycoconjugate formulation showed sustained antibody responses with increased serum-mediated inhibition of adherence and opsonophagocytic activity in vitro. This study provides the basis for the rational design and construction of a multicomponent vaccine platform against Bm.

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“…There have been recent outbreaks in endemic areas including Western Asia (Iraq), South Asia (India) and South America (Brazil) (Khakhum et al, 2019;OIE, 2020).…”

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confidence: 99%

First outbreak of glanders in Nepal and possible implications for the animal sector

Acharya

Marahatta

Wilson³

2021

Transbound Emerg Dis

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Burkholderia mallei and Glanders

Cited by 8 publications

References 94 publications

Compilation of the Antimicrobial Compounds Produced by Burkholderia Sensu Stricto

Compilation of the Antimicrobial Compounds Produced by Burkholderia Sensu Stricto

Multicomponent gold nano-glycoconjugate as a highly immunogenic and protective platform against Burkholderia mallei

First outbreak of glanders in Nepal and possible implications for the animal sector

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