Burkitt‐like lymphoma presenting as a periodontal disease in AIDS patients: a report of two cases

Nittayananta, Wipawee; Apinawatavomgul, S; Chungpanich, S; Pongpanich, Settakorn; Kietthubthew, Suparp

doi:10.1111/j.1601-0825.1998.tb00293.x

Cited by 15 publications

(6 citation statements)

References 5 publications

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“…Approximately 4% of NHLs associated with HIV occur in the oral cavity5. The data available regarding intraoral HIV-associated BL indicate the gingiva as the most frequently affected site and primary occurrence in males3567810111213141516. Lesions on the palate, floor of the mouth, and lower jaw have also been reported1718.…”

Section: Discussionmentioning

confidence: 99%

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Intraoral HIV-associated Burkitt’s lymphoma: a rare case report with special emphasis on differential diagnosis

Kamat

Datar

Kanitkar

et al. 2019

JKAOMS

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Individuals with human immunodeficiency virus (HIV) infection present with unique intraoral manifestations of various neoplasms. Intraoral HIV-associated Burkitt's lymphoma is a rare presentation, especially in patients of Indian origin and may present as an initial sign of HIV. The objective of this paper is to report a rare case of Burkitt's lymphoma in an HIV-positive Indian patient along with a special emphasis on differential diagnosis. A 30-year-old Indian female presented with a solitary, well-defined, exophytic mass extending anteroposteriorly and buccolingually from the 35th to 38th regions with no evidence of intraosseous extension. An incisional biopsy was performed, and histopathology showed sheets of neoplastic lymphoid cells with numerous tingible body macrophages with clear cytoplasm, presenting a starry sky appearance, suggesting a diagnosis of BL. The tumor cells were positive for CD10, CD20, c-myc, and Epstein-Barr virus, with a nearly 100% Ki-67 proliferative index. The patient tested positive for HIV. This report indicates the importance of immunohistochemical analysis to differentiate Burkitt's lymphoma from other similar lesions like diffuse large B-cell lymphoma. Thorough knowledge of the clinical presentation, etiopathogenesis, histopathology, and immunoprofile of intraoral HIV-associated Burkitt's lymphoma is essential among clinicians and pathologists.

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Section: Discussionmentioning

confidence: 99%

“…The present case involved an exophytic growth with surface ulceration in the mandibular gingiva in a 30-year-old female patient. Clinically, BL may mimic a variety of orofacial pathologies; hence, clinical differential diagnosis should include periodontal disease, deep fungal infection, granulomatous diseases, and malignant neoplasms15.…”

Section: Discussionmentioning

confidence: 99%

Intraoral HIV-associated Burkitt’s lymphoma: a rare case report with special emphasis on differential diagnosis

Kamat

Datar

Kanitkar

et al. 2019

JKAOMS

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“…Some authors presented thickening of the periodontal ligament space [ 28 , 34 , 38 , 46 , and 70 ] and loss of the lamina dura [ 28 , 34 , and 46 ] as radiographic findings. The loss of the lamina dura in lymphoma patients may not simply be related to the effects of tumour cell infiltration.…”

Section: Discussionmentioning

confidence: 99%

“…Alveolar bone loss with oedema and pain may also occur which often mimics periodontal diseases. This may lead to ineffective treatments with antibiotics and supra- and subgingival scaling as described in studies presented by Spatafore et al [ 38 ], Dood et al [ 40 ], and Nittayamanta et al [ 46 ], where incorrect treatment further delayed the onset of lymphoma treatment, worsening the prognosis. Authors such as Richards et al [ 26 ], Forman et al [ 28 ], Groot et al [ 39 ], Rosenberg et al [ 44 ], Freitas et al [ 60 ] and Santos et al [ 62 ] presented clinical cases in which extractions were conducted simply because there was tooth mobility and periodontal pockets, or because of previous unsuccessful periodontal treatment or pericoronaritis.…”

Section: Discussionmentioning

confidence: 99%

Oral manifestations of lymphoma: a systematic review

Silva¹,

Ferreira²,

Leite³

et al. 2016

ecancer

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Lymphoma is a malignant disease with two forms: Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL). Non-Hodgkin’s lymphoma is diagnosed in extranodal sites in 40% of cases, and the head and neck region is the second most affected, with an incidence of 11–33%, while HL has a very low incidence in extranodal sites (1–4%). The aim of this study was to identify the oral manifestations of lymphoma through a systematic literature review, which we conducted using the PubMed, Lilacs, Embase, and Cochrane Library databases. We found 1456 articles, from which we selected 73. Among the intraoral findings, the most frequent were ulcerations, pain, swelling, and tooth mobility, while the extraoral findings included facial asymmetry and cervical, submandibular, and submental lymphadenopathy. Among the few studies reporting imaging findings, the most cited lesions included hypodense lesions with diffuse boundaries, bone resorptions, and tooth displacements. The publications reviewed highlight gaps in the areas of early detection, diagnosis, and proper treatment.

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“…Common manifestations of intraoral non-Hodgkin’s lymphoma include swelling and ulceration at various regions throughout the oral cavity (involving the tonsils, gingiva, tongue, palate, and buccal mucosa), tooth mobility, and pain (Ardekian et al, 1999, Richards et al, 2000). As the manifestation of oral lymphomas mimic symptoms of periodontal disease, osteomyelitis, or other diseases (Richards et al, 2000), misdiagnosis often delays initiation of proper treatment resulting in worsened disease outcome (Dodd et al, 1992, Nittayananta et al, 1998, Spatafore et al, 1989). Thus, understanding how EBV contributes to oral lymphomagenesis will be important in uncovering virally derived biomarkers for early diagnosis and treatment.…”

Section: Ebv and Oral Lymphoproliferative Diseasesmentioning

confidence: 99%

Epstein–Barr virus in the pathogenesis of oral cancers

2017

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Epstein-Barr virus (EBV) is a ubiquitous gamma-herpesvirus that establishes a lifelong persistent infection in the oral cavity and is intermittently shed in the saliva. EBV exhibits a biphasic life cycle, supported by its dual tropism for B lymphocytes and epithelial cells, which allows the virus to be transmitted within oral lymphoid tissues. While infection is often benign, EBV is associated with a number of lymphomas and carcinomas that arise in the oral cavity and at other anatomical sites. Incomplete association of EBV in cancer has questioned if EBV is merely a passenger or a driver of the tumorigenic process. However, the ability of EBV to immortalize B cells and its prevalence in a subset of cancers has implicated EBV as a carcinogenic cofactor in cellular contexts where the viral life cycle is altered. In many cases, EBV likely acts as an agent of tumor progression rather than tumor initiation, conferring malignant phenotypes observed in EBV-positive cancers. Given that the oral cavity serves as the main site of EBV residence and transmission, here we review the prevalence of EBV in oral malignancies and the mechanisms by which EBV acts as an agent of tumor progression. Oral Diseases (2018) 24, 497-508

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Burkitt‐like lymphoma presenting as a periodontal disease in AIDS patients: a report of two cases

Cited by 15 publications

References 5 publications

Intraoral HIV-associated Burkitt’s lymphoma: a rare case report with special emphasis on differential diagnosis

Intraoral HIV-associated Burkitt’s lymphoma: a rare case report with special emphasis on differential diagnosis

Oral manifestations of lymphoma: a systematic review

Epstein–Barr virus in the pathogenesis of oral cancers

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