Burkitt Lymphoma in Adult With Atypical Clinical Presentation Primarily Involving the Oral Soft Tissue

Garcia, Natália Galvão; Rodrigues, Moacyr Tadeu Vicente; Aleixo, Rodrigo Queiroz; Oliveira, Denise Tostes

doi:10.1097/scs.0000000000003681

Cited by 10 publications

(5 citation statements)

References 11 publications

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“…5,6 Soft tissue and bone infections, benign odontogenic cysts, and malignant tumors (Langerhans cell histiocytosis, Ewing sarcoma, non-Hodgkin lymphomas) should be considered in the differential diagnosis in childhood and adults. 7,8 Burkitt lymphoma may show signs such as tooth displacement, dental loss, facial nerve palsy, and orbital swelling. 9,10 Patients who apply to the dentist with oral and dental problems and suspected Burkitt lymphoma should be urgently referred to pediatric hematology-oncology centers for diagnosis and treatment.…”

Section: Discussionmentioning

confidence: 99%

A pediatric case with disseminated Burkitt lymphoma presenting with facial soft tissue swelling and dental pain

Okur

Vural

Akdemir

et al. 2023

Preprint

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Burkitt and Burkitt-like lymphomas constitute 40% of childhood lymphomas and are malignancies that require urgent diagnosis and treatment. Here, we present a case of a 10-year-old male patient who was diagnosed with Burkitt lymphoma and applied to the dentist with complaints of pain in the left upper molars and facial swelling for 2 weeks. Magnetic resonance imaging showed significant soft tissue swelling around the mandible and maxillary tooth roots in the lower and upper jaws. The patient was diagnosed with Burkitt lymphoma in the histopathological examination of the gingival biopsy. Diffuse bone marrow involvement and hyperuricemia due to tumor lysis syndrome were detected in this pediatric patient. The patient with stage IV Burkitt lymphoma has been successfully treated with intensive chemotherapy protocols and has been in remission for 5 years. Burkitt lymphoma should be considered in the differential diagnosis of soft tissue swellings in the jaw and orofacial region presenting with dental pain in childhood.

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Section: Discussionmentioning

confidence: 99%

A pediatric case with disseminated Burkitt lymphoma presenting with facial soft tissue swelling and dental pain

Okur

Vural

Akdemir

et al. 2023

Preprint

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“…Isolated oral SBL in adults is rare, with only few reports 21 , 22. Clinically, these lesions may resemble various oral pathologies¸ even of benign or reactive nature, including inflammatory periodontal processes 23.…”

Section: Discussionmentioning

confidence: 99%

Intraoral EBV-positive sporadic Burkitt lymphoma in an elderly patient with bilateral presentation

Pedraza¹,

Arboleda²,

Sánchez‐Romero³

et al. 2019

Autops. Case Rep.

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Sporadic Burkitt lymphoma (SBL) is a variant of Burkitt lymphoma that occurs worldwide, affecting mainly children and young adults. Association with Epstein-Barr virus (EBV) can be identified in approximately 20-30% of cases. Herein we described a case of a 63-year-old male presenting intraoral bilateral mandibular swelling, subjacent to fixed dental prosthesis, with one month of duration. Incisional biopsies were performed, and after two days, the patient was hospitalized due to malaise and breathing difficulty, and died after a week when an abdominal tumor was detected. The mandibular biopsies revealed a diffuse proliferation of medium-sized monomorphic atypical lymphoid cells exhibiting numerous mitoses and areas of “starry-sky” pattern. The tumor showed immunohistochemical positivity for CD20, CD10, Bcl-6, and Ki-67 (≈ 100%); it was negative for CD3, Bcl-2, Vs38c, and MUM-1. Positivity for EBV was found by in situ hybridization. The final diagnosis was intraoral SBL positive for EBV. Clinical, morphological and molecular criteria are necessary for the correct diagnosis of aggressive B-cell neoplasms positive for EBV in elderly patients.

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“…Three variants have been identified: endemic, sporadic and immunodeficiency-associated. 2 Epidemiologically, it predominantly affects males, mainly children and young adults, accounting for 3% of cases. Clinically, at the oral cavity level, the BL tumor is surrounded by an erythematous zone, painful to palpation, accompanied by dental displacement and mobility, intense swelling that can affect the maxillary sinus and/or the nasal pit, sanguineous-purulent nasal discharge, and cervical adenopathies.…”

Section: Introductionmentioning

confidence: 99%

Immunodeficiency-Associated Burkitt’s lymphoma in pediatric patients: a clinical case report

2018

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Burkitt's lymphoma, a form of non-Hodgkin lymphoma, is a neoplastic monoclonal proliferation of lymphoid cells in areas of the immune system. It can occur in HIV-positive patients, as AIDS is related to the development of non-Hodgkin lymphoma. Burkitt's lymphoma is a rare subtype, highly prevalent in patients with AIDS. Incisional biopsy, in situ hybridization and computerized axial tomography are the appropriate tests to determine the characterize of the lesions. The case of a 4-year-old HIV-positive patient, who developed Burkitt's lymphoma of the oral cavity, is reported in this paper. The aim of this case report is to describe the course of the pathology, taking into account its clinical imaging characteristics and treatment.

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Burkitt Lymphoma in Adult With Atypical Clinical Presentation Primarily Involving the Oral Soft Tissue

Cited by 10 publications

References 11 publications

A pediatric case with disseminated Burkitt lymphoma presenting with facial soft tissue swelling and dental pain

A pediatric case with disseminated Burkitt lymphoma presenting with facial soft tissue swelling and dental pain

Intraoral EBV-positive sporadic Burkitt lymphoma in an elderly patient with bilateral presentation

Immunodeficiency-Associated Burkitt’s lymphoma in pediatric patients: a clinical case report

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