Burkitt lymphoma of the head and neck: An international collaborative study

Arboleda, Lady Paola Aristizábal; Rodrigues-Fernandes, Carla Isabelly; Mariz, Bruno Augusto Linhares Almeida; Andrade, Bruno Augusto Benevenuto de; Abrahão, Aline Corrêa; Agostini, Michelle; Romañach, Mário José; Pontes, Hélder Antônio Rebelo; Fonseca, Felipe Paiva; Robinson, Liam; Heerden, W.F.P. Van; Carlos, Román; Tager, Elena María José Román; Hoffmann, Iva Loureiro; Cardinalli, Izilda Aparecida; Mendonça, Regina Maria Holanda de; Carvalho, Marianne de Vasconcelos; Barros, Ana Maria Ipólito; Rocha, André Caroli; Khurram, Syed Ali; Speight, Paul M.; Lopes, Márcio Ajudarte; Vargas, Pablo Agustı́n; Almeida, Oslei Paes de; Santos‐Silva, Alan Roger

doi:10.1111/jop.13209

Cited by 13 publications

(6 citation statements)

References 16 publications

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“…This could be explained by the fact that NHL includes a wide variety of histological subtypes with different age predilections [ 39 ]. Burkitt lymphoma, for instance, is known to be predominant in infants and young adults [ 40 ]; this was also evident in our study as the youngest age (3.5 years) in the study sample was of a case diagnosed as Burkitt lymphoma. On the other hand, other types of lymphoma, such as DLBCL, are more common in adults.…”

Section: Discussionsupporting

confidence: 75%

Oral and para-oral lymphomas: a 10-year multi-center retrospective study in Egypt with time series analysis and forecasting to 2030

et al. 2022

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Background Little is known about the epidemiology of lymphomas occurring in oral and para-oral sites, especially in developing countries such as Egypt. Hence, the aim of this study was to describe the frequency and time trends of oral and para-oral lymphomas in Cairo governorate from 2010 to 2019, with forecasting to 2030, and to examine relations between age, gender, site and type of lymphoma. Methods Histopathological reports of patients diagnosed with oral and para-oral lymphomas from 2010 to 2019 were retrospectively retrieved from archives of six different centers in Cairo governorate. Data regarding age, gender and site was collected and associations between types of lymphoma and these variables were detected using appropriate statistical methods. The significance level was set at p ≤ 0.05. Time series analysis was used to determine the trend of lymphoma frequency within 10 years of the study and to predict frequency until 2030. Results Lymphomas constituted 2.86% of oral and para-oral lesions. Non-Hodgkin lymphoma was more common than Hodgkin lymphoma. Patients with non-Hodgkin lymphoma showed a higher median age than patients with Hodgkin lymphoma (p = 0.001). Non-Hodgkin lymphoma was more prone to occur intra-orally (p = 0.014). No statistical significance was observed in gender distribution between Hodgkin and non-Hodgkin lymphoma. Even though no specific time trend was observed from 2010 to 2019, forecasting for frequency of lymphomas through 10 years (2020 to 2030) showed a predicted increase. Conclusions The findings of this study were consistent with majority of other studies held in various geographic regions. The study revealed that frequency of oral and para-oral lymphomas in Cairo governorate is expected to rise; hence, oral pathologists should be more clinically suspicious and expect to encounter these lesions more in their practice within the upcoming years.

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Section: Discussionsupporting

confidence: 75%

Oral and para-oral lymphomas: a 10-year multi-center retrospective study in Egypt with time series analysis and forecasting to 2030

et al. 2022

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“…The authors found a prevalence of BL and the main signs and symptoms were unilateral tonsillar enlargement, alteration in appearance of the tonsil, and cervical lymphadenopathy ( 19 ). Although our study reported few clinical manifestations in the oral and maxillofacial region, it is important to emphasize clinical features such as bone destruction, tooth mobility, ulceration, tooth displacement, and oral bleeding, since they are frequent clinical signs of BL ( 21 ). Other clinical aspects of relevance for the dentist, and which were not reported in this study due to the exclusion criteria, are swelling and gingival bleeding, as these signs need to be carefully evaluated in order to exclude gingival infiltration of leukemia or Langerhans cell histiocytosis ( 15 ).…”

Section: Discussionmentioning

confidence: 88%

“…Thyroglossal cyst (31%), plunging ranula (17%), and lymphangioma (16%) have been the main diagnoses of head and neck masses in children and adolescents ( 20 ). However, it is important to emphasize that rapidly growing masses causing local destruction at presentation are features that should lead to greater suspicion of malignancy ( 12 , 21 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical manifestations of head and neck cancer in pediatric patients, an analysis of 253 cases in a single Brazilian center

Arboleda¹,

Pérez-de-Oliveira²,

Hoffmann³

et al. 2022

Med Oral

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Background Pediatric head and neck cancer (PHNC) is rare and its nonspecific clinical manifestations may often lead to delayed diagnosis. We aimed to describe the signs, symptoms, and clinicopathological characteristics of PHNC. Material and Methods Medical records were retrospectively reviewed for all PHNC cases diagnosed from 1986 to 2016 affecting patients aged 19-years and younger from a tertiary referral center in Brazil. Demographic variables, anatomical site of primary tumors, histopathological diagnoses, signs and symptoms, and patterns of misdiagnosis were collected and interpreted by statistical and descriptive analysis. Results A total of 253 PHNC cases were included. The mean age was 9.3 years and male patients were more frequently affected (60.9%). Burkitt lymphoma (23.7%), nasopharyngeal carcinoma (15.8%), and rhabdomyosarcoma (15.4%) were the most common cancer types. The nasopharynx (28.9%), cervical/lymph node region (25.3%), and craniofacial bones (8.3%) were the predominant anatomical sites. Tumor/swelling (68.4%), was the clinical finding often presented. The univariable analysis showed association between tumor histology and clinical variables such as sex ( p =0.022), age ( p <0.0001), anatomical location ( p <0.0001) tumor/swelling ( p =0.034), pain ( p =0.031), systemic/general manifestations ( p =0.004), nasal/breathing alterations ( p =0.012), orbital/ocular alterations ( p <0.0001). Misdiagnosis such as tonsillitis, otitis, and abscess were frequent. Conclusions Although the clinical findings of PHNC are often unspecific, this study provided signs and symptoms with significant correlations between tumor histology. The suspicion of malignancy should be considered when the main signs and symptoms reported here appear and persist, in order to conduct a timely diagnosis. Key words: Head and neck, cancer, children, adolescent, signs, symptoms.

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“…Furthermore, the characteristic floating tooth/teeth pattern usually described in cases of Burkitt lymphoma were also found in other lymphoma subtypes. 25,26 This feature however was still most commonly seen in BL. Another noteworthy finding was the presence of bone involvement in cases of plasmablastic lymphoma, as recently described by Nel et al 27 who showed a predilection for the posterior region of the maxilla.…”

Section: Discussionmentioning

confidence: 99%

Radiological aspects of lymphomas and leukaemias affecting the jaws: A systematic review

Gomes

Lima

Morais-Perdigão

et al. 2023

J Oral Pathology Medicine

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Background: This systematic review aimed to investigate the radiological features of lymphomas and leukaemias affecting the jaws.Methods: A systematic literature review was conducted using the electronic databases of PubMed, Web of Science and Scopus. Articles that contained sufficient radiographic examinations (periapical, panoramic or computed tomography images) for individual cases were included. Additionally, either immunohistochemical or molecular confirmation was required prior to inclusion. Three authors evaluated and described the image quality and radiological features.Results: From an initial 1079 articles screened, 129 cases were included, containing 88 tomographic, 76 panoramic and 26 periapical examinations. The quality of the majority of images was sufficient for evaluation. Diffuse large B-cell lymphoma, Burkitt lymphoma, leukemic infiltration, plasmablastic lymphoma and extranodal Natural killer (NK)/T-cell lymphoma, nasal type were the most common subtypes. Involved teeth presented with mobility in 37.2% of the cases and a provisional diagnosis of inflammatory/infectious dental disease was considered in 49.2% of cases. Computed tomography exams were available for 76% of the cases, with most presented with an osteolytic lesion with ill-defined borders. Periosteal reactions were uncommon. Conclusion:Lymphoma/leukaemia infiltrates of the jaw bones are usually of highgrade subtypes and rarely present with periosteal reactions.

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Burkitt lymphoma of the head and neck: An international collaborative study

Cited by 13 publications

References 16 publications

Oral and para-oral lymphomas: a 10-year multi-center retrospective study in Egypt with time series analysis and forecasting to 2030

Oral and para-oral lymphomas: a 10-year multi-center retrospective study in Egypt with time series analysis and forecasting to 2030

Clinical manifestations of head and neck cancer in pediatric patients, an analysis of 253 cases in a single Brazilian center

Radiological aspects of lymphomas and leukaemias affecting the jaws: A systematic review

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