Burkitt lymphoma with unusual presentation: Acute pancreatitis

Koca, Tuğba; Aslan, Nagehan; Dereci, Selim; Akçam, Mustafa

doi:10.1111/ped.12640

Cited by 10 publications

(12 citation statements)

References 9 publications

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“…The literature also reported that BL can rarely involve the pancreas. [ 19 , 20 ] In addition, bone marrow involvement is encountered in under 10% of the cases at onset, but is more frequent in case of recurrence or with treatment resistance. [ 21 ] Of our 3 cases diagnosed with BL none presented bone marrow involvement, either the one with IV-stage BL, but in exchange that patient presented central nervous system metastasis.…”

Section: Discussionmentioning

confidence: 99%

Non-Hodgkin lymphoma, diagnostic, and prognostic particularities in children – a series of case reports and a review of the literature (CARE compliant)

Mărginean

Meliţ²,

Horváth³

et al. 2018

Medicine

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Rationale:Non-Hodgkin lymphoma remains an unpredictable condition in pediatric patients.Patient concerns:Our first case describes an 8-year-old boy with a history of iron deficiency anemia, admitted in our clinic for recurrent abdominal pain, weight loss, loss of appetite, diarrheic stools, and fever. The second case also describes an 8-year-old boy admitted for abdominal pain and vomiting. The 3rd case refers to a 4 years and 10 months old boy admitted in our clinic with abdominal pain and loss of appetite, who was initially admitted in the Pediatrics Surgery Clinic with the suspicion of appendicitis. Our 4th patient was a 5-year-old boy admitted in our clinic for abdominal pain and intermittent diarrheic stools.Diagnoses:In the first case, the laboratory tests showed anemia, thrombocytosis, elevated inflammatory biomarkers, a low level of iron, and hypoproteinemia. The abdominal ultrasound and CT exam revealed an abdominal mass, and the histopathological exam established the diagnosis of diffuse large B-cell lymphoma of the bowel. In the second case, the laboratory tests pointed out anemia, elevated ESR and lactate dehydrogenase level, while both abdominal ultrasound and CT exams showed an abdominal mass. The histopathological exam confirmed the diagnosis of Burkitt lymphoma. Regarding our 3rd case, the laboratory findings revealed leukocytosis, anemia, thrombocytosis, increased inflammatory biomarkers, elevated LDH, and a low level of iron. The abdominal ultrasound and the CT scan revealed an abdominal mass which, according to the histopathological exam, was a Burkitt lymphoma. Due to the cranial CT findings the patient was diagnosed with IV stage Burkitt lymphoma with central nervous system metastases. In our 4th patients we found leukocytosis, anemia, mildly increased inflammatory biomarkers, a high level of LDH, hypoproteinemia, and a low level of serum Ir. Both ultrasound and abdominal CT exams were negative, but the exploratory laparotomy identified an abdominal mass, and according to the histopathological exam the patient was diagnosed with Burkitt lymphoma.Interventions:All the patients followed chemotherapy (B-NHL BFM 04 protocol) and supportive treatment.Outcomes:The first patient died approximately 4 months after the completion of chemotherapy due to tumor relapse, the second patient died after the first cure of chemotherapy and the fourth patient died at approximately 2 years after the diagnosis. The third patient is recurrence-free after 2 years.Lessons:Despite the advances in the management, NHL remains a fatal condition in pediatrics.

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Section: Discussionmentioning

confidence: 99%

Non-Hodgkin lymphoma, diagnostic, and prognostic particularities in children – a series of case reports and a review of the literature (CARE compliant)

Mărginean

Meliţ²,

Horváth³

et al. 2018

Medicine

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“…Primary Burkitt's lymphoma of the pancreas is extremely rare with only a few cases described in the literature; some of these cases describe a single mass lesion, whereas other cases describe diffuse pancreatic involvement . Primary pancreatic lymphoma has been described to cause bile and pancreatic duct dilatation and mimic acute cholestatic hepatitis, to present as acute pancreatitis, and also to induce temporary diabetes mellitus …”

Section: Discussionmentioning

confidence: 99%

“…1 Primary Burkitt's lymphoma of the pancreas is extremely rare with only a few cases described in the literature; some of these cases describe a single mass lesion, whereas other cases describe diffuse pancreatic involvement. [2][3][4][5] Primary pancreatic lymphoma has been BIFOCAL PANCREATIC BURKITT'S LYMPHOMA VOL. 45, NO.…”

Section: Discussionmentioning

confidence: 99%

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Bifocal primary pancreatic Burkitt's lymphoma in a 4‐year‐old child

Shapira

Fisher

Ilivitzki

2016

J of Clinical Ultrasound

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“…Primary pancreatic lymphoma represents less than 0.5% of all pancreatic masses in adults. Moreover, acute pancreatitis is a very rare initial presentation of non-Hodgkin lymphomas [5][6][7][8][9][10]. We present the case of a six-year-old girl diagnosed with Burkitt lymphoma who presented with obstructive jaundice and pancreatitis.…”

Section: Introductionmentioning

confidence: 99%

Pediatric pancreatic Burkitt lymphoma with obstructive jaundice: case report of a six-year-old child

Athmani¹,

Rouzic²,

Valduga³

et al. 2017

Arch Clin Cases

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Introduction: Burkitt lymphoma represents about 50% of non-Hodgkin lymphomas and 3% of cancers in children. It commonly affects the abdomen; however, pancreatitis is a very rare initial presentation. Less than 10 cases with this presentation are reported in the literature. Observation: We report the case of a six-year-old girl who presented a rapidly progressing obstructive jaundice evolving for a week. The LDH rate was not increased. Medical imaging has shown a global increase in the size of the pancreas, homogeneous hepatomegaly with dilatation of the gallbladder and the intra-hepatic bile ducts, and infiltration of the left ovary, without ascites. The patient was diagnosed with pancreatic Burkitt Lymphoma after an endoscopic exploration and tumor biopsy. Conclusion: While extremely rare, Burkitt lymphoma should be evoked in the case of pancreatitis with a global increase of the pancreas size, associated with other intra-abdominal organ infiltration in the pediatric population.

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Burkitt lymphoma with unusual presentation: Acute pancreatitis

Cited by 10 publications

References 9 publications

Non-Hodgkin lymphoma, diagnostic, and prognostic particularities in children – a series of case reports and a review of the literature (CARE compliant)

Non-Hodgkin lymphoma, diagnostic, and prognostic particularities in children – a series of case reports and a review of the literature (CARE compliant)

Bifocal primary pancreatic Burkitt's lymphoma in a 4‐year‐old child

Pediatric pancreatic Burkitt lymphoma with obstructive jaundice: case report of a six-year-old child

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