Burn injury mortality in patients with preexisting and new onset renal disease

Knowlin, Laquanda; Purcell, Laura N.; Cairns, Bruce A.; Charles, Anthony

doi:10.1016/j.amjsurg.2018.02.027

Cited by 15 publications

(7 citation statements)

References 18 publications

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“…26 Several studies show the effect of comorbidities, such as renal insufficiency, respiratory diseases, and diabetes mellitus, on the increased risk of hospitalacquired infections and mortality. [27][28][29] The relative protection of older children and young adults is likely explained by an absence of the factors previously discussed for young children while also avoiding the comorbidities of older age. Older children and young adults have the advantage of having more developed immune systems, predictable responses to resuscitation, and robust compensatory mechanisms during stress.…”

Section: Discussionmentioning

confidence: 99%

Re-evaluation of the Effect of Age on In-hospital Burn Mortality in a Resource-Limited Setting

Gallaher

Purcell

Banda

et al. 2021

Journal of Surgical Research

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Background: This global burden of burn injury is suffered disproportionately by people in low-income and middle-income countries, where 70% of all burns occur. Models based in high-income countries to prognosticate burn mortality treat age as a linearly increasing risk factor. It is unclear whether this relationship is similar in resource-limited settings. Methods: We analyzed patients from the Kamuzu Central Hospital Burn Registry in Lilongwe, Malawi, from 2011 to 2019. We examined the relationship between burnassociated mortality and age using adjusted survival analysis over 60 d, categorized into four groups: (1) younger children <5 y; (2) older children 5-17 y; (3) adults 18-40 y; and (4) older adults >40 y. Results: A total of 2499 patients were included. Most patients were <5 y old (n ¼ 1444) with only 133 patients >40 y. Older adults had the highest crude mortality at 34.6% and older children with the lowest at 13%. Compared to younger children, the hazard ratio adjusted for sex, percent total body surface area, and operative intervention was 0.59 (95% confidence interval, 0.44, 0.79) for older children and 0.55 (95% confidence interval, 0.40, 0.76) for adults. Older adults were statistically similar to younger children. Conclusions: We show in this cohort study of burn-injured patients in a resource-limited environment that the relationship between mortality and age is not linear and that the use of age-categorized mortality prediction models is more accurate in delineating mortality characteristics. Categorizing age based on local burn epidemiology will help describe burn mortality characteristics more accurately, leading to better-informed management strategies aimed at attenuating burn mortality for different populations.

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Section: Discussionmentioning

confidence: 99%

Re-evaluation of the Effect of Age on In-hospital Burn Mortality in a Resource-Limited Setting

Gallaher

Purcell

Banda

et al. 2021

Journal of Surgical Research

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“…There is a consensus that increased knowledge about the pathophysiology of burns and advances in their treatment including renal replacement therapy and nutritional support, especially in intensive care units, can help reduce burn-related mortality (Brandão et al, 2021; Knowlin et al, 2018; Nitzschke et al, 2017). Improvements in preventing and controlling and infection in patients with burn injuries have largely contributed to a decline in burn mortality (Al-Shaqsi et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Retrospective Evaluation of Characteristics of Patients with Burn Injuries Treated at the Largest Reference Hospital in Brazil

Carvalho¹,

Paggiaro²,

Nicolosi³

et al. 2023

Plastic and Aesthetic Nursing

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Burn injuries are a significant cause of morbidity and mortality in the Brazilian population. We conducted this study in a tertiary hospital in Brazil to discover the epidemiological characteristics of patients with burn injuries. We conducted a cohort review of patients admitted to the burn unit of our institute during a 5-year period. For each patient, we collected data that included age, gender, total percentage of burned body surface area, burn location, burn mode, and burn cause. We analyzed the data using the R programming language. We included a total of 496 patients in our study. The mean age of the patients was 28 ± 14.7 years. The median length of hospital stay was 2 weeks. We found a significant correlation between the total percentage of burned body surface area and the length of hospitalization (p < .001) and the length of hospitalization in the intensive care unit (p < .001). A total of 427 patients (86%) were discharged from the hospital after successful treatment. In contrast, 43 patients (8.67%) died. The mortality rate was highest in patients who had more than 70% of their total body surface area burned. The average length of hospitalization aligned with global and national statistics presented in the literature. The main causes of the burn injuries were thermal (e.g., fire, hot liquids). We found inhalation injuries present in more than one third of the patients who were hospitalized in the intensive care unit with thermal burns.

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“…Групою міжнародної ініціативи з якості гострого діалізу (ADQI) були розроблені критерії гострого пошкодження нирок Acute Kidney Injury Network (AKIN), які розпізнають раннє пошкодження нирок в умовах інтенсивної терапії. AKIN включають змінення креатиніну та діурезу залежно від часу [22].…”

Section: категоріяunclassified

Скрининг И Диагностика Сепсиса При Тяжелых Ожогах

Sorokina¹,

Koval²

2021

ЕМ

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Зацікавленість проблемою діагностики й інтенсивної терапії сепсису і септичного шоку визначається з 2016 року та зберігається високою на даний час [1]. Згідно з третім міжнародним консенсусом «Сепсис-3», присвяченим визначенню понять «сепсис» та «септичний шок», сепсисом вважають загрозливу для життя органну дисфункцію, що викликана порушен-ням регуляції реакції організму пацієнта на інфекцію [2]. До клінічних критеріїв сепсису відносять підозрювану або документовану інфекцію та виявлені більше двох критеріїв за шкалою SOFA, що обумовлює підвищення госпітальної летальності більш ніж на 10 %. За даними N. Heming et al. (2016), дуже виражена гетерогенність пацієнтів, які страждають від сепсису [3]. У версії 2016 року до Міжнародної класифікації

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Burn injury mortality in patients with preexisting and new onset renal disease

Cited by 15 publications

References 18 publications

Re-evaluation of the Effect of Age on In-hospital Burn Mortality in a Resource-Limited Setting

Re-evaluation of the Effect of Age on In-hospital Burn Mortality in a Resource-Limited Setting

Retrospective Evaluation of Characteristics of Patients with Burn Injuries Treated at the Largest Reference Hospital in Brazil

Скрининг И Диагностика Сепсиса При Тяжелых Ожогах

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