Nursing is a profession that entails a high risk of burnout, so effective organizational management is needed to reduce its occurrence. This study aims to investigate the moderating effects of Nurse Manager caring behaviors and work environment in burnout syndrome among nurses. This study design uses exploratory descriptions with a cross-sectional approach and considers a sample of 485 nurses in the medical surgical wards at three general hospitals in East Java Province, Indonesia. Data collection was performed using three separate questionnaires: The Maslach Burnout Inventory-Human Service Survey (MBI-HSS) to identify burnout syndrome among nurses, Caring Assessment Tool: Administration (CAT: Admn) to identify caring behaviors in nurse managers, and My Relationship with Work test (MRW) to identify work environments. The data was analyzed using Partial Least Square analysis. Nurse manager caring behaviors have a direct effect on personal accomplishment among nurses. The caring behaviors of nurse managers influence control, workload, community, fairness, reward and value. Caring behaviors from nurse managers also affect emotional exhaustion and depersonalization through the mediation of rewards, controls and workload.