Burns in a suicide attempt related to psychiatric side effects of interferon

Fukunishi, Kunimoto; Tanaka, Hiroyuki; Maruyama, Jéssica Mayumi; Takahashi, Hiroshi; Kitagishi, Hideki; Ueshima, T.; Maruyama, Katsuya; Sakata, Ikuhiro

doi:10.1016/s0305-4179(98)00073-4

Cited by 37 publications

(16 citation statements)

References 8 publications

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“…The most common consequence of administering cytokines is the triggering of symptoms of depression (1)(2)(3)(4). In addition, other serious mental complications are the occurrence of suicidal ideation, suicidal attempts, and completion (5)(6)(7)(8). Case reports worldwide have documented death by suicide in patients receiving cytokines as immune boosting therapy to treat a variety of diseases including melanoma, hepatitis C, HIV infections, and multiple sclerosis (5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, other serious mental complications are the occurrence of suicidal ideation, suicidal attempts, and completion (5)(6)(7)(8). Case reports worldwide have documented death by suicide in patients receiving cytokines as immune boosting therapy to treat a variety of diseases including melanoma, hepatitis C, HIV infections, and multiple sclerosis (5)(6)(7)(8)(9). While there is a growing recognition of the participation of cytokines in the etiology of mood disorders, their role as pro-suicidal factors has been less studied (10,11).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Elevated cytokine expression in the orbitofrontal cortex of victims of suicide

Tonelli

Stiller

Rujescu

et al. 2007

Acta Psychiatr Scand

227

145

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Objective-Based on the reported association between cytokines with depression and suicide, and evidence of increased markers of inflammation in the brain of suicide victims, the present study examined the expression of cytokines in the orbitofrontal cortex of suicide victims.Method-In a postmortem sample obtained from the Brodman area 11 of suicides (n = 34) and controls (n = 17), real-time RT-PCR was used to compare the expression of mRNA species for tumor necrosis factor-a (TNF-α), interleukin (IL)-1β, 4, 5, 6, and 13.Results-Increased expression of IL-4 was found in women suicide victims and IL-13 in men suicide victims. Elevated but not significant cytokine expression was also observed for TNF-α in women suicide victims. • Limited information on psychiatric diagnoses and blood toxicology in the suicide group. Conclusion-To NIH Public Access

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elevated cytokine expression in the orbitofrontal cortex of victims of suicide

Tonelli

Stiller

Rujescu

et al. 2007

Acta Psychiatr Scand

227

145

View full text Add to dashboard Cite

show abstract

“…Suicide attempt and completed suicide have been reported with IFN alfa and beta (1,(13)(14)(15). A metaanalysis has indicated a frequency of 7% depressive symptoms during the first six months of treatment with IFN alfa 3 × 10 6 U in patients with CHC.…”

Section: Mood-related Symptomsmentioning

confidence: 99%

Neuropsychiatric Complications of Interferons: Classification, Neurochemical Bases, and Management

Malek-Ahmadi¹,

Hilsabeck²

2007

Annals of Clinical Psychiatry

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“…All of these can compromise the therapeutic response to the treatment. In some cases depression can be so severe that patients experience suicidal ideation, and some published case-reports describe patients who have committed suicide (Ademmer et al, 2001, Dieperink et al, 2004, Fattovich et al, 1996, Fukunishi et al, 1998, Janssen et al, 1994. Effective and timely detection of depression is therefore important to ensure that appropriate treatment and support can be provided.…”

Section: Introductionmentioning

confidence: 99%