Burns

Nielson, Colton; Duethman, Nicholas C.; Howard, James M.; Moncure, Michael; Wood, John G.

doi:10.1097/bcr.0000000000000355

Cited by 246 publications

(68 citation statements)

References 91 publications

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“…Burn injuries and the various types of damage to the organs and systems of the body to which it leads is one of the pressing problems of modern medicine throughout the world and in Ukraine, in particular (Fuzaylov et al, 2015;Gamelli et al, 2015). Burn illness is a symptom complex when there are functional and morphological changes in vital organs and systems, violation of metabolic and neurohumoral processses, burn shock (BS) (Snell et al, 2013;Nielson et al, 2017). The development of pulmonary complications contributes to an increase in mortality of up to 50%, which raises the issue of early diagnosis and prevention of lung injuries in burn shock as an important problem of combustiology (Cox et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Influence of solution of lactoprotein with sorbitol on ultrastructural changes in lungs of rats in the condition of burn shock

Ocheretnyuk

Palamarchuk

Lysenko

et al. 2018

Regul. Mech. Biosyst.

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This article gives a theoretical substantiation and a new experimental solution of a scientific problem aimed at increasing the effectiveness of pharmacotherapy on the morphofunctional state of the lungs of rats under conditions of burn shock by using a combined colloid-hyperosmolar infusion solution – lacto-protein with sorbitol. The administration of the test solution at a dose of 10 ml/kg for 7 days in rats with modelled burn shock reduced ultrastructural changes in the lungs triggered by burn shock. It has been proved that in the conditions of shock, colloid-hyperosmolar infusion lacto-protein with sorbitol solution facilitates the restoration of vascular endothelium and fluid retention in the microcirculatory channel and improves the morphofunctional state of the aerohematic barrier of the lungs, stimulates the activity of the alveolar macrophages and the secretory function of the type II alveolocytes producing surfactant. At day 7 of burn shock, when 0.9% of NaCl was injected, significant changes were observed in the respiratory unit: part of the alveoli had considerably enhanced clearance of blood capillaries, which had platelets, neutrophils and altered forms of erythrocytes. At day 7 of burn shock in the lungs of the rats given an infusion of colloid-hyperosmolar solution – lactoprotein with sorbitol, the ultrastructure of the components of the lung cells had improved in comparison with 3 days. Luminosity of the hemocapillary parts was moderate, mainly with erythrocytes. The walls of endothelial cells had elongated nuclei with invaginations of nuclear membranes and clear contours. Their cytoplasmic regions were not widespread, with moderate electron densities. In type II alveolocytes, during this experiment, a lower degree of damage to the nucleus and organelles in the cytoplasm was established, and there were signs of a renewal of the secretory function of these cells. In the cytoplasm, hypertrophied mitochondria with clear crystals, different sizes of secretory granules, which had a different density, indicating their formation, were observed. According to the magnitude of the cytoprotective effect on lung cells under conditions of burn shock, the lactoprotein with sorbitol solution was shown to be superior in comparison with the physical solution (0.9% NaCl). The study of functional, biochemical and molecular genetic parameters that characterize the state of the aerohematic barrier under the conditions of using lactoprotein with sorbitol solution in the case of burn injuries of the skin will allow researchers to comprehensively evaluate the mechanisms of the pulmonary protective effect of this preparation and to experimentally substantiate the expediency of its use in clinical practice for pharmaco-correction of burn shock.

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Section: Introductionmentioning

confidence: 99%

Influence of solution of lactoprotein with sorbitol on ultrastructural changes in lungs of rats in the condition of burn shock

Ocheretnyuk

Palamarchuk

Lysenko

et al. 2018

Regul. Mech. Biosyst.

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“…Propranolol used in approximately 80% of study patients, reduces oxygen demand and the endogenous catecholamine induced inflammatory response [4], [18]. In the current study, propranolol was only administered after initial definitive burn wound excision with the understanding that propranolol induced peripheral vasoconstriction would be detrimental to the burns wound outcome, extending the zone of stasis according to Jackson’s model [19].…”

Section: Discussionmentioning

confidence: 99%

A ’metabolic bundle‘ including Oxandrolone in optimising the metabolic status of severely burn injured patients: a retrospective analysis of the first 50 patients

Taha

Steinke

Fischer

et al. 2019

GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW; 8:Doc17

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“…Burn wounds evolve in depth and size in the first few days after injury, leading to loss of the integrity of the skin. [3] Burn patient may experience a number of complications such as shock, infection, electrolyte imbalance and respiratory failure [4] . The first step for burn therapy is to promote healing as early as possible.…”

Section: Introductionmentioning

confidence: 99%

Histological and Immunohistochemical Studies on the Role of Stem Cells on the Burned Skin of Adult Male Albino Rats

Allah

Moustafa

Moahmmed

et al. 2020

International Journal of Medical Arts

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Background: Mesenchymal stem cells have delivered new approaches to the management of burn healing in severe skin injuries. Aim of the work: To evaluate the effect of bone marrow-derived mesenchymal stem cells [BMSCs] on healing of induced deep 2nd degree skin burns in albino rats. Methodology: 55 male albino rats weighed 200gm were divided into 5 groups, 5 animals in group I [control] and group II [burn model], 15 animals in group III [untreated], group IV and group V [MSCs treated]. Groups III, IV and V were subdivided into 3 subgroups that were sacrificed after 7, 14 and 21 days respectively. Deep 2nd degree burn wounds were induced on a 4 cm2 area on the back of rats in groups II, III, IV and V by brass probes stabilized at 88-90°C and contacted to the shaved dorsal skin of rats for 20 seconds without exerting any external pressure. Mesenchymal stem cells were isolated from the bone marrow of 5 young rats, weighed 100gm then intra-dermally and intraperitoneally injected. Results: By the end of the third week, the wounds of BMSCs-treated groups showed full regeneration of epidermis, reorganization of collagen and decrease in VEGF immunopositive cells. Delayed wound healing was seen in 20% of systemically treated rats. Significant increase in the mean area percent of collagen fibers was detected in topically treated group. Conclusion: Both methods of BMSCs injection were effective in healing of full thickness skin wound but topical method was more effective.

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Burns

Cited by 246 publications

References 91 publications

Influence of solution of lactoprotein with sorbitol on ultrastructural changes in lungs of rats in the condition of burn shock

Influence of solution of lactoprotein with sorbitol on ultrastructural changes in lungs of rats in the condition of burn shock

A ’metabolic bundle‘ including Oxandrolone in optimising the metabolic status of severely burn injured patients: a retrospective analysis of the first 50 patients

Histological and Immunohistochemical Studies on the Role of Stem Cells on the Burned Skin of Adult Male Albino Rats

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