Buschke–Löwenstein tumor: Three pediatric cases

Aydoğdu, İbrahim; Uzun, Ersan; Mirapoğlu, Semih Lütfi; Kilincaslan, Huseyin; Yıldız, Pelin

doi:10.1111/ped.12960

Cited by 6 publications

(5 citation statements)

References 8 publications

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“…The patient often delays any medical evaluation or initially declines therapy for B-L because of embarrassment, socioeconomic difficulties, or a reluctance to undergo what is feared by the patient to be an extensive surgery, possibly with a penectomy or colostomy. The lesions are also reported in the pediatric literature with patients as young as 2 years, presenting with either vulvar or perianal lesions 11,12 . The literature demonstrates a male predominance, yet some of this disparity likely represents publication bias coupled with the fact that the first reports were of penile lesions.…”

Section: Resultsmentioning

confidence: 98%

“…The lesions are also reported in the pediatric literature with patients as young as 2 years, presenting with either vulvar or perianal lesions. 11,12 The literature demonstrates a male predominance, yet some of this disparity likely represents publication bias coupled with the fact that the first reports were of penile lesions.…”

Section: Clinical Presentation and Evaluationmentioning

confidence: 99%

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Buschke-Lowenstein Tumors: A Review and Proposed Classification System

Davis¹,

Barton²,

Orangio³

et al. 2021

Sexual Trans Dis

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Buschke-Lowenstein (B-L) tumors or giant condylomata are large fungating lesions that are caused by human papillomavirus (HPV) and develop in the anogenital region. Although uncommon, physicians and surgeons who treat sexually transmitted diseases or other diseases involving the anogenital area will encounter these patients. The purpose of this study is to review the current literature regarding these lesions. We evaluated every published study in PubMed and Embase from 1925 to 2020, concentrating on the clinical data included in each report, such as presentation and treatment. We also evaluated each work for any definition used and found that there is no accepted definition for these lesions. As such, we provide an inclusive, workable definition. In addition, there are many misconceptions about B-L that continue to be propogated as more case reports are published every year. After evaluating every published case, we refute the fact that these lesions have a high mortality or a high malignancy rate. Furthermore, we refute that these lesions are synonymous with verrucous carcinoma. In addition to a definition, we also propose a simple grading system that we hope can be used to assist in the study and management of these patients moving forward. Although the literature is very heterogenous regarding B-L, they are caused by HPV and are distinct from verrucous carcinoma. Because of the majority of information is based on case reports, the literature concentrates on treatment, but more work is clearly needed to delineate the association with specific HPV types and optimal management of this disease.

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Section: Resultsmentioning

confidence: 98%

Section: Clinical Presentation and Evaluationmentioning

confidence: 99%

Buschke-Lowenstein Tumors: A Review and Proposed Classification System

Davis¹,

Barton²,

Orangio³

et al. 2021

Sexual Trans Dis

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“…Valdés informó el caso de una niña de 10 años sin antecedente que explicara la transmisión (7) . Ambriz y col indican que, en la edad pe-diátrica, se debe considerar la posible transmisión por abuso sexual (8) . Y Aydogdu informa que se estima que 50 % de los casos en niños son por abuso; sin embargo, publica 3 casos pediátricos sin evidencia de abuso (8) .…”

Section: Presentación Del Casounclassified

“…En las niñas, la transmisión vertical del VPH se presenta en alrededor del 20 % de los casos, que incluye la transmisión periparto, no existiendo una relación con la edad. Esto se muestra en el caso de Perez-Elizondo y col, que informan sobre una niña de 3 años con antecedente de abuso sexual repetido (6)(7)(8)(9) .…”

Section: Presentación Del Casounclassified

Tumor de Buschke-Löwenstein en una niña. A propósito de un caso

Álvarez¹,

Paredes²,

Cabrera³

et al. 2021

Rev peru ginecol obstet.

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El tumor de Buschke-Löwenstein es un condiloma acuminado gigante, benigno, cuyas lesiones clínicas son mayores de 10 cm, por lo que el tratamiento de elección debería ser siempre quirúrgico. Se presenta el caso de una niña de un año con condiloma gigante en la vulva, tumor de Buschke-Löwenstein de rápida evolución, a quien se le practicó resección quirúrgica satisfactoria. Se revisó la literatura respecto a su diagnóstico y tratamiento.

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“…It is usually associated with low-risk human papillomavirus infection, types 6 or 11, and rarely with high-risk types. 1 The significant risk factors include immuno-compromised conditions such as human immunodeficiency virus infection, poor hygiene and sexual or perinatal transmission. 2 About 0•1% of the general population is affected, often adults in their forties, with a male-to-female ratio of 2•7:1.…”

Section: Introductionmentioning

confidence: 99%

A rare case of Buschke–Lowenstein tumour of vulva treated with radical radiotherapy

et al. 2022

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Introduction: Buschke–Lowenstein tumour (BLT) is a rare verrucous lesion often associated with human papillomavirus infection. It is an indolent but locally aggressive lesion usually arising from the genitalia or anorectum, with a potential risk of recurrence and malignant transformation. The first line of management is surgical or laser excision. Topical agents cryotherapy, radiotherapy and chemo-immunomodulators are reserved for residual or recurrent cases and smaller lesions. Methods: A 24-year-old female on antiretroviral therapy presented in our department with a large cauliflower-shaped growth involving the perineum, vulva and lower vagina. A biopsy of the lesion was suggestive of a BLT. Due to the extensive nature of the disease, surgery was deferred. The lesion was treated with definitive external beam radiation therapy (EBRT) using a 6-megavoltage photon beam on a Cobalt-60 unit. Results: Radiotherapy resulted in a significant response without any acute toxicity, following which, topical podophyllin application was advised for the residual perianal lesion. The patient is disease free after 9 months of follow-up. Conclusions: A multidisciplinary approach is important to treat the BLT. Lesions not amenable to surgery or local therapies can be treated with EBRT with reasonable control and acceptable toxicities.

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Buschke–Löwenstein tumor: Three pediatric cases

Cited by 6 publications

References 8 publications

Buschke-Lowenstein Tumors: A Review and Proposed Classification System

Buschke-Lowenstein Tumors: A Review and Proposed Classification System

Tumor de Buschke-Löwenstein en una niña. A propósito de un caso

A rare case of Buschke–Lowenstein tumour of vulva treated with radical radiotherapy

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